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    LAMA2, PLXDC2 AND MLL4 AS NOVEL BIOMARKERS FOR PREDIABETES AND DIABETES
    521.
    发明申请
    LAMA2, PLXDC2 AND MLL4 AS NOVEL BIOMARKERS FOR PREDIABETES AND DIABETES 有权

    公开(公告)号：US20220206014A1

    公开(公告)日：2022-06-30

    申请号：US17611155

    申请日：2020-05-12

    Applicant: ACADEMIA SINICA

    Inventor： Wen-Chin YANG ,  Meng-Ting YANG

    IPC: G01N33/68 ,  G01N33/543

    Abstract: The invention relates to LAMA2, PLXDC2 and MLL4 as novel biomarkers for prediabetes and diabetes. Specifically, use of a set of probes with specific binding affinities to prediabetes and diabetes protein markers comprising MLL4, LAMA2 and PLXDC2 for screening prediabetes and diabetes for care and/or treatment is disclosed. The set of probes comprises a first probe, a second probe and a third probe having specific binding affinities to the MLL4, LAMA2, and PLXDC2, respectively. A diagnostic kit device/apparatus comprising a set of probes is disclosed. A method for detecting and identifying prediabetes and/or diabetes in a subject in need thereof is also disclosed. The subject in need thereof identified as having prediabetes or diabetes is subject to a care and/or a treatment regime for the prediabetes or diabetes. Also disclosed is a method for identifying prediabetes and/or diabetes protein markers.

    BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA
    523.
    发明申请
    BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA 有权

    公开(公告)号：US20220174986A1

    公开(公告)日：2022-06-09

    申请号：US17598284

    申请日：2020-03-22

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG ,  Yu-Chuar LIANG

    IPC: A23K10/30 ,  A23K50/30 ,  A61K36/28

    Abstract: A composition comprising Bidens pilosa or an active compound isolated from the Bidens pilosa for use in treating, inhibiting and/or decreasing the presence of pathogenic gut microbiota in an animal in need thereof is disclosed. The pathogenic gut microbiota are at least one selected from the group consisting of Brachyspira, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis coronavirus (TGEV) and Rotavirus (RV). The composition is also for use in treating, inhibiting and/or decreasing occurrence of swine diarrhea, swine dysentery, swine viral infection and increasing the percentage of swine carcass and bone weight. In one embodiment, the composition is for use in treating, inhibiting and/or decreasing occurrence of swine dysentery associated with Brachyspira.

    LIPOSOMES AND USES THEREOF
    524.
    发明申请
    LIPOSOMES AND USES THEREOF 有权

    公开(公告)号：US20220151926A1

    公开(公告)日：2022-05-19

    申请号：US17586807

    申请日：2022-01-28

    Applicant: Academia Sinica

    Inventor： Hsien-Ming LEE ,  Hua-De GAO ,  Jia-Lin HONG ,  Chih-Yu KUO ,  Cheng-Bang JIAN

    IPC: A61K9/127 ,  A61K47/65 ,  A61K47/69

    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

    Compounds and methods for treating osteoarthritis
    525.
    发明授权
    Compounds and methods for treating osteoarthritis 有权

    公开(公告)号：US11332490B1

    公开(公告)日：2022-05-17

    申请号：US17182156

    申请日：2021-02-22

    Applicant: Academia Sinica

    Inventor： Shang-Cheng Hung ,  Chi-Huey Wong ,  Ting-Jen Cheng

    IPC: C07H7/02

    Abstract: Disclosed herein are substrates and/or inhibitors of endo-O-sulfatase 1 (Sulf-1). According to some embodiments, the substrates and/or inhibitors of Sulf-1 are compounds of formula (I) or (II), In formula (I) or (II), n is 2 or 3; X is methylene, O, or N; R1 is —SO3M, or —SO2NH2; R2 is C1-6 alkyl or C1-6 alkylamine; and M is a monovalent cation selected from the group consisting of lithium, sodium, potassium, and ammonium. Also encompasses herein are methods of identifying and treating a subject having or suspected of having osteoarthritis. The method includes steps of (a) mixing a urine sample of the subject with 4-methylumbelliferyl sulfate (4-MUS) and a Sulf-1 inhibitor of formula (I) or (II); (b) determining a fluorescence intensity of the mixture of the step (a); and (c) treating the subject with an analgesic, a non-steroidal anti-inflammatory drug (NSAID), or a corticosteroid when the determined fluorescence intensity of the step (b) is smaller than that of a control sample, which is a mixture of the urine sample and 4-MUS.

    Biosensor, bio-sensing system comprising the same and method for preparing the same
    528.
    发明申请
    Biosensor, bio-sensing system comprising the same and method for preparing the same 有权

    公开(公告)号：US20220099673A1

    公开(公告)日：2022-03-31

    申请号：US17485815

    申请日：2021-09-27

    Applicant: Academia Sinica

    Inventor： Chia-Fu CHOU ,  Stalin KARUPPIAH

    IPC: G01N33/569 ,  G01N27/327

    Abstract: A biosensor is provided, which comprises: a substrate; a working electrode disposed on the substrate and comprising a graphene layer; a counter electrode disposed on the substrate and adjacent to the working electrode; a reference electrode disposed on the substrate and adjacent to the working electrode; and a bio-recognition layer disposed on the working electrode. In addition, a bio-sensing system comprising the aforesaid biosensor and a method for preparing the aforesaid biosensor are also provided.

    Methods for modifying human antibodies by glycan engineering
    529.
    发明授权
    Methods for modifying human antibodies by glycan engineering 有权

    公开(公告)号：US11267870B2

    公开(公告)日：2022-03-08

    申请号：US16150190

    申请日：2018-10-02

    Applicant: Academia Sinica

    Inventor： Chi-Huey Wong ,  Chung-Yi Wu

    IPC: C07K16/00 ,  C12P21/00

    Abstract: Modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.

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