公开(公告)号：US08513402B2

公开(公告)日：2013-08-20

申请号：US13245180

申请日：2011-09-26

Applicant: Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

Inventor： Kwangmeyung Kim ,  Ick Chan Kwon ,  Kuiwon Choi ,  In Chan Youn ,  MyungSook Huh ,  Sojin Lee

IPC: C07H21/04

CPC classification number: C12N15/111 ,  A61K47/643 ,  C12N2320/32

Abstract: Disclosed are a human serum albumin-siRNA carrier system having siRNA bound to human serum albumin and a user thereof, and especially, human serum albumin-siRNA carrier system, which has a biodegradable covalent bond between human serum albumin polymer and siRNA and is stable in a living body, and a user thereof.The human serum albumin-siRNA carrier system having the biodegradable covalent bond between the human serum albumin and the siRNA exhibits high siRNA delivery efficiency to a target site in the living body. Therefore, the human serum albumin-siRNA carrier system may allow siRNA for therapy to be efficiently delivered to a target site such as cancer tissues in the living body even by being administrated in a relatively low concentration, which may result in a wide use for therapies of various diseases.

Abstract translation: 公开了具有与人血清白蛋白结合的siRNA及其使用者的人血清白蛋白-siRNA载体体系，特别是人血清白蛋白-siRNA载体体系，其在人血清白蛋白聚合物和siRNA之间具有可生物降解的共价键，并且在 生物体及其使用者。 在人体血清白蛋白和siRNA之间具有可生物降解的共价键的人血清白蛋白-siRNA载体体系对生物体中的靶位点显示出高的siRNA递送效率。 因此，人体血清白蛋白-siRNA载体体系可以使siRNA用于治疗有效地递送到目标部位如生物体中的癌组织，甚至通过以相对低的浓度施用，这可能导致广泛用于治疗 的各种疾病。

公开(公告)号：US20130209352A1

公开(公告)日：2013-08-15

申请号：US13756569

申请日：2013-02-01

Applicant: Jong Soo JURNG ,  Eun Seuk PARK ,  Sung Min CHIN ,  Min Su KIM

Inventor： Jong Soo JURNG ,  Eun Seuk PARK ,  Sung Min CHIN ,  Min Su KIM

IPC: B01J12/02

CPC classification number: B01J12/02 ,  B01J4/008 ,  B01J19/243 ,  B01J2219/00094 ,  B01J2219/00135 ,  B82Y40/00 ,  Y10S977/773 ,  Y10S977/896

Abstract: Disclosed are an apparatus and a method for manufacturing composite nanoparticles. The apparatus comprises: a first precursor supply unit vaporizing a first precursor and supplying it to a reaction unit; a second precursor supply unit vaporizing a second precursor and supplying it to the reaction unit; the reaction unit producing composite nanoparticles by reacting the vaporized first precursor with the vaporized second precursor; an oxygen supply line supplying an oxygen source to the reaction unit; and a collection unit collecting the composite nanoparticles produced by the reaction unit. Since gas phase synthesis occurs in different stages using the U-shaped reaction chamber, aggregation is prevented and composite nanoparticles of uniform size and high specific surface area can be produced easily.

Abstract translation: 公开了一种制造复合纳米颗粒的装置和方法。 该装置包括：第一前体供应单元蒸发第一前体并将其供应到反应单元; 第二前体供应单元蒸发第二前体并将其供应到反应单元; 所述反应单元通过使汽化的第一前体与汽化的第二前体反应来生产复合纳米颗粒; 向所述反应单元供给氧源的供氧线; 以及收集由反应单元生成的复合纳米颗粒的收集单元。 由于使用U形反应室在不同的阶段发生气相合成，因此可以防止聚集，容易产生尺寸均匀，比表面积高的复合纳米颗粒。

公开(公告)号：US20130199976A1

公开(公告)日：2013-08-08

申请号：US13687262

申请日：2012-11-28

Applicant: Korea Institute of Science and Technology

Inventor： Seong Pil JEONG ,  Seockheon LEE

IPC: C02F1/44

CPC classification number: C02F1/447 ,  B01D61/364 ,  B01D2313/22 ,  B01D2315/06 ,  B82Y99/00

Abstract: A membrane distillation module is provided. The membrane distillation module includes a feed water side, a membrane, and a treated water side. A heating element is mounted in the feed water side. The membrane distillation module may optionally further include a heat spreading element. The heat spreading element is mounted in contact with the heating element to improve the efficiency of heat diffusion to the membrane.

Abstract translation: 提供了膜蒸馏模块。 膜蒸馏模块包括给水侧，膜和处理水侧。 加热元件安装在给水侧。 膜蒸馏模块可以任选地进一步包括散热元件。 散热元件安装成与加热元件接触，以提高对膜的热扩散效率。

公开(公告)号：US20130199612A1

公开(公告)日：2013-08-08

申请号：US13677733

申请日：2012-11-15

Applicant: Korea Institute of Science and Technology

Inventor： Ho Won JANG ,  Seok Jin YOON ,  Deok Ha WOO ,  Jin Sang KIM ,  Hyo Jin KWON ,  Chong Yun KANG ,  Ji Won CHOI

IPC: H01L31/0232

CPC classification number: H01L31/02327 ,  B82Y30/00 ,  C03C17/42 ,  C03C2217/425 ,  C03C2217/73 ,  C03C2217/76 ,  H01L31/02168 ,  H01L31/02366 ,  H02S40/10 ,  Y02E10/50 ,  Y10S977/755 ,  Y10T428/24355

Abstract: Provided are a hydrophobic antireflective substrate, a method for manufacturing the same, and a solar cell module including the same. The hydrophobic antireflective substrate includes: a substrate; a nanostructured layer having nanostructured portions formed on the substrate and nanoporous portions formed between the nanostructured portions; and a hydrophobic coating film formed on the nanostructured portions. The method for manufacturing a hydrophobic antireflective substrate includes: forming a nanostructured layer having nanostructured portions and nanoporous portions formed between the nanostructured portions on a substrate; and forming a hydrophobic coating film on the nanostructured portions. In the hydrophobic antireflective substrate disclosed herein, a porous nanostructured layer is formed on the substrate and a hydrophobic coating film is formed on the nanostructured layer, so that the hydrophobic antireflective substrate has ultra-hydrophobic property corresponding to a large water droplet contact angle.

Abstract translation: 提供了一种疏水性抗反射基板，其制造方法以及包括该防反射基板的太阳能电池模块。 疏水性抗反射基板包括：基板; 具有形成在所述基板上的纳米结构部分和形成在所述纳米结构部分之间的纳米多孔部分的纳米结构层; 以及形成在纳米结构部分上的疏水涂膜。 制造疏水性抗反射基板的方法包括：在基板上形成具有纳米结构部分和形成在纳米结构部分之间的纳米多孔部分的纳米结构层; 并在纳米结构部分上形成疏水性涂膜。 在本文公开的疏水性抗反射基板中，在基板上形成多孔纳米结构化层，在纳米结构层上形成疏水性涂膜，疏水性防反射基板具有对应于大的水滴接触角的超疏水性。

公开(公告)号：US08492384B2

公开(公告)日：2013-07-23

申请号：US12492615

申请日：2009-06-26

Applicant: Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

Inventor： Kyung Il Choi ,  Ghilsoo Nam ,  Hye Ran Kim ,  Hyewhon Rhim ,  Seon Hee Seo ,  Yoon Jee Kim ,  Hee Sup Shin ,  Dong Jin Kim ,  Ae Nim Pae ,  Hye Jin Chung ,  Yong Seo Cho ,  Hyunah Choo ,  Eun Joo Roh ,  Soon Bang Kang ,  Kye Jung Shin ,  Hoh Gyu Hahn ,  Dong Yun Shin ,  Chan Seong Cheong ,  Kee Dal Nam ,  Yong Koo Kang ,  Jae Kyun Lee ,  Woong Seo Park ,  Youngsoo Kim ,  Eunice Eun-Kyeong Kim ,  Key-Sun Kim ,  Hesson Chung ,  Gyo Chang Keum ,  Cheolju Lee ,  Kee Hyun Choi

IPC: A61K31/496 ,  C07D233/64

CPC classification number: C07D233/60 ,  C07D209/48 ,  C07D233/54 ,  C07D233/61 ,  C07D403/06

Abstract: Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Abstract translation: 公开了可用作钙通道调节剂的新型咪唑烷基羰基衍生物及其制备方法。 还公开了通过基于其对钙通道的抑制活性施用上述化合物来治疗疾病的方法。

公开(公告)号：US20130178436A1

公开(公告)日：2013-07-11

申请号：US13737482

申请日：2013-01-09

Applicant: Korea Institute of Science and Technology

Inventor： Ki Sung Kang ,  Su-Nam Kim, I ,  Jungyeob Ham ,  Woojung Lee ,  Noriko Yamabe ,  Ji Hwan Lee

IPC: A61K31/704

CPC classification number: A61K31/704 ,  A23L33/105 ,  A61K9/0095 ,  A61K9/1623 ,  A61K9/1664 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866

Abstract: A composition for preventing, improving, or treating renal diseases, the composition including as an active ingredient a Maillard browning reaction product obtained by reacting ginsenoside Re, an extract of Panax species plant including ginsenoside Re, or glucose with amino acid at a temperature of 100 to 130° C. for 0.5 to 12 hours.

Abstract translation: 用于预防，改善或治疗肾脏疾病的组合物，所述组合物包含作为活性成分的美拉德褐变反应产物，其通过使人参皂甙Re，人参皂甙Re的人参提取物或葡萄糖与氨基酸在100℃的温度下反应而获得 至130℃，保持0.5至12小时。

公开(公告)号：US20130156063A1

公开(公告)日：2013-06-20

申请号：US13812290

申请日：2010-07-27

Applicant: Keehoon Kim

Inventor： Keehoon Kim

IPC: G01N25/20

CPC classification number: G01N25/20 ,  G01N25/18

Abstract: The present invention relates to a material screening apparatus, and more particularly, to a material screening apparatus that senses temperature change according to the thermal characteristics of the material to be screened so as to extract a thermal characteristic value for the material and determine the type of the material. The material screening apparatus according to an embodiment of the present invention comprises: a plurality of heat generators for variably generating heat; a plurality of temperature sensors attached to the heat generators, respectively, for measuring the changing temperatures of the heat generators; and a controller for controlling the heat generation by the heat generators, performing the calculations of the temperature values measured by the plurality of temperature sensors, and outputting the thermal characteristic value of the material.

Abstract translation: 本发明涉及一种材料筛选装置，更具体地说，涉及一种材料筛选装置，其根据被筛选材料的热特性来检测温度变化，从而提取材料的热特性值，并确定 材料。 根据本发明的实施例的材料筛选装置包括：多个用于可变地产生热量的发热体; 分别连接到发热体的多个温度传感器，用于测量发热体的变化温度; 以及控制器，用于控制热发生器的发热，执行由多个温度传感器测量的温度值的计算，并输出该材料的热特性值。

公开(公告)号：US20130143904A1

公开(公告)日：2013-06-06

申请号：US13623948

申请日：2012-09-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOL

Inventor： Changjoon Justin LEE ,  Sang-Soo KANG ,  Kyung-Suk HAN ,  Eun-Joo ROH ,  Jae-Yong PARK ,  Bo Mi KU ,  Yeon Kyung LEE ,  Antoine G. ALMONTE ,  Dongho WOO ,  Jung-Hwan PARK ,  Seon Ha PAEK

IPC: A61K31/522

CPC classification number: A61K31/522

Abstract: An agent for inhibiting the activity of inositol-1,4,5-triphospate receptor subtype 3 (IP3R3), containing caffeine and/or its analogs, and/or their pharmaceutically acceptable salts, as an active ingredient, is provided. A composition for preventing and/or treating a disease associated with Ca2+ release through IP3R3, containing the IP3R3 inhibiting agent, is also provided.

Abstract translation: 提供了用于抑制含有咖啡因和/或其类似物的肌醇-1,4,5-三磷酸受体亚型3（IP3R3）和/或其药学上可接受的盐作为活性成分的活性的药剂。 还提供了用于预防和/或治疗与包含IP3R3抑制剂的IP3R3释放相关的疾病的组合物。

公开(公告)号：US20130130063A1

公开(公告)日：2013-05-23

申请号：US13678856

申请日：2012-11-16

Applicant: Korea Institute of Science and Technology

Inventor： Gyung Min CHOI ,  Byoung Chul MIN ,  Kyung Ho SHIN

IPC: G11B5/64 ,  G11B5/66 ,  G11B5/84 ,  G11B5/72

CPC classification number: G11B5/645 ,  G11B5/65 ,  G11B5/66 ,  G11B5/72 ,  G11B5/84 ,  H01F10/123 ,  H01F10/3254 ,  H01F10/3286 ,  H01F41/32 ,  H01L43/10 ,  H01L43/12

Abstract: A perpendicularly magnetized thin film structure and a method of manufacturing the perpendicularly magnetized thin film structure are provided. The perpendicularly magnetized thin film structure includes i) a base layer, ii) a magnetic layer located on the base layer and having an L10-crystalline structure, and iii) a metal oxide layer located on the magnetic layer.

Abstract translation: 提供垂直磁化的薄膜结构和制造垂直磁化的薄膜结构的方法。 垂直磁化的薄膜结构包括：i）基底层，ii）位于基底层上并具有L10结晶结构的磁性层，和iii）位于磁性层上的金属氧化物层。

公开(公告)号：US20130101635A1

公开(公告)日：2013-04-25

申请号：US13650670

申请日：2012-10-12

Applicant: Kwideok PARK ,  Soon Eon BAE ,  Dong Keun HAN

Inventor： Kwideok PARK ,  Soon Eon BAE ,  Dong Keun HAN

IPC: C12N5/00 ,  A61K35/32 ,  A61K35/28

CPC classification number: C12N5/0062 ,  A61K35/28 ,  A61K35/32 ,  C12N2533/90

Abstract: Methods of preparing a self-assembled matrix from cell-derived extracellular matrice, and of inducing cell proliferation and differentiation by using the self-assembled matrix, and applying the self-assembled matrix into cell therapy. In detail, unique extracellular matrices obtained from particular cells are collected and then subjected to decellularization in order to form a self-assembled matrix including nano fibers only formed of extracellular matrix. In addition, the matrix prepared as described above provides a platform that is effective for the induction of the mass proliferation or differentiation of cells, and thus, may be applied in manufacturing cell therapy products.

Abstract translation: 从细胞衍生的细胞外基质制备自组装基质的方法，以及通过使用自组装基质诱导细胞增殖和分化，以及将自组装基质应用于细胞治疗。 详细地，从特定细胞获得的独特的细胞外基质被收集，然后进行脱细胞化以形成仅由细胞外基质形成的纳米纤维的自组装基质。 此外，如上所述制备的基质提供了对诱导细胞的大量增殖或分化有效的平台，因此可以应用于制造细胞治疗产品。