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公开(公告)号:US20200339584A1
公开(公告)日:2020-10-29
申请号:US16764873
申请日:2018-11-16
Applicant: Academia Sinica
Inventor: Te-Chang LEE , Tsann-Long SU , Tai-Lin CHEN
IPC: C07D487/04 , A61P35/02
Abstract: Disclosed herein are novel bifunctional compounds and their uses for the treatment and/or prophylaxis of cancers. The bifunctional compound disclosed herein has the structure of formula (I).
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公开(公告)号:US10804431B2
公开(公告)日:2020-10-13
申请号:US16243645
申请日:2019-01-09
Applicant: ACADEMIA SINICA
Inventor: Yun-Chorng Chang
Abstract: Current-injecting nanorod LEDs are demonstrated to emit linear polarized light that is detected from the backside of the sample. The polarization ratio of the electroluminescence reaches 71% when the length of the minor axis is as small as 150 nm. Electromagnetic simulation confirms the occurrence of the polarization selectivity especially when the length of the minor axis is down to 150 nm. The destructive interference between the light directly from light source and the reflected light by the top metal interface is the origin of the selectivity. Emission with the polarization perpendicular to the nanorods is extracted out of the nanorods and the remaining light with the other polarization transmits to the substrate. The linearly polarized light can be also detected from the front side of the sample if the conductive pad is transparent. The simulation also suggests that it is possible to obtain circularly or elliptically polarized light by tuning the height of the nanorods. These observed phenomena could also apply to fin-shaped nanowall LED. The results in this study will be beneficial for applications that required linearly or circularly polarized light especially for devices that are not suitable to use an external polarizer.
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公开(公告)号:US10752673B2
公开(公告)日:2020-08-25
申请号:US15619835
申请日:2017-06-12
Applicant: Academia Sinica
Inventor: An-Suei Yang , Hong-Sen Chen , Chung-Ming Yu , Shin-Chen Hou , Wei-Ying Kuo , Yi-Kai Chiu , Yueh-Liang Tsou , Hung-Ju Hsu , Hwei-Jiung Wang , Shih-Hsien Chuang , Chao-Pin Lee
Abstract: Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method combines a phage-displayed synthetic antibody library and high-throughput cytotoxicity screening of non-covalently assembled immunotoxins or cytotoxic drug to identify highly functional synthetic antibody fragments for delivering toxin payloads.
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564.
公开(公告)号:US10752657B2
公开(公告)日:2020-08-25
申请号:US16258115
申请日:2019-01-25
Applicant: Academia Sinica
Inventor: Chiaho Shih , Heng-Li Chen , Pei-Yi Su
IPC: C07K14/005 , A61K39/12 , A61K39/29 , C12N7/00 , A61K38/00
Abstract: A pharmaceutical composition comprising: (a) an isolated peptide, wherein the peptide includes three or four arginine-rich domains (ARDs) from the carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an anti-microbial activity; and (b) a pharmaceutically acceptable carrier.
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公开(公告)号:US20200161110A1
公开(公告)日:2020-05-21
申请号:US16686203
申请日:2019-11-17
Applicant: Academia Sinica
Inventor: Abdil OZDEMIR , Jung-Lee LIN , Chung-Hsuan CHEN
Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.
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公开(公告)号:US10584341B2
公开(公告)日:2020-03-10
申请号:US15755958
申请日:2016-08-31
Applicant: Academia Sinica , National Taiwan University
Inventor: Pan-Chyr Yang , Wei-Yun Lai , Bo-Tsang Huang
IPC: C12N15/11 , C12N15/115 , A61K31/711 , A61P35/00
Abstract: Aptamers that bind to and antagonize PDL1 and uses thereof in enhancing immune activity (e.g., promoting T cell proliferation), treating cancer, and/or infectious diseases such as infections caused by enterovirus, HBV, or HCV infection.
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567.
公开(公告)号:US10584120B1
公开(公告)日:2020-03-10
申请号:US16552554
申请日:2019-08-27
Applicant: National Health Research Institutes , Academia Sinica
Inventor: Chih-Hao Chen , Chuan Shih , Chiung-Tong Chen , Hwei-Jiung Wang , Kai-Fa Huang
IPC: C07D417/14 , C07D403/14 , C07D413/14 , A61P25/28 , C07D409/14 , A61K45/06
Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.
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公开(公告)号:US10568897B2
公开(公告)日:2020-02-25
申请号:US15589963
申请日:2017-05-08
Applicant: ACADEMIA SINICA
Inventor: Wen-Chin Yang , Lee-Tian Chang
IPC: A61K36/00 , A61K31/7028 , A23K20/163 , A23K20/10 , A23K50/75 , A61K36/28 , A23K10/30 , A23K50/70 , A23K20/00 , A23K50/80 , A23K20/195
Abstract: A composition for use in prevention, inhibition and/or treatment of coccidiosis in an animal is disclosed. The composition comprises an effective amount of Bidens pilosa, an active constituent thereof, or an active compound isolated therefrom. In another aspect, a composition for use in enhancing growth in an animal is disclosed. The composition comprising an animal feed and an effective amount of Bidens pilosa, or an isolated active constituent comprising a polyacetylenic compound.
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公开(公告)号:US10533179B2
公开(公告)日:2020-01-14
申请号:US15500345
申请日:2015-07-31
Applicant: Academia Sinica , National Taiwan University , Taipei Medical University
Inventor: Konan Peck , Pan-Chyr Yang , Yi-Chung Chang , Bo-Tsang Huang , Shauh-Der Yeh
IPC: C12N15/115 , C12N15/113 , A61K31/711 , A61K9/00 , A61K31/713 , A61K47/60
Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.
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公开(公告)号:US10533034B2
公开(公告)日:2020-01-14
申请号:US15866378
申请日:2018-01-09
Applicant: ACADEMIA SINICA
Inventor: Chi-Huey Wong , Alice L. Yu , Kun-Hsien Lin , Tai-Na Wu
Abstract: Glycosphingolipids (GSLs) compositions and methods for iNKT-independent induction of chemokines are disclosed.
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