公开(公告)号：US10248324B2

公开(公告)日：2019-04-02

申请号：US15329730

申请日：2015-07-31

Applicant: Cornell University

Inventor： Rafael Pass ,  Elette Boyle ,  Kai-Min Chung

IPC: G06F12/00 ,  G06F3/06 ,  G06F13/16 ,  G06F12/084 ,  G06F12/0842 ,  G06F12/1072 ,  G06F13/38

Abstract: A secure parallel processing technique for converting any parallel random access machine (PRAM) into an oblivious parallel random access machine (OPRAM), whose distribution of memory accesses is statistically independent of the data (with negligible error), while only inducing a polylogarithmic slowdown to both the total and parallel complexities of the program.

公开(公告)号：US20190085323A1

公开(公告)日：2019-03-21

申请号：US16202106

申请日：2018-11-28

Applicant: Academia Sinica

Inventor： An-Suei Yang ,  Jhih-Wei Jian ,  Hong-Sen Chen ,  Yi-Kai Chiu ,  Hung-Pin Peng ,  Chao-Ping Tung ,  Chung-Ming Yu ,  Wei-Ying Kuo ,  Hung-Ju Hsu

IPC: C12N15/10 ,  C40B40/02 ,  C07K16/00 ,  C07K16/32 ,  C07K16/28 ,  C07K16/30 ,  C07K16/22

Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in having a specific CS combination and a specific sequence in each CDR. The present scFv library is useful in efficiently producing different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.

公开(公告)号：US10232013B2

公开(公告)日：2019-03-19

申请号：US15403595

申请日：2017-01-11

Applicant: Academia Sinica

Inventor： Jyh-Yih Chen ,  Chen-Hung Ting

IPC: A61K45/06 ,  A61K45/00 ,  A61K38/17 ,  A61K38/00

Abstract: The preset invention relates to a new approach for treating a cancer, particularly a malignant tumor, a multidrug-resistant (MDR) cancer, a recurrent cancer or a metastatic cancer, using a specific cationic antimicrobial peptide (CAP), tilapia piscidin 4 (TP4), which is derived from Nile Tilapia (Oreochromis niloticus). Also provided is a method for treating a breast cancer, particularly triple negative breast cancer (TNBC) with TP4.

公开(公告)号：US10184128B2

公开(公告)日：2019-01-22

申请号：US15210445

申请日：2016-07-14

Applicant: ACADEMIA SINICA

Inventor： Hsou-Min Li ,  Chiung-Chih Chu

IPC: C12N15/82

Abstract: The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kD (prTic40), chaperonin 10-2 (prCpn10-2), Fibrillin 1B (prFibrillin), ATP sulfurylase 1 (prAPS1), ATP sulfurylase 3 (prAPS3), 5′-adenylylsulfate reductase 3 (prAPR3), stromal ascorbate peroxidase (prsAPX), prTic40-E2A (a prTic40 variant), prCpn10-1-ΔC7C37S (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides.

公开(公告)号：US10172919B2

公开(公告)日：2019-01-08

申请号：US15537051

申请日：2015-12-29

Applicant: ACADEMIA SINICA

Inventor： Shie-Liang Hsieh ,  Yung-Chi Chang ,  Ming-Ting Huang

IPC: A61K39/00 ,  A61K38/17 ,  C07K14/705

Abstract: Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.

公开(公告)号：US10119972B2

公开(公告)日：2018-11-06

申请号：US15666242

申请日：2017-08-01

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Jiun-Jie Shie

IPC: C07D311/02 ,  G01N33/58 ,  C07F5/02 ,  C07K7/08 ,  G01N21/64 ,  C07D309/14

Abstract: Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

公开(公告)号：US10118969B2

公开(公告)日：2018-11-06

申请号：US15011544

申请日：2016-01-30

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Che Ma ,  Han-Chung Wu

IPC: C12N9/24 ,  C07K16/30 ,  C07K16/28 ,  A61K45/06 ,  C07K16/10 ,  C07K16/32 ,  C07K16/18 ,  C12P21/00

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

公开(公告)号：US10048264B2

公开(公告)日：2018-08-14

申请号：US14538888

申请日：2014-11-12

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Shui-Tein Chen ,  Chong-Jen Yu ,  Potprommanee Laddawan ,  Haou-Tzong Ma

IPC: G01N33/574 ,  C07K14/47

Abstract: The present invention relates to a lung cancer biomarker for diagnosing early stage lung cancers or predicting prognosis of lung cancers, which comprises a GM2AP protein. The present invention also relates to a method for diagnosing early stage lung cancers or predicting prognosis of lung cancers in vitro by detection of the biomarker.

公开(公告)号：US10005746B2

公开(公告)日：2018-06-26

申请号：US14504681

申请日：2014-10-02

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Sunney Ignatius Chan ,  Sheng-Fa Yu ,  Penumaka Nagababu ,  Suman Maji ,  Ping-Yu Chen ,  Ravirala Ramu ,  Chung-Yuan Mou ,  Chih-Cheng Liu

IPC: C07C29/48 ,  C07C45/28 ,  B01J31/22 ,  C07D301/02 ,  C07C49/04 ,  C07C49/303 ,  C07F1/08

CPC classification number: C07D301/02 ,  B01J31/2243 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/0216 ,  B01J2531/0241 ,  B01J2531/16 ,  C07C29/48 ,  C07C45/28 ,  C07C49/04 ,  C07C49/303 ,  C07C2601/14 ,  C07C2601/16 ,  C07F1/08 ,  Y02P20/52 ,  C07C31/04 ,  C07C31/08 ,  C07C31/10 ,  C07C31/12 ,  C07C31/125 ,  C07C35/08 ,  C07C31/207

Abstract: This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to molecular catalysts for efficient catalytic oxidation of hydrocarbons, such as hydrocarbons from natural gas. The molecular catalytic platform provided herein is capable of the facile oxidation of hydrocarbons, for example, under ambient conditions such as near room temperature and atmospheric pressure.

公开(公告)号：US09985230B2

公开(公告)日：2018-05-29

申请号：US14824580

申请日：2015-08-12

Applicant: ACADEMIA SINICA

Inventor： Kuei-Hsien Chen ,  Hsieh-Cheng Han ,  Ching-Chun Chang ,  Li-Chyong Chen ,  Chan-Yi Du

IPC: H01L51/50 ,  H01L51/42 ,  H01L51/44 ,  H01L51/00

CPC classification number: H01L51/424 ,  H01L51/0036 ,  H01L51/0043 ,  H01L51/0046 ,  H01L51/0047 ,  H01L51/005 ,  H01L51/0055 ,  H01L51/4246 ,  H01L51/44 ,  Y02E10/549

Abstract: The present invention is related to a process for reducing surface energy of a hole transport layer. The disclosed process comprises providing a hole transport layer; and providing a fluorine-containing layer directly on said hole transport layer. The configuration of said fluorine-containing layer reduces the structural disorder of an active layer and is able to recover a moisture-degraded hole transport layer, and thereby improves the performance of an electric device containing the same.