-
公开(公告)号：US20240026311A1
公开(公告)日：2024-01-25
申请号：US17769655
申请日：2020-10-16
发明人： Shinichi HOSHINO , Nao HOSODA
CPC分类号： C12N9/0008 , C12Y102/01012 , C12N9/0006 , C12Y101/01027 , C07K14/4717 , C07K14/47
摘要： Provided is a technique for improving the translation efficiency of mRNA. The mRNA includes: a 5′ untranslated region of an mRNA encoding a protein; and a 3′ untranslated region having 40% or more and 80% or less complementarity to the 5′ untranslated region.
-
公开(公告)号：US11725189B2
公开(公告)日：2023-08-15
申请号：US16544993
申请日：2019-08-20
发明人： Takahiro Iwao , Tamihide Matsunaga , Satoshi Kondo , Shota Mizuno
CPC分类号： C12N5/0679 , G01N33/5014 , G01N33/5044 , C12N2501/115 , C12N2501/119 , C12N2501/415 , C12N2501/999 , C12N2506/45
摘要： It is an object to provide a culture method which is capable of maintaining and/or culturing iPS cell-derived intestinal stem cells, while maintaining the properties of intestinal stem cells. The induced pluripotent stem cell-derived intestinal stem cell-like cells are cultured in the presence of a GSK-3β inhibitor, a histone deacetylation inhibitor, and a serum replacement, or in the presence of a GSK-3β inhibitor and a serum replacement. Preferably, the culture is carried out under conditions in which one or more compounds selected from the group consisting of an epidermal growth factor, a TGFβ receptor inhibitor and a fibroblast growth factor are further present.
-
公开(公告)号：US20230192890A1
公开(公告)日：2023-06-22
申请号：US17933229
申请日：2022-09-19
申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY , PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , PHARMA FOODS INTERNATIONAL CO., LTD.
发明人： Mamoru SATO , Michiyuki YAMADA , Satoshi KANAZAWA , Masayoshi TOYOURA , Yuji SHOYA , Kenji SAITO , Chihiro YAMAZAKI
IPC分类号： C07K16/40 , C12N9/99 , C12N15/09 , A61K39/395 , C12N15/63
CPC分类号： C07K16/40 , C12N9/99 , C12N15/09 , A61K39/395 , A61K39/3955 , C12N15/63 , C12Y305/03015 , C07K2317/33 , C07K2317/622 , A61K2039/505
摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0×10−9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.
-
公开(公告)号：US20230057230A1
公开(公告)日：2023-02-23
申请号：US17789867
申请日：2021-01-07
IPC分类号： G01N33/574
摘要： The present invention provides a novel method for detecting an indicator of T cell lymphoma. The method for detecting an indicator of T cell lymphoma includes the step of detecting acetylated tubulin in a T cell that has been collected from a subject.
-
公开(公告)号：US20230052551A1
公开(公告)日：2023-02-16
申请号：US17616784
申请日：2020-06-08
发明人： Yasuteru URANO , Toru KOMATSU , Shingo SAKAMOTO , Hiroyuki NOJI , Hidehiko NAKAGAWA , Mitsuyasu KAWAGUCHI , Rikiya WATANABE
摘要： Provided is a novel fluorescent probe.
A compound of the following general formula (I) or a salt thereof.-
56.发明授权公开(公告)号：US11499963B2
公开(公告)日：2022-11-15
申请号：US16083226
申请日：2017-03-03
发明人： Takahiro Iwao , Tomoki Kabeya , Tamihide Matsunaga
摘要： An object of the present invention is to provide a novel method which enables convenient preparation of cells exhibiting functions close to that of intestinal epithelial cells of living bodies, and use of the method. The differentiation of induced pluripotent stem cells into intestinal epithelial cells is induced by step of differentiating induced pluripotent stem cells into endoderm-like cells; step of differentiating the endoderm-like cells obtained in step into intestinal stem cell-like cells; and step of differentiating the intestinal stem cell-like cells obtained in step into intestinal epithelial cell-like cells, wherein step includes culture in the presence of a MEK1 inhibitor, a DNA methyltransferase inhibitor, a TGF-β receptor inhibitor, and EGF and under the condition that cAMP is supplied to the cells.
-
公开(公告)号：US20220213613A1
公开(公告)日：2022-07-07
申请号：US17703294
申请日：2022-03-24
发明人： Junpei YAMANAKA , Akiko Toyotama , Tohru Okuzono , Minori Fujita , Yurina Aoyama , Madoka Minami
摘要： A colloidal crystal having a diamond lattice structure, including: a first layer in which a first plurality of particles are arranged to form a plane of a face-centered cubic lattice structure; a second layer in which a second plurality of particles are arranged on the first layer in contact with the first particles; and a third layer in which a third plurality of particles are arranged on the second layer in contact with the second particles, wherein the colloidal crystal includes at least one layer of each of the first layer, the second layer and the third layer.
-
公开(公告)号：US20210269884A1
公开(公告)日：2021-09-02
申请号：US17253571
申请日：2019-05-28
发明人： Takaya SHIMURA , Hiroyasu IWASAKI
IPC分类号： C12Q1/6886 , C12Q1/689
摘要： An object is to provide a highly practical, gastric cancer-specific, and minimally invasive biomarker. As gastric cancer biomarkers, hsa-miR-6807-5p, hsa-miR-6856-5p and hsa-miR-575 have been identified. The morbidity of gastric cancer is determined using expression levels of the microRNAs as an index.
-
公开(公告)号：US20210093883A1
公开(公告)日：2021-04-01
申请号：US17050766
申请日：2019-04-05
发明人： Jun MORI , Katsuji IGUCHI , Hitoshi AOKI , Akimichi MORITA , Hideyuki MASUDA , Makoto KIMURA
IPC分类号： A61N5/06
摘要： An object is to uniformly irradiate a non-flat affected area with light. Provided is an irradiation apparatus (1) configured to irradiate a projecting part of a body of an irradiation target organism with light, the irradiation apparatus including: a cover (2); a light source unit (3); and a sheet (4) that is provided so that the light source unit (3) does not make contact with an affected area of the projecting part or an area surrounding the affected area, the sheet (4) and/or the cover (2) being configured to make contact with the area surrounding the affected area.
-
公开(公告)号：US10907216B2
公开(公告)日：2021-02-02
申请号：US16097954
申请日：2017-03-31
发明人： Yasuhito Tanaka , Kentaro Matsuura
摘要： The present invention addresses the problem of how to provide a predictive marker useful for carcinogenesis surveillance after hepatitis C virus eradication. Provided is a predictive marker composed of a single nucleotide polymorphism specified by rs17047200. In the present invention, the single nucleotide polymorphism is detected in nucleic acid samples collected from subjects, thereby to examine the risk of developing hepatocellular carcinoma after of hepatitis C virus eradication.
-
-
-
-
-
-
-
-
-
搜索结果
73 条记录 (耗时 0.024 秒)
