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    Benzenesulfonamide compounds and the use thereof
    51.
    发明授权
    Benzenesulfonamide compounds and the use thereof 有权
    苯磺酰胺化合物及其用途

    公开(公告)号：US08937181B2

    公开(公告)日：2015-01-20

    申请号：US12296788

    申请日：2007-04-13

    Applicant: Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

    Inventor： Akira Matsumura ,  Hidenori Mikamiyama ,  Bin Shao ,  Naoki Tsuno ,  Jiangchao Yao

    IPC: C07D211/58 ,  A61K31/4545 ,  A61K31/4468

    CPC classification number: C07D211/58 ,  A61K31/4468 ,  A61K31/4545

    Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

    Abstract translation: 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1-R3，Z，p和q如说明书所述定义。 本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。 本发明的化合物特别适用于治疗疼痛。

    Proline analogs as ligands for cannabinoid receptors
    53.
    发明授权
    Proline analogs as ligands for cannabinoid receptors 有权
    脯氨酸类似物作为大麻素受体的配体

    公开(公告)号：US08084612B2

    公开(公告)日：2011-12-27

    申请号：US12350450

    申请日：2009-01-08

    Applicant: Bin Shao ,  Jiangchao Yao

    Inventor： Bin Shao ,  Jiangchao Yao

    IPC: C07D409/12

    CPC classification number: C07D409/12 ,  C07D207/48 ,  C07D403/12 ,  C07D409/14

    Abstract: The invention relates to compounds of Formulae I(a) to XI and pharmaceutically acceptable salts and solvates thereof (Proline Analog Compounds), that are useful, e.g., as ligands for cannabinoid receptors, as compositions comprising a Proline Analog Compound and a pharmaceutically acceptable carrier, in methods of making such Proline Analog Compounds, and in methods for treating or preventing a Condition, such as pain, nausea, vomiting and an eating disorder, comprising administering an effective amount of a Proline Analog Compound to an animal in need thereof.

    Abstract translation: 本发明涉及式I（a）至XI的化合物及其药学上可接受的盐和溶剂合物（脯氨酸类似物化合物），其可用作例如大麻素受体的配体，作为包含脯氨酸类似物化合物和药学上可接受的载体的组合物 ，在制备这种脯氨酸类似物化合物的方法中，以及用于治疗或预防诸如疼痛，恶心，呕吐和进食障碍的病症的方法中，包括向有需要的动物施用有效量的脯氨酸类似物化合物。

    Aryl substituted pyridines and the use thereof
    54.
    发明授权
    Aryl substituted pyridines and the use thereof 有权
    芳基取代的吡啶及其用途

    公开(公告)号：US07943643B2

    公开(公告)日：2011-05-17

    申请号：US12546572

    申请日：2009-08-24

    Applicant: Bin Shao ,  R. Richard Goehring ,  Samuel F. Victory

    Inventor： Bin Shao ,  R. Richard Goehring ,  Samuel F. Victory

    IPC: A61K31/4418 ,  C07D213/26

    CPC classification number: C07D213/81 ,  C07D213/82 ,  Y10T436/145555

    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    Abstract translation: 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4被置于说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

    Aryl substituted pyridines and the use thereof
    57.
    发明授权
    Aryl substituted pyridines and the use thereof 有权
    芳基取代的吡啶及其用途

    公开(公告)号：US07579367B2

    公开(公告)日：2009-08-25

    申请号：US11518448

    申请日：2006-09-11

    Applicant: Bin Shao ,  R. Richard Goehring ,  Samuel F. Victory

    Inventor： Bin Shao ,  R. Richard Goehring ,  Samuel F. Victory

    IPC: A61K31/4418 ,  C07D213/26

    CPC classification number: C07D213/81 ,  C07D213/82 ,  Y10T436/145555

    Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    Abstract translation: 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4被置于说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

    Process for isolation and purification of xanthophyll crystals from plant oleoresin
    58.
    发明授权
    Process for isolation and purification of xanthophyll crystals from plant oleoresin 失效
    从植物油树脂中分离和纯化叶黄素晶体的方法

    公开(公告)号：US07271298B2

    公开(公告)日：2007-09-18

    申请号：US11336869

    申请日：2006-01-23

    Applicant: Xinde Xu ,  Bin Shao ,  Di Zhou ,  Shuangming Ye ,  Yanfeng Wang ,  Boqiu Chen

    Inventor： Xinde Xu ,  Bin Shao ,  Di Zhou ,  Shuangming Ye ,  Yanfeng Wang ,  Boqiu Chen

    IPC: C07C35/21

    CPC classification number: C07C403/24

    Abstract: A process for isolation and purification of xanthophylls crystals from plant oleoresin is disclosed. The organic solvents involved in the process is no other than food grade alcohol. The process includes saponifying the plant oleoresin containing xanthophyll diesters, neutralizing the saponified reaction mixture with an acid and washing water-soluble impurities and other fat-soluble oil with warm water and alcohol, respectively. The process can improve purity and yield of products, by which the content and the recovery of xanthophylls are as high as 90% and 80% respectively. And the process is economical and easy to perform in industrial production.

    Abstract translation: 公开了从植物油树脂中分离和纯化叶黄素晶体的方法。 涉及该方法的有机溶剂不是食品级酒精。 该方法包括皂化含有叶黄素二酯的植物油树脂，用酸中和皂化反应混合物，并分别用温水和酒精洗涤水溶性杂质和其他脂溶性油。 该方法可以提高产品的纯度和产量，其中叶黄素的含量和回收率分别高达90％和80％。 该工艺在工业生产中经济实惠。

    Benzimidazole compounds having nociceptin receptor affinity
    60.
    发明申请
    Benzimidazole compounds having nociceptin receptor affinity 失效
    具有伤害感受器受体亲和力的苯并咪唑化合物

    公开(公告)号：US20060264638A1

    公开(公告)日：2006-11-23

    申请号：US11494826

    申请日：2006-07-28

    Applicant: Donald Kyle ,  Richard Goehring ,  Bin Shao

    Inventor： Donald Kyle ,  Richard Goehring ,  Bin Shao

    IPC: C07D403/02

    CPC classification number: C07D401/04

    Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.

    Abstract translation: 公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4， >和X 1'如本文所公开的。 该化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。

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