公开(公告)号：US20230110178A1

公开(公告)日：2023-04-13

申请号：US17810316

申请日：2022-06-30

Applicant: JANSSEN BIOTECH, INC.

Inventor： RHYS SALTER ,  VADIM DUDKIN ,  FENGBIN SONG ,  WEI ZHANG ,  SHALOM GOLDBERG ,  JOHN KEITH

IPC: A61K51/02 ,  A61K51/04 ,  A61K51/10

Abstract: Macrocyclic chelators for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.

公开(公告)号：US11618787B2

公开(公告)日：2023-04-04

申请号：US16177239

申请日：2018-10-31

Applicant: Janssen Biotech, Inc.

Inventor： Tahamtan Ahmadi ,  Christopher Chiu ,  Ming Qi ,  Amy Sasser ,  Jordan Schecter

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K31/573 ,  A61K31/495 ,  A61K31/4439 ,  A61K31/69 ,  A61K9/00 ,  A61K31/454 ,  A61K39/00

Abstract: Disclosed are methods of treating a subject having high-risk multiple myeloma, methods of achieving negative minimal residual disease status in a subject having multiple myeloma, and methods of predicting a likelihood of, or decreasing a risk of, relapse and/or disease progression in a subject having multiple myeloma.

公开(公告)号：US20230086884A1

公开(公告)日：2023-03-23

申请号：US17822450

申请日：2022-08-26

Applicant: YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

Inventor： Byoungmoon LEE ,  Hyunjoo LEE ,  Gyu Jin LEE ,  Su Bin CHOI ,  Sol PARK ,  Heejun KIM ,  Misong KIM ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Tae Kyun KIM ,  Jae Young SIM ,  Marian C. BRYAN ,  Scott KUDUK ,  James Campbell ROBERTSON

IPC: C07D401/14

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20230086795A1

公开(公告)日：2023-03-23

申请号：US17822438

申请日：2022-08-26

Applicant: YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

Inventor： Hyunjoo LEE ,  Su Bin CHOI ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Jae Young SIM ,  Marian C. BRYAN ,  Scott KUDUK ,  James Campbell Robertson ,  Jaekyoo LEE ,  Paresh Devidas SALGAONKAR ,  Byung-Chul SUH ,  Jong Sung KOH ,  So Young HWANG

IPC: C07D401/14

Abstract: Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US11603405B2

公开(公告)日：2023-03-14

申请号：US16418082

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Francois Gaudet ,  Jill Giles-Komar ,  Bradley Heidrich ,  Chichi Huang ,  Colleen Kane ,  Ronan McDaid ,  Jennifer Nemeth-Seay

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The present invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.

公开(公告)号：US20230060162A1

公开(公告)日：2023-03-02

申请号：US18054372

申请日：2022-11-10

Applicant: Janssen Biotech, Inc.

Inventor： Yanqing Chen ,  Charles Tang ,  Ernesto J. Munoz-Elias

IPC: G06T7/11

Abstract: An image processing method is provided that automatically calculates Body Surface Area (BSA) score using machine learning techniques. A Felzenszwalb image segmentation algorithm is used to define proposed regions in each of a plurality of training set images. The training set images are oversegmented, and then each of the proposed regions in each of the plurality of oversegmented training set images are manually classified as being a lesion or a non-lesion. A Convolutional Neural Network (CNN) is then trained using the manually classified proposed regions in each of the plurality of training set images. The trained CNN is then used on test images to calculate BSA scores.

公开(公告)号：US20230047413A1

公开(公告)日：2023-02-16

申请号：US17747785

申请日：2022-05-18

Applicant: Janssen Biotech, Inc.

Inventor： Marc Mercken ,  Thomas Malia ,  Marianne Borgers ,  Kristof Van Kolen

IPC: C07K16/18 ,  A61P25/28 ,  G01N33/68 ,  A61K9/00 ,  C07K16/44

Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and use of the antibodies for treating or preventing conditions such as tauopathies.

公开(公告)号：US20230042465A1

公开(公告)日：2023-02-09

申请号：US17860416

申请日：2022-07-08

Applicant: Janssen Biotech, Inc.

Inventor： Ann Donlon ,  Charles Goochee ,  Gary Gordon ,  Ronan Hayes ,  Robin Johnston, JR. ,  Willem Steenvoorden ,  Denis Twomey

IPC: C07K16/24

Abstract: The present invention relates to methods of manufacture for producing anti-TNF antibodies, e.g., the anti-TNF antibody golimumab, and specific pharmaceutical compositions of the antibody.

公开(公告)号：US20230040065A1

公开(公告)日：2023-02-09

申请号：US17860244

申请日：2022-07-08

Applicant: Janssen Biotech, Inc.

Inventor： Kristopher Barnthouse ,  John Brown ,  Brett Hanna ,  Linda Hendricks ,  Manuel Lopez, JR. ,  Mark Panek ,  Denis Twomey ,  David Volkin

IPC: C07K16/24

Abstract: The present invention relates to methods of manufacture for producing a drug substance (DS) or drug product (DP) comprising a mammalian anti-TNF antibody having a heavy chain (HC) comprising SEQ ID NO: 36 and a light chain (LC) comprising SEQ ID NO: 37.

公开(公告)号：US20230037448A1

公开(公告)日：2023-02-09

申请号：US17773098

申请日：2020-10-30

Applicant: Janssen Biotech, Inc.

Inventor： Justin Cisar ,  Colleen Keohane ,  Scott Kuduk

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00 ,  A61P35/02

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.