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公开(公告)号：US20120093924A1
公开(公告)日：2012-04-19
申请号：US13282145
申请日：2011-10-26
Applicant: Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
Inventor： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC: A61K31/232 , A61P3/06 , A61K9/48
CPC classification number: A61K31/232 , A61K31/202 , A61K45/06 , G06F19/00
Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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52.发明申请PHARMACEUTICAL COMPOSITION COMPRISING EICOSAPENTAENOIC ACID AND NICOTINIC ACID AND METHODS OF USING SAME 审中-公开包含苹果酸和非丁酸的药物组合物及其使用方法公开(公告)号：US20110236476A1
公开(公告)日：2011-09-29
申请号：US13061865
申请日：2009-09-02
Applicant: Mehar Manku
Inventor： Mehar Manku
IPC: A61K9/48 , A61K31/455 , A61P9/00 , A61P3/06
CPC classification number: A61K31/202 , A61K31/232 , A61K31/455 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising eicosapentaenoic acid and/or derivatives thereof and nicotinic acid, to methods of manufacturing such compositions, and to therapeutic methods for treating carious diseases and disorders.
Abstract translation: 本发明尤其涉及包含二十碳五烯酸和/或其衍生物和烟酸的药物组合物，涉及制备该组合物的方法，以及治疗龋齿疾病和病症的治疗方法。
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公开(公告)号：US20100311834A1
公开(公告)日：2010-12-09
申请号：US12702889
申请日：2010-02-09
Applicant: Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
Inventor： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC: A61K31/232 , A61P3/06
CPC classification number: A61K31/232 , A61K31/202 , A61K45/06 , G06F19/00
Abstract: In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
Abstract translation: 在各种实施方案中，本发明提供了治疗和/或预防心血管相关疾病，特别是血脂治疗方法的方法，其包括向有需要的受试者施用包含二十碳五烯酸或其衍生物的药物组合物。
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54.再颁专利1,3-Propane diol esters and ethers and methods for their use in drug delivery 失效1,3-丙二醇酯和醚及其用于药物递送的方法公开(公告)号：USRE40480E1
公开(公告)日：2008-09-02
申请号：US11405041
申请日：1996-05-01
Applicant: Sherri Clarkson , Mehar Manku , Philip Knowles , Peter Redden , Andrea Pitt , Paul Bradley , Paul Wakefield , Austin McMordie
Inventor： David B. Horrobin
IPC: C07C57/13
CPC classification number: Y02A50/411
Abstract: The invention relates to compounds of formula: wherein R1 is selected from the group consisting of fatty acid acyl groups of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, and wherein R2 is selected from the group consisting of H, fatty acid acyl of 12 to 30 carbon atoms and fatty alcohol groups of 12 to 30 carbon atoms, the same as or different from R1, and the residue of a nutrient, drug, or other bioactive compound, and to the use of these compounds to deliver drugs and other bioactive compounds.
Abstract translation: 本发明涉及下式的化合物：其中R 1选自12至30个碳原子的脂肪酸酰基和12至30个碳原子的脂肪醇基团，其中R 1， SUP> 2选自H，12-30个碳原子的脂肪酸酰基和12-30个碳原子的脂肪醇基，与R 1相同或不同 >，以及营养物，药物或其他生物活性化合物的残留物，以及这些化合物用于递送药物和其它生物活性化合物的用途。
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公开(公告)号：US07375215B2
公开(公告)日：2008-05-20
申请号：US10221218
申请日：2001-03-08
Applicant: Paul Bradley , Mehar Manku
Inventor： Paul Bradley , Mehar Manku
IPC: C07D487/22 , C07D47/00 , C08G18/08 , A01N55/02 , A61K31/409 , A61K31/555
CPC classification number: C07D487/22 , A61K41/0071
Abstract: A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).
Abstract translation: 通过与二异氰酸酯，二异硫氰酸酯或异氰酸酯 - 异硫氰酸酯在一个异氰酸酯或异硫氰酸酯基团的加成反应，在一个或多个羟基衍生的四（羟基苯基）二氢卟酚，细菌二氢卟酚或异细菌素，其它异氰酸酯或异硫氰酸酯基团本身由 与w-烷基化或酰化的聚（环氧烷）的羟基或本身携带这种聚（环氧烷）的残基的连接残基的羟基的加成反应。
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Patent Agency Ranking
公开(公告)号：US06245811B1
公开(公告)日：2001-06-12
申请号：US09376617
申请日：1999-08-18
Applicant: David Frederick Horrobin , Mehar Manku , Austin McMordie , Philip Knowles , Peter Redden , Andrea Pitt
Inventor： David Frederick Horrobin , Mehar Manku , Austin McMordie , Philip Knowles , Peter Redden , Andrea Pitt
IPC: A61K31225
CPC classification number: C07D213/30 , C07C69/007 , C07C69/587 , C07C69/76 , C07D209/28 , C07D213/66 , C07D233/94 , C07D279/36 , C07D321/00 , C07D339/04 , C07D499/00 , C07F9/091 , C07F9/65522 , C07J1/0059 , C07J5/0053
Abstract: Compounds of structure (I), and when for use in therapy: where R1 is an acyl group derived from a C16-30 fatty acid with two or more cis or trans double bonds and particularly an n-6 or n-3 series EFA or conjugated linoleic acid, or columbinic acid, or parinaric acid and R2 is as R1 the same or different, or any other nutrient, drug or other bioactive residue released as the active in the body and R3 is either hydrogen, fully hydrocarbon, or containing heteroatoms, preferably an alkyl group particularly a C1-C4 alkyl group.
Abstract translation: 结构（I）的化合物和用于治疗的时间：其中R1是衍生自具有两个或多个顺式或反式双键的C16-30脂肪酸的酰基，特别是n-6或n-3系列EFA或 共轭亚油酸或哥伦比酸或仲丁酸，R2为R1相同或不同的任何其它营养物质或作为活性物质释放的其他生物活性残基，R3为氢，完全烃或含杂原子 ，优选烷基，特别是C 1 -C 4烷基。
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公开(公告)号：US5990164A
公开(公告)日：1999-11-23
申请号：US930701
申请日：1998-03-17
Applicant: David F. Horrobin , Philip Knowles , Mehar Manku , John C. Stewart
Inventor： David F. Horrobin , Philip Knowles , Mehar Manku , John C. Stewart
IPC: A23L1/30 , A61K8/00 , A61K8/30 , A61K8/33 , A61K8/36 , A61K8/41 , A61K31/20 , A61K31/202 , A61Q5/02 , C07C57/03 , C07C215/10 , A61K31/215
CPC classification number: C07C57/03 , C07C215/10
Abstract: An N-alkylpolyhydroxyamine salt of an n-6 or n-3 essential fatty acid (EFA) that is beyond the 6-desaturation step, or of any polyunsaturated fatty acid, other than those belonging to the n-6 and n-3 series, having 16 to 26 carbon atoms and up to six double bonds, the double bonds being in the cis or trans configuration, the salt being formed with the fatty acid either as such or in the form of a covalent derivative, through the carboxyl group, of a bifunctional compound itself having a free acid function.
Abstract translation: PCT No.PCT / GB96 / 00952 Sec。 371日期：1998年3月17日 102（e）1998年3月17日PCT 1996年4月19日PCT PCT。 出版物WO96 / 33155 日期1996年10月24日除了6-去饱和步骤以外的n-6或n-3必需脂肪酸（EFA）的N-烷基多羟基胺盐或任何多不饱和脂肪酸，属于n-6 和n-3系，具有16至26个碳原子和多至六个双键，双键呈顺式或反式构型，盐与脂肪酸形成或者以共价衍生物形式， 通过羧基，具有游离酸功能的双官能化合物本身。
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58.发明授权Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy 有权用于降低受试者中伴随的他汀类药物治疗的甘油三酸酯的组合物和方法公开(公告)号：US08710041B2
公开(公告)日：2014-04-29
申请号：US13403699
申请日：2012-02-23
Applicant: Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
Inventor： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
CPC classification number: A61K31/232 , A61K9/48 , A61K31/202 , A61K31/366 , A61K31/40 , A61K31/505 , A61K2300/00
Abstract: In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
Abstract translation: 在各种实施方案中，本发明提供了在有需要的受试者中治疗和/或预防心血管相关疾病的组合物和方法。
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59.发明申请COSMETIC COMPOSITIONS COMPRISING EPA AND GLA AND METHODS OF MAKING AND USING SAME 有权包含EPA和GLA的化妆品组合物及其制备和使用方法公开(公告)号：US20140066509A1
公开(公告)日：2014-03-06
申请号：US14020176
申请日：2013-09-06
Applicant: Mehar Manku , John Climax , David Coughlan
Inventor： Mehar Manku , John Climax , David Coughlan
CPC classification number: A61K47/12 , A61K8/361 , A61K8/368 , A61K31/202 , A61K31/375 , A61K31/60 , A61Q19/00 , A61Q19/004 , A61Q19/08 , A61K2300/00
Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and GLA free acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
Abstract translation: 本公开一般涉及包含EPA游离酸和游离GLA的酸的化妆品组合物。 在一些实施方案中，化妆品组合物具有美容上可接受的气味。
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公开(公告)号：US08501225B2
公开(公告)日：2013-08-06
申请号：US13614146
申请日：2012-09-13
Applicant: Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
Inventor： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC: A61K9/48 , A61K31/232 , A61K31/202 , A61P9/00 , A61P9/10
CPC classification number: A61K31/202 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K31/232 , A61K45/06
Abstract: The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
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