-
51.
公开(公告)号:US20140213611A1
公开(公告)日:2014-07-31
申请号:US14131351
申请日:2012-07-06
IPC分类号: C07D333/38 , C07D215/48 , C07C237/20 , C07D261/18 , C07D207/16 , C07C317/28 , C07D213/81
CPC分类号: C07K5/06078 , A61K38/00 , C07C237/20 , C07C237/22 , C07C317/28 , C07D207/16 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D215/48 , C07D231/14 , C07D233/90 , C07D261/18 , C07D277/30 , C07D277/56 , C07D307/68 , C07D333/24 , C07D333/38 , C07D333/60 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06191
摘要: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R9 are as defined herein.
摘要翻译: 本发明提供式(I)化合物:包含这些化合物的组合物; 这种化合物在治疗中的用途(例如在治疗或预防涉及血浆激肽释放酶活性的疾病或病症中); 以及用这些化合物治疗患者的方法; 其中R 1至R 9如本文所定义。
-
公开(公告)号:US08752770B2
公开(公告)日:2014-06-17
申请号:US12543849
申请日:2009-08-19
IPC分类号: G06K9/00
CPC分类号: G06Q20/3558 , G06Q20/18 , G06Q20/3278 , G06Q20/341 , G06Q20/352 , G06Q20/355 , G06Q20/409 , G07F7/1008 , G07F11/00 , G07F17/0014 , G07F17/42
摘要: Pursuant to some embodiments, methods, apparatus, systems, devices, and means for issuing a payment device from a remote dispensing device are provided which include receiving a request to purchase a payment device from the remote dispensing device, the request including a load amount. Device information is read from a pre-personalized payment device in the remote dispensing device, and a request is made to an issuer of the pre-personalized payment device, for personalization data to personalize the pre-personalized payment device. In some embodiments, the request is sent over a secure authenticated session established between a module of the dispensing device and the issuer. The personalization data is loaded in the pre-personalized payment device to create a personalized payment device, and the personalized payment device is dispensed for use by a consumer.
摘要翻译: 根据一些实施例,提供了用于从远程分配设备发出支付设备的方法,设备,系统,设备和装置,其包括从远程分配设备接收购买支付设备的请求,该请求包括负载量。 从远程分配设备中的预先个性化的支付设备读取设备信息,并且向预先个性化的支付设备的发行者请求个性化数据以个性化预先个性化的支付设备。 在一些实施例中,通过在分配装置的模块和发行者之间建立的安全认证会话来发送请求。 个性化数据被加载在预先个性化的支付设备中以创建个性化支付设备,并且个性化支付设备被分配供消费者使用。
-
公开(公告)号:US08700618B2
公开(公告)日:2014-04-15
申请号:US12464703
申请日:2009-05-12
申请人: Michael Evans , Brian Guarraci , Pete Parsons , Michel Bastien , Matty Noble , Ben Straley
发明人: Michael Evans , Brian Guarraci , Pete Parsons , Michel Bastien , Matty Noble , Ben Straley
CPC分类号: G06F17/30887 , G06Q30/02
摘要: A facility for tracking the sharing of distinguished content is described. When a user seeks to access the distinguished content from a client computer system using a URL associated with the distinguished content, the facility determines whether a user identifier is represented in the URL. If a user identifier is represented in the URL that is different from a user identifier that is persistently stored by the client computer system, the facility determines that the distinguished content has been shared with a user identified by the user identifier that is persistently stored by the client computer system by a user identified by the identifier represented in the URL.
摘要翻译: 描述了用于跟踪区分内容的共享的设施。 当用户尝试使用与识别的内容相关联的URL从客户端计算机系统访问区分内容时,该设施确定用户标识符是否在URL中被表示。 如果用户标识符在URL中被表示为不同于由客户端计算机系统持久存储的用户标识符,则设备确定已识别的内容已经被用户标识符标识的用户共享,该用户标识符被持久存储 客户端计算机系统由用户标识的标识符表示在URL中。
-
54.
公开(公告)号:US08645068B2
公开(公告)日:2014-02-04
申请号:US12921429
申请日:2009-02-27
申请人: Michael Evans , John Rasmus , Richard Radtke
发明人: Michael Evans , John Rasmus , Richard Radtke
IPC分类号: G06F19/00
摘要: A downhole tool and method for determining a parameter of a formation as a function of radial distance from the borehole into the formation. The tool comprising a nuclear source for irradiating the formation and a plurality of sensors each independently measuring a density of the formation at a different radial depth into the formation. A processor combines the density measurements for determining the parameter of the formation as a function of radial distance.
摘要翻译: 一种用于确定地层参数作为从钻孔到地层的径向距离的函数的井下工具和方法。 该工具包括用于照射地层的核源和多个传感器,每个传感器独立地测量地层在不同径向深度处的地层的密度。 处理器将用于确定地层参数的密度测量结合为径向距离的函数。
-
公开(公告)号:US08603396B2
公开(公告)日:2013-12-10
申请号:US13058574
申请日:2008-08-21
CPC分类号: G01N15/1459 , G01N15/1404 , G01N15/147 , G01N2015/1438 , G01N2015/149 , G01N2015/1497 , Y10T436/11
摘要: Particular embodiments of the inventive technology relate to ‘off-axis detector’ technology that employs a third detector 23 exhibiting a flow orthogonal axis 43 as defined by its EMR collection angle, where such axis is from 30 degrees to 60 degrees from an intended, flow orthogonal, cell cross section long axis alignment line 13, in addition to employing a fourth detector 24 exhibiting a flow orthogonal axis 44 as defined by its collection angle, where such axis is orthogonal to the flow orthogonal, third detector axis 43. Particular embodiments of the inventive technology relate to ‘axially spaced illumination’ technology featuring more than one cell illumination site, where, other than the most upflow illumination site (e.g., 121), all illumination site(s) are downflow of at least one other illumination site. Particular embodiments of the inventive technology may feature aspects of both technologies.
摘要翻译: 本发明技术的特定实施例涉及“离轴检测器”技术,其采用表现出由其EMR收集角度定义的流动正交轴43的第三检测器23,其中该轴线与预期的流动相距30度至60度 正交的单元横截面长轴对准线13,除了采用表现出由其收集角度限定的流动正交轴44的第四检测器24,其中该轴与正交正交的第三检测器轴43正交。具体实施方式 本发明技术涉及具有多于一个单元照明位置的“轴向间隔照明”技术,其中除了最上升的照明位置(例如,121)之外,所有照明位置都是至少一个其他照明位置的下流。 本发明技术的特定实施例可以具有两个技术的特征。
-
公开(公告)号:US20130153657A1
公开(公告)日:2013-06-20
申请号:US13331613
申请日:2011-12-20
申请人: Kevin Loughrey , Ivan Curtis , Michael Evans
发明人: Kevin Loughrey , Ivan Curtis , Michael Evans
CPC分类号: G06K19/06037
摘要: Tagging apparatus associated with applying and reading a tag adapted to store a number. The tag comprising a plurality of substantially identical two dimensional arrays of dots, each array being indicative of the number for improving tag detection; each arrays comprise a plurality of clusters, each cluster representing a predetermined symbol being indicative of a part of the number. An etching apparatus, for creating a pattern of dots, comprising a plurality of laser sources held in a manifold defining any one or more of a vector grid, or array grid. A tagging reading apparatus comprising a lens element being adapted to control focus, zoom and ingress light; an image capture element for obtaining image data; a processor element adapted to apply one or more digital processing functions to the image; the processor element being adapted to calculate code data indicative of the tag number.
摘要翻译: 与应用和读取适于存储号码的标签相关联的标签装置。 所述标签包括多个基本相同的二维点阵列,每个阵列指示用于改进标签检测的数量; 每个阵列包括多个簇,每个簇代表指示该数目的一部分的预定符号。 一种蚀刻装置,用于产生点阵图案,包括多个激光源,其保持在限定任何一个或多个矢量格栅或阵列格栅的歧管中。 一种标签读取装置,包括适于控制焦点,变焦和入射光的透镜元件; 用于获得图像数据的图像捕获元件; 适于将一个或多个数字处理功能应用于图像的处理器元件; 所述处理器元件适于计算指示所述标签号的代码数据。
-
公开(公告)号:US20120301869A1
公开(公告)日:2012-11-29
申请号:US13481622
申请日:2012-05-25
CPC分类号: G01N33/56966 , C12M45/07 , G01N15/1459 , G01N2015/149
摘要: A device, system and method for the separation and collection of sperm cells into multiple subpopulations based upon sperm characteristics and for facilitating the collection of multiple subpopulations in limited space. The device can be a redirection device including one or more spaced apart tubes, where each tube has a tube inlet for collecting particles in a flow path, a tube outlet for dispensing the collected particles, and a tube body connecting the tube inlet to the tube outlet for redirecting the particles in the flow path. The device can further include a support for holding each tube in a spaced apart relationship and a securing element for securing the one or more spaced apart tubes to the support.
摘要翻译: 一种用于基于精子特征将精子细胞分离和收集到多个亚群中的装置,系统和方法,并且有助于在有限的空间中收集多个亚群体。 该装置可以是包括一个或多个间隔开的管的重定向装置,其中每个管具有用于在流动路径中收集颗粒的管入口,用于分配收集的颗粒的管出口和将管入口连接到管的管体 出口用于重新定向流路中的颗粒。 该装置还可以包括用于将每个管保持为间隔开的关系的支撑件和用于将一个或多个间隔开的管固定到支撑件的固定元件。
-
58.
公开(公告)号:US20120119401A1
公开(公告)日:2012-05-17
申请号:US12285399
申请日:2008-10-03
申请人: Nicolas Cunningham , Michael Evans , Seol Bang
发明人: Nicolas Cunningham , Michael Evans , Seol Bang
IPC分类号: B29C71/02
CPC分类号: B01J20/3021 , B01J20/20 , B01J20/3035 , B01J20/3042 , B01J20/3078 , C04B35/532 , C04B35/62655 , C04B35/632 , C04B35/63416 , C04B35/63424 , C04B35/63432 , C04B35/63444 , C04B35/63488 , C04B38/0022 , C04B2111/00836 , C04B2235/424 , C04B2235/425 , C04B2235/5409 , C04B35/52 , C04B38/0645
摘要: A porous, carbonaceous body for use in respiratory protection is produced by making a slurry of carbonaceous powder such as carbon black, a polymeric binder such as polyvinyl alcohol and a solvent, drying and grinding the slurry to yield a ground powder, compacting the powder and heat treating the resulting green body. Alternatively, the slurry is only partially dried to produce a paste, which is compacted and then heat treated. A reactive monomer (plasticizer of cross-linking agent) can be added to the polymeric binder.
摘要翻译: 用于呼吸保护的多孔碳质体通过制造碳黑等碳质粉末,聚乙烯醇等聚合物粘合剂和溶剂等来制造,干燥研磨浆料,粉碎粉碎粉末, 热处理生成的生坯。 或者,浆料仅部分干燥以产生糊状物,将其压实然后进行热处理。 可以向聚合物粘合剂中加入反应性单体(交联剂的增塑剂)。
-
公开(公告)号:US20120016588A1
公开(公告)日:2012-01-19
申请号:US13181584
申请日:2011-07-13
CPC分类号: G01V5/104
摘要: Systems, methods, and devices are provided to determine an accurate neutron-gamma density (NGD) measurement for a broad range of formations, including low-hydrogen-index or low-porosity formations and formations with heavy elements. For example, such an NGD measurement may be obtained by emitting neutrons into a formation such that some of the neutrons inelastically scatter off elements of the formation and generate inelastic gamma rays. The neutrons and inelastic gamma rays that return to the downhole tool may be detected. Some characteristics of certain formations are believed to affect the fast neutron transport of the formations. Thus, if a formation has one or more of such characteristics, a correction may be applied to the count rate of neutrons, the count rate of inelastic gamma rays, or the neutron transport correction function, upon which the neutron-gamma density (NGD) may be determined.
摘要翻译: 提供了系统,方法和装置,以确定宽范围地层的精确中子伽马密度(NGD)测量,包括具有重元素的低氢指数或低孔隙度地层和地层。 例如,这样的NGD测量可以通过将中子发射到地层中而获得,使得一些中子非弹性地离开地层的元素并产生非弹性γ射线。 可以检测返回到井下工具的中子和非弹性γ射线。 某些地层的某些特征被认为会影响地层的快速中子运输。 因此,如果形成具有这样的特征中的一个或多个,则可以对中子的计数率,非弹性γ射线的计数率或中子传输校正函数应用校正,中子伽马密度(NGD) 可以确定。
-
公开(公告)号:US08018409B2
公开(公告)日:2011-09-13
申请号:US12356210
申请日:2009-01-20
申请人: Michael Evans , Adam Whitworth
发明人: Michael Evans , Adam Whitworth
IPC分类号: G09G3/32
CPC分类号: H05B33/0809 , H05B33/0803 , H05B33/0812 , H05B33/0815 , H05B33/0818 , Y02B20/343 , Y02B20/346
摘要: An apparatus and method is provided for optimizing LED driver efficiency. The present invention offers low cost solutions for powering LEDs while minimizing overall power dissipation in devices powered by a depletable power source. Low system cost is attained using a charge pump to increase LED drive voltage level and implementing combinations of drive techniques to overcome the inefficiency of the charge pump. A switch bypasses the charge pump when depletable power source output voltage is sufficient to directly drive an LED load. At certain output voltage levels, the switch can be opened causing the charge pump to boost drive voltage. The output voltage may also be PWM modulated to drive the LED load and, at some voltages, the depletable power source may drive the LED load directly. Efficiency levels of 90-97% are attainable.
摘要翻译: 提供了一种用于优化LED驱动器效率的装置和方法。 本发明提供了用于为LED供电的低成本解决方案,同时最小化由可消耗电源供电的设备中的总体功率消耗。 使用电荷泵提高LED驱动电压电平并实现驱动技术的组合以克服电荷泵的低效率来实现低系统成本。 当可切断电源输出电压足以直接驱动LED负载时,开关旁路电荷泵。 在某些输出电压电平下,可以打开开关,使电荷泵升高驱动电压。 输出电压也可以被PWM调制以驱动LED负载,并且在某些电压下,可消耗的电源可以直接驱动LED负载。 效率水平达到90-97%。
-
-
-
-
-
-
-
-
-