公开(公告)号：US07390879B2

公开(公告)日：2008-06-24

申请号：US10226739

申请日：2002-08-23

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K14/00 ,  C07K7/00 ,  A61K39/00

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US07317092B2

公开(公告)日：2008-01-08

申请号：US10066273

申请日：2002-02-01

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David A. Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Ivar J. Kljavin ,  Jennie P. Mather ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Zemin Zhang

IPC分类号： C07K16/00 ,  C07K17/00

CPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K16/40 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  C12P21/06 ,  G01N33/53 ,  Y02A50/473

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20070161558A1

公开(公告)日：2007-07-12

申请号：US11535976

申请日：2006-09-27

申请人： Napoleone Ferrara ,  David Leung

发明人： Napoleone Ferrara ,  David Leung

IPC分类号： A61K38/18 ,  C07K14/475 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/52 ,  A61K38/00

摘要： DNA isolates coding for a vascular endothelial cell growth factor may be used to produce the protein via recombinant expression systems. Such protein is useful therapeutically to treat conditions in which a selective action on the vascular endothelial cells, in the absence of excessive connective tissue proliferation, is desirable.

公开(公告)号：US20070134250A1

公开(公告)日：2007-06-14

申请号：US11537567

申请日：2006-09-29

申请人： Napoleone Ferrara ,  Hans-Peter Gerber ,  Joe Kowalski ,  Maria Pisabarro ,  Daniel Sherman

发明人： Napoleone Ferrara ,  Hans-Peter Gerber ,  Joe Kowalski ,  Maria Pisabarro ,  Daniel Sherman

IPC分类号： A61K39/395 ,  C12Q1/68 ,  A61K38/55

CPC分类号： C07K14/515 ,  A61K48/00 ,  C12N2799/022

摘要： The present invention is directed to methods and means for making and using Angpt13 polypeptides. The invention specifically concerns the use of Angpt13 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angpt13 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.

摘要翻译： 本发明涉及制备和使用Angpt13多肽的方法和手段。 本发明具体涉及Angpt13多肽在诱导肝脏再生和血管生成中的应用。 其他方法包括在诊断和治疗肝脏疾病中使用Angpt13多肽。 本文还提供结合本发明多肽的抗体。

公开(公告)号：US20070122394A1

公开(公告)日：2007-05-31

申请号：US11535049

申请日：2006-09-25

申请人： Napoleone Ferrara ,  Kenneth Hillan ,  Jennifer Le Couter

发明人： Napoleone Ferrara ,  Kenneth Hillan ,  Jennifer Le Couter

IPC分类号： A61K48/00 ,  A61K38/18

CPC分类号： A61K38/1866 ,  A61K48/00 ,  C12N2799/022

摘要： The present invention provides pharmaceutical compositions and methods for liver proliferation and protection. Specifically useful are VEGFR modulating agents capable of promoting liver growth. Disclosed compositions and methods may be useful for promoting proliferation or treating pathological conditions in other organs of significant biological functions.

摘要翻译： 本发明提供了用于肝脏增殖和保护的药物组合物和方法。 特别有用的是能够促进肝脏生长的VEGFR调节剂。 所公开的组合物和方法可用于促进增殖或治疗具有显着生物功能的其它器官中的病理状况。

公开(公告)号：US07196165B2

公开(公告)日：2007-03-27

申请号：US09978375

申请日：2001-10-16

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/00

CPC分类号： C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07189529B2

公开(公告)日：2007-03-13

申请号：US10013927

申请日：2001-10-25

申请人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

发明人： Avi J. Ashkenazi ,  Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Ivar J. Kljavin ,  Sophia S. Kuo ,  Mary A. Napier ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  David L. Shelton ,  Timothy A. Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C12P21/06 ,  C12N1/12 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070031929A1

公开(公告)日：2007-02-08

申请号：US11536590

申请日：2006-09-28

申请人： Napoleone Ferrara ,  Sophia Kuo

发明人： Napoleone Ferrara ,  Sophia Kuo

IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N5/06 ,  C07K14/475

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor (VEGF) and bone morphogenetic protein 1. VEGF-E has homology to VEGF including conservation of the amino acids required for activity of VEGF. VEGF-E can be useful in wound repair, as well as in the generation and regeneration of tissue.

摘要翻译： 本发明涉及血管内皮生长因子-E（VEGF-E）的鉴定和制备。 VEGF-E是与血管内皮生长因子（VEGF）和骨形态发生蛋白1相关的新型多肽.VC-E与VEGF具有同源性，包括对VEGF活性所需氨基酸的保守性。 VEGF-E可用于伤口修复，以及组织的产生和再生。

公开(公告)号：US20060217301A1

公开(公告)日：2006-09-28

申请号：US10549241

申请日：2004-03-12

申请人： Napoleone Ferrara ,  Jennifer Lecouter

发明人： Napoleone Ferrara ,  Jennifer Lecouter

IPC分类号： A61K38/17

CPC分类号： A61K39/3955 ,  A61K38/02 ,  A61K38/1866 ,  A61K38/1891 ,  C12N5/0669

摘要： The present invention provides methods of using Bv8 and EG-VEGF polypeptides and nucleic acids to promote hemtopoiesis. Also provided herein are methods of screening for modulators of Bv8 and EG-VEGF activity. Furthermore, methods of treatment using Bv8 and EG-VEGF polypeptides or Bv8 and EG-VEGF antagonists are provided.

公开(公告)号：US07041805B2

公开(公告)日：2006-05-09

申请号：US10007194

申请日：2001-12-06

申请人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Kevin P. Baker ,  David Botstein ,  Luc Desnoyers ,  Dan L. Eaton ,  Napoleone Ferrara ,  Sherman Fong ,  Wei-Qiang Gao ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin L. Gurney ,  Kenneth J. Hillan ,  James Pan ,  Nicholas F. Paoni ,  Margaret Ann Roy ,  Victoria Smith ,  Timothy A. Stewart ,  Daniel Tumas ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K16/18 ,  C07K17/08 ,  A61K39/395

CPC分类号： C07K14/47 ,  C07K14/705

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.