公开(公告)号：US12221476B2

公开(公告)日：2025-02-11

申请号：US17281874

申请日：2019-10-02

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  ENTHERA S.R.L.

Inventor： Paolo Fiorina ,  Francesca D'Addio ,  Francesca Zagari

IPC: C07K16/22 ,  A61K39/00

Abstract: The present invention relates to an antibody or antigen binding fragment thereof that binds specifically to IGFBP3 and does not displace the binding of IGF-I to IGFBP3. The antibody inhibits or reduces the binding of IGFBP3 to the TMEM219 receptor. The invention also relates to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

公开(公告)号：US20240425851A1

公开(公告)日：2024-12-26

申请号：US18700795

申请日：2022-10-11

Applicant: OSPEDALE SAN RAFFAELE S.R.L. (50%) ,  FONDAZIONE TELETHON ETS (50%)

Inventor： Anna Villa ,  Luigi Naldini ,  Samuele Ferrari ,  Maria Carmina Castiello ,  Simona Porcellini ,  Daniele Canarutto

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/90

Abstract: The present invention relates to an isolated polynucleotide comprising from 5′ to 3′: a first homology region, a nucleotide sequence encoding a RAG1 polypeptide or a RAG1 polypeptide fragment, and a second homology region for use in treating a RAG-deficient immunodeficiency.

公开(公告)号：US20240376197A1

公开(公告)日：2024-11-14

申请号：US18684598

申请日：2022-08-18

Applicant: The Trustees of the University of Pennsylvania ,  Institute of Applied Bioscience (INAB) / Centre For Research and Technology Hellas (CERTH) ,  Ospedale San Raffaele S.R.L. (OSR) ,  Emory University

Inventor： Marco Ruella ,  Stephen Schuster ,  Kostas Stamatopoulos ,  Paolo Prospero Ghia ,  Ignacio Sanz ,  Ivan Cohen

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/705 ,  C07K14/725

Abstract: The present invention relates to compositions and methods for treating or preventing a hematologic cancer or autoimmune disease of a mammal using anti-BCR CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a cancer or autoimmune disease associated with B cells comprising enriched stereotyped BCRs.

公开(公告)号：US11964027B2

公开(公告)日：2024-04-23

申请号：US16606633

申请日：2018-04-20

Applicant: Ospedale San Raffaele S.R.L ,  Fondazione Telethon

Inventor： Anna Christina Kajaste-Rudnitski ,  Carolina Petrillo ,  Bernhard Rudolf Gentner ,  Luigi Naldini ,  Pietro Genovese ,  Giulia Schiroli

IPC: A61K48/00 ,  C07K7/64 ,  C12N5/0789 ,  C12N15/69 ,  C12N15/86

CPC classification number: A61K48/0008 ,  C07K7/645 ,  C12N5/0647 ,  C12N15/69 ,  C12N15/86 ,  C12N2740/15043

Abstract: Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of gene editing of an isolated population of cells when transduced by a viral vector.

公开(公告)号：US11957747B2

公开(公告)日：2024-04-16

申请号：US17143953

申请日：2021-01-07

Applicant: Ospedale San Raffaele S.r.l. ,  Fondazione Telethon ETS

Inventor： Alessio Cantore ,  Angelo Leone Lombardo ,  Luigi Naldini

IPC: A61K39/12 ,  C12N7/04 ,  C12N15/86

CPC classification number: A61K39/12 ,  C12N7/04 ,  C12N15/86 ,  A61K2121/00 ,  C12N2740/10052 ,  C12N2740/16041 ,  C12N2740/16052

Abstract: An enveloped viral particle producer or packaging cell, wherein the cell is genetically engineered to decrease expression of MHC-I on the surface of the cell.

公开(公告)号：US20240101623A1

公开(公告)日：2024-03-28

申请号：US18275151

申请日：2022-02-15

Applicant: Ospedale San Raffaele S.r.l. ,  Consiglio Nazionale Delle Ricerche

Inventor： Vania Broccoli ,  Alessandro Sessa

IPC: C07K14/47 ,  C12N9/10

CPC classification number: C07K14/4703 ,  C12N9/1007 ,  C12Y201/01037 ,  C07K2319/80

Abstract: An epigenetic silencer factor (ESF) comprising a transcription factor DNA-binding domain operably linked to at least one epigenetic effector domain, wherein the transcription factor is an oncogenic transcription factor or a cancer-associated transcription factor.

公开(公告)号：US20230340471A1

公开(公告)日：2023-10-26

申请号：US17963631

申请日：2022-10-11

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Angelo Leone Lombardo ,  Angelo Amabile ,  Alessandro Migliara

IPC: C12N15/113 ,  C12N9/10 ,  C07K14/47 ,  A61K38/45 ,  A61K48/00 ,  A61K35/12 ,  A61K38/17 ,  C12N9/22

CPC classification number: C12N15/113 ,  C12N9/1007 ,  C07K14/4703 ,  C12Y201/01037 ,  C12Y201/01043 ,  A61K38/45 ,  A61K48/005 ,  A61K35/12 ,  A61K38/1709 ,  C12N9/22 ,  C07K2319/80 ,  C12N2740/16043 ,  C12N2310/20 ,  A61K38/00

Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).

公开(公告)号：US20230226304A1

公开(公告)日：2023-07-20

申请号：US17997715

申请日：2021-05-04

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  POLITECNICO DI MILANO

Inventor： Giovanni LANDONI ,  Alberto ZANGRILLO ,  Filippo CONSOLO ,  Alberto REDAELLI ,  Gianfranco Beniamino FIORE ,  Alessandro CAIMI

IPC: A61M16/10 ,  A61M16/00 ,  A61M16/20

CPC classification number: A61M16/107 ,  A61M16/024 ,  A61M16/0066 ,  A61M16/205 ,  A61M16/209 ,  A61M2205/8206

Abstract: A stand-alone continuous positive airways pressure, CPAP, apparatus having a face-mask and a connected electro-mechanical device to supply air to the face-mask is disclosed. The electro-mechanical device includes a pneumatic channel for flowing air to be delivered to the face mask and a control unit for managing the air pressure of the air inside the pneumatic channel. The CPAP apparatus includes a turbine fan, located in the electro-mechanical device housing, connected to the control unit for pressurizing atmospheric air. The pneumatic channel includes an inlet portion located upstream of the turbine fan to receive atmospheric air, and an outlet portion located downstream of the turbine fan to deliver the pressurized air to the face-mask through an outlet opening. The pneumatic channel also longitudinally extends from the inlet portion to the outlet portion.

公开(公告)号：US11548936B2

公开(公告)日：2023-01-10

申请号：US16477829

申请日：2018-01-16

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION ,  OSPEDALE SAN RAFFAELE S.R.L. ,  DANA-FARBER CANCER INSTITUTE, INC. ,  FONDAZIONE TELETHON

Inventor： Alessandra Biffi ,  Eleonora Cavalca

IPC: C07K14/825 ,  G01N33/68

Abstract: The present invention provides compositions and methods for the treatment or prevention of a lysosomal disease or disorder involving increasing the level, expression, or activity of a metallothionein polypeptide or polynucleotide in the subject.

公开(公告)号：US20220402980A1

公开(公告)日：2022-12-22

申请号：US17777228

申请日：2020-11-16

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Flavio CURNIS ,  Angelo CORTI ,  Giovanna MUSCO ,  Michela GHITTI ,  Francesca NARDELLI ,  Alessandro GORI

IPC: C07K14/47 ,  A61K49/00 ,  A61K47/64 ,  A61K51/08

Abstract: The present invention refers to chromogranin A-derived peptides that are potent dual ligands for integrins αvβ6 and avβ8, their therapeutic and diagnostic uses and relative compositions.