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    TWO-PART MITRAL VALVE AND IMPLANT METHOD
    52.
    发明申请
    TWO-PART MITRAL VALVE AND IMPLANT METHOD 审中-公开

    公开(公告)号：US20190142581A1

    公开(公告)日：2019-05-16

    申请号：US16309063

    申请日：2016-06-15

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Silvano Moiso ,  Felice Giuseppe Carlino ,  Paolo Monelli ,  Monica Francesca Achiluzzi

    IPC: A61F2/24

    Abstract: In certain embodiments, a multiple component heart valve prosthesis includes an abutment ring and a removable bioprosthetic heart valve. The abutment ring is configured for attachment at a heart valve annulus location and includes a locking system. The removable bioprosthetic heart valve includes a valve frame and at least one locking feature. The at least one locking feature is configured to be received by the locking system. The bioprosthetic heart valve can be rotated relative to the abutment ring such that the at least one locking feature transitions from a disengaged position to a first engaged position. When in the disengaged position the bioprosthetic heart valve may be removed from the abutment ring, and when rotated to the engaged position the bioprosthetic heart valve is restrained from axial movement relative to the abutment ring.

    Implant device and implantation kit
    53.
    发明授权
    Implant device and implantation kit 有权

    公开(公告)号：US10245141B2

    公开(公告)日：2019-04-02

    申请号：US15310701

    申请日：2014-05-14

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Laura Ghione ,  Paolo Gaschino ,  Monica Francesca Achiluzzi

    IPC: A61F2/24

    Abstract: An implant device (V), such as a heart valve, for implantation in an animal body includes an annular structure and one or more elongated anchoring members deployable to a deployed condition for insertion into an animal body. The anchoring members are retractable from the deployed condition to a rolled up condition wherein the anchoring members protrude radially out from the annular structure of the device (V) to provide anchoring to a body structure (AS) of an animal. In the rolled up condition the anchoring members at least partly protrude axially of the annular structure of the device (V).

    CARDIAC VALVE PROSTHESIS
    56.
    发明申请
    CARDIAC VALVE PROSTHESIS 有权

    公开(公告)号：US20170035565A1

    公开(公告)日：2017-02-09

    申请号：US15298516

    申请日：2016-10-20

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Carla Stacchino ,  Giovanni Bergamasco ,  Gaetano Burriesci ,  Giovanni Righini

    IPC: A61F2/24 ,  A61F2/848

    CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2/2469 ,  A61F2/848 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/001 ,  Y10T29/49833

    Abstract: A prosthesis for implantation at an implantation site proximate a native aortic valve, the implantation site including a valve annulus and a plurality of Valsalva sinuses located distal to the valve annulus. The prosthesis comprises an armature and a valve connected to the armature, wherein the armature includes a proximal portion configured for anchorage to the valve annulus, a distal portion configured to be positioned distal to the Valsalva sinuses when the proximal portion is anchored to the valve annulus, and first, second and third Valsalva sinus anchors each extending between and connecting the proximal and distal portions and arching radially outward between the proximal portion and the distal portion. The Valsalva sinus anchors are positioned so that each can extend into and engage a wall of a different one of the Valsalva sinuses

    Abstract translation: 用于植入位于接近天然主动脉瓣的植入部位的假体，所述植入部位包括位于瓣膜环的远侧的瓣膜环和多个瓦萨尔瓦鼻窦。 所述假体包括电枢和连接到所述电枢的阀，其中所述电枢包括构造成用于锚固到所述瓣膜环的近端部分，所述近端部分构造成当所述近端部分被锚定到所述瓣膜环时被定位在所述Valsalva鼻窦的远侧 以及第一，第二和第三Valsalva窦锚，其各自在近端部分和远端部分之间延伸并连接，并且在近端部分和远端部分之间径向向外拱起。 Valsalva窦锚定位使得每个可以延伸进入和接合不同的Valsalva鼻窦的壁

    Method for preparing biological tissues for use in biological prostheses
    57.
    发明授权
    Method for preparing biological tissues for use in biological prostheses 有权
    制备用于生物假体的生物组织的方法

    公开(公告)号：US09457130B2

    公开(公告)日：2016-10-04

    申请号：US14966675

    申请日：2015-12-11

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Marina Strasly ,  Giovanni Rolando

    IPC: A61K9/00 ,  C12N5/02 ,  C12N5/00 ,  A61F2/02 ,  A61L27/36 ,  A61K35/12

    CPC classification number: A61L27/3687 ,  A61K35/12 ,  A61L27/3683

    Abstract: A method of treating a biological tissue for biological prostheses includes steps of fixation of the biological tissue via a fixing solution including glutaraldehyde and detoxification of the fixed biological tissue via treatment with a detoxifying solution. The detoxification step includes one or both of eliminating phospholipids via treatment with an elimination solution and a treatment with a detoxifying solution. The elimination solution includes 1,2-octanediol and ethanol. The detoxifying solution includes taurine or homocysteic acid.

    Abstract translation: 用于生物假体处理生物组织的方法包括通过包含戊二醛的固定溶液固定生物组织并通过用解毒溶液处理来固定固定的生物组织的步骤。 解毒步骤包括通过用消除溶液处理和用解毒溶液处理来消除磷脂的一种或两种。 消除溶液包括1,2-辛二醇和乙醇。 解毒溶液包括牛磺酸或高半胱氨酸。

    TRANSAPICAL VALVE REPLACEMENT
    58.
    发明申请
    TRANSAPICAL VALVE REPLACEMENT 审中-公开
    通用阀更换

    公开(公告)号：US20160256143A1

    公开(公告)日：2016-09-08

    申请号：US15153475

    申请日：2016-05-12

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Eric Manasse

    IPC: A61B17/00 ,  A61F2/24 ,  A61B17/34

    CPC classification number: A61B17/00234 ,  A61B17/0057 ,  A61B17/3423 ,  A61B2017/00247 ,  A61B2017/00292 ,  A61B2017/00575 ,  A61F2/2436

    Abstract: Techniques for reaching the interior of the heart, such as for aortic valve replacement, can combine elements of percutaneous implantation methods and elements of surgical implantation methods. In some instances, aortic valve replacement may include a dual transapical approach in which a transfemoral approach is used to reach the apex of the patient's heart from inside the left ventricle while a minimally invasive surgical procedure provides access to the exterior of the apex via an intercostal approach.

    Abstract translation: 用于到达心脏内部的技术，例如用于主动脉瓣置换的技术，可以组合经皮植入方法的元件和手术植入方法的元件。 在一些情况下，主动脉瓣置换可以包括双经验方法，其中经股动脉方法用于从左心室内部到达患者心脏的顶点，而微创外科手术通过肋间进入顶点的外部 方法

    Support device for heart valve prostheses
    59.
    发明授权
    Support device for heart valve prostheses 有权
    心脏瓣膜假体支撑装置

    公开(公告)号：US09358105B2

    公开(公告)日：2016-06-07

    申请号：US13835593

    申请日：2013-03-15

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Andrea Marchisio ,  Giovanni Rolando ,  Paolo Gaschino

    IPC: A61F2/24

    CPC classification number: A61F2/2412 ,  A61F2/2427

    Abstract: A support device for implanting a stentless heart valve prosthesis having three leaflets adapted for coapting and defining three corresponding commissures is disclosed. The support device includes a shaft defining a manipulation axis, the shaft having a proximal portion and a distal portion, and three support formations integrally formed and extending from the proximal end of the shaft, the support formations angularly distributed about the manipulation axis of the shaft, such that each of the support formations correspond to locations of each of the commissures of the stentless heart valve prosthesis. The shaft includes a connection portion flexibly connecting the shaft and the support formations to permit a displacement of the manipulation axis with respect to the support formations. The shaft, the plurality of support formations and the connection portion are integrally formed from a single tubular element.

    Abstract translation: 公开了一种用于植入无支架心脏瓣膜假体的支撑装置，其具有三个适用于起皱和限定三个相应连合的小叶。 所述支撑装置包括限定操作轴的轴，所述轴具有近端部分和远端部分，以及从所述轴的近端一体地形成并延伸的三个支撑结构，所述支撑结构围绕所述轴的操纵轴线成角度地分布 ，使得每个支撑结构对应于无支架式心脏瓣膜假体的每个连合的位置。 轴包括连接部分，该连接部分柔性地连接轴和支撑结构，以允许操纵轴相对于支撑结构的位移。 轴，多个支撑结构和连接部分由单个管状元件整体形成。

    EXPANDABLE PROSTHETIC VALVE HAVING ANCHORING APPENDAGES
    60.
    发明申请
    EXPANDABLE PROSTHETIC VALVE HAVING ANCHORING APPENDAGES 审中-公开
    具有锚固附件的可膨胀顶杆

    公开(公告)号：US20140350666A1

    公开(公告)日：2014-11-27

    申请号：US14452849

    申请日：2014-08-06

    Applicant: Sorin Group Italia S.r.l.

    Inventor： Giovanni Righini

    IPC: A61F2/24

    CPC classification number: A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054

    Abstract: A heart valve prosthesis includes an expandable prosthetic valve including three valve leaflets coupled to an anchoring structure. The anchoring structure includes an annular member and a plurality of arms movably coupled to the annular member at one end. The free ends of the arms extend radially away from the prosthesis toward a valve annulus. The arms are configured to fit in a space defined between an open native valve leaflet and a wall of a valve sinus. The arms are sufficiently resilient such that they resist downward movement in response to pressure exerted on the prosthesis, facilitating anchorage and stabilization of the prosthesis at the implantation site.

    Abstract translation: 心脏瓣膜假体包括可扩张假体瓣膜，其包括联接到锚定结构的三个瓣膜小叶。 锚固结构包括环形构件和在一端可移动地联接到环形构件的多个臂。 臂的自由端径向延伸离开假体朝向瓣膜环。 臂配置成装配在开放的天然瓣膜和阀窦壁之间限定的空间中。 臂具有足够的弹性，使得它们抵抗施加在假体上的压力而抵抗向下运动，便于植入部位处的假体的锚固和稳定。

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