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51.发明授权Sheaths reducing recoil and loss of retention for polymer scaffolds crimped to balloons 有权护套减少聚合物支架的后坐力和失去保留力，卷曲到气球公开(公告)号：US09579181B2
公开(公告)日：2017-02-28
申请号：US14716715
申请日：2015-05-19
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Jhoan Bayogo
CPC classification number: A61F2/0095 , A61F2/958 , A61F2/962 , A61F2/97 , A61F2002/011 , A61F2002/9522 , A61F2002/9583 , A61F2240/001 , A61F2250/0059 , B23P11/005 , Y10T29/49826 , Y10T29/49838 , Y10T29/49909 , Y10T29/49915
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. A single piece sheath is placed over the scaffold immediately following crimping of the scaffold to the balloon. The single piece sheath is replaced by a two-piece sheath, which is removed prior to performing a medical procedure using the medical device.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 在将支架压合到气囊之后立即将单件护套放置在支架上方。 单件护套由两件式护套代替，其在使用医疗装置执行医疗程序之前被移除。
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52.发明申请公开(公告)号：US20160158046A1
公开(公告)日：2016-06-09
申请号：US15015945
申请日：2016-02-04
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Yunbing Wang
CPC classification number: A61F2/958 , A61M5/16877 , A61M25/10184 , A61M25/10185 , A61M25/104 , A61M39/24 , A61M2039/2413
Abstract: An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.
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公开(公告)号：US20160157988A1
公开(公告)日：2016-06-09
申请号：US15042045
申请日：2016-02-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , James Oberhauser , Manish Gada
CPC classification number: A61F2/06 , A61L31/041 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
Abstract: A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.
Abstract translation: 公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。 该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。
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54.发明授权Tube expansion processes for semicrystalline polymers to maximize fracture toughness 有权用于半结晶聚合物的管膨胀过程以使断裂韧性最大化公开(公告)号：US09278477B2
公开(公告)日：2016-03-08
申请号：US14480484
申请日：2014-09-08
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lothar W. Kleiner , James P. Oberhauser , Thierry Glauser , David Wrolstad , Yunbing Wang
CPC classification number: B29C61/04 , B29C35/045 , B29C35/0805 , B29C71/0063 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29K2067/046 , B29K2105/258 , B29K2995/004 , B29K2995/006 , B29K2995/0089 , B29L2031/7534
Abstract: Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
Abstract translation: 公开了制造具有改进的断裂韧性的聚合物支架的方法，包括聚合物管的径向膨胀和从膨胀管制造支架。 聚合物管设置在模具内并且可以用辐射加热。 加热管在模具内径向扩张。
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公开(公告)号：US20160038320A1
公开(公告)日：2016-02-11
申请号：US14918318
申请日：2015-10-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Yunbing Wang , Rommel Lumauig , James Oberhauser
CPC classification number: A61F2/958 , A61F2/915 , A61F2002/9522 , B23P11/005 , B23P11/025 , B29C53/02 , B29C2793/0009 , B29K2067/046 , B29K2995/006 , B29L2031/7534 , Y10T29/49865 , Y10T29/49913
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的支架。 支架通过包括一个或多个气囊加压步骤的过程卷曲到气囊。 选择球囊加压步骤以增强对球囊的支架保持性，并且保持围绕卷曲的支架的内表面的气球折叠的相对均匀的布置，使得当气囊膨胀时，支架以均匀的方式膨胀。
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Patent Agency Ranking
公开(公告)号：US20160030212A1
公开(公告)日：2016-02-04
申请号：US14880905
申请日：2015-10-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John Stankus , Yunbing Wang , Mikael Trollsas , Syed Faiyaz Ahmed Hossainy , Michael H. Ngo , Dariush Davalian
IPC: A61F2/915
CPC classification number: A61F2/915 , A61F2210/0004 , A61F2210/0057 , A61F2230/0013 , A61F2230/0054 , A61L31/041 , A61L31/129 , A61L31/141 , A61L31/148
Abstract: Bioabsorbable scaffolds are disclosed with a rigid polymer component and a rubbery polymer component. The rubbery polymer component is miscible, partially miscible, or immiscible with the rigid polymer component.
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57.发明申请CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开控制用于熔融加工的可生物降解聚合物的水分和塑化公开(公告)号：US20150375437A1
公开(公告)日：2015-12-31
申请号：US14852135
申请日：2015-09-11
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding
IPC: B29C47/00
CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/0066 , B29C47/0869 , B29C47/0893 , B29C47/0894 , B29C47/1018 , B29C47/1027 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92333 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006
Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.
Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。 进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。
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58.发明申请Bioabsorbable Stent and Treatment That Elicits Time-Varying Host-Material Response 审中-公开生物可吸收的支架和引起时变主机材料反应的治疗公开(公告)号：US20150313735A1
公开(公告)日：2015-11-05
申请号：US14581993
申请日：2014-12-23
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Richard Rapoza , Yunbing Wang , James P. Oberhauser , Syed Hossainy
CPC classification number: A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
Abstract: Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
Abstract translation: 公开了用生物吸收性支架治疗显示狭窄的患病血管的方法。 植入的支架以增加的直径支撑血管的一段时间，以允许血管愈合。 支架在植入后6个月内失去足以支撑血管的部分的径向强度，丧失机械完整性，然后从该部分脱落。 生物降解支架随着支架退化而导致斑块的性质随时间的变化。 时间依赖性质包括斑块和斑块几何形态参数的腔面积。
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59.发明申请METHOD TO MINIMIZE MOLECULAR WEIGHT DROP OF POLY(L-LACTIDE) STENT DURING PROCESSING 审中-公开在加工过程中最小化聚（L-LACTIDE）STENT分子量降低的方法公开(公告)号：US20150054202A1
公开(公告)日：2015-02-26
申请号：US14530151
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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公开(公告)号：US20140228930A1
公开(公告)日：2014-08-14
申请号：US14254812
申请日：2014-04-16
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： John E. Papp , Mikael Trollsas , Dariush Davalian , Yunbing Wang , Syed Faiyaz Ahmed Hossainy
IPC: A61F2/89
CPC classification number: A61F2/89 , A61F2/915 , A61F2002/825 , A61F2002/828 , A61F2002/91558 , A61F2002/91575 , A61F2220/005 , A61F2230/0013 , A61F2230/0054
Abstract: Stent scaffolds that include a polymeric structure or structures bonded to the scaffold and extending along their length are disclosed. The polymeric structure extends across some or all of the gaps in struts along the length of the scaffold. Segmented scaffolds are also disclosed that include two or more axial segments arranged end to end not connected by link sruts.
Abstract translation: 公开了包括结合到支架上并沿其长度延伸的聚合物结构或结构的支架。 聚合物结构沿着支架的长度延伸穿过支柱中的一些或全部间隙。 还公开了分段支架，其包括端对端布置的两个或更多个轴向段，其不被连接部分连接。
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