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公开(公告)号：US11112593B2
公开(公告)日：2021-09-07
申请号：US16804957
申请日：2020-02-28
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
IPC: G02B21/00 , G01N1/28 , G01N1/38 , G01N21/31 , G01N33/49 , G02B21/36 , B01L3/00 , G01N15/06 , G02B21/34 , G01N15/00 , B01L3/02 , G01N1/40 , G01N15/14 , G01N35/10 , G01N35/00
Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.
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公开(公告)号：US20200371004A1
公开(公告)日：2020-11-26
申请号：US16994124
申请日：2020-08-14
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay
Abstract: Among other things, a diluted sample is generated based on mixing a small sample of blood with a one or more diluents. A thin film of the diluted sample is formed on the surface of a contact optical microscopy sensor. Red blood cells within a portion of the thin film of the diluted sample are illuminated using light of a predetermined wavelength. One or more images of the diluted sample are acquired based on illuminating the red blood cells within the portion of the thin film of the diluted sample. The acquired one or more images of the diluted sample are then processed. The mean corpuscular hemoglobin in the red blood cells within the portion of the thin film of the diluted sample is determined based on processing the acquired images of the diluted sample.
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公开(公告)号：US10809512B2
公开(公告)日：2020-10-20
申请号：US16455539
申请日：2019-06-27
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
IPC: G02B21/34 , G01N21/59 , G01N1/40 , G01N15/06 , G01N1/28 , G01N15/14 , G01N33/49 , G01N35/00 , G01N15/00 , G01N15/10
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
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公开(公告)号：US10753851B2
公开(公告)日：2020-08-25
申请号：US16197265
申请日：2018-11-20
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
Abstract: Among other things, an imaging sensor includes a two-dimensional array of photosensitive elements and a surface to receive a sample within a near-field distance of the photosensitive elements. Electronics classify microbeads in the sample as belonging to different classes based on the effects of different absorption spectra of the different classes of microbeads on light received at the surface. In some examples, the number of different distinguishable classes of microbeads can be very large based on combinations of the effects on light received at the surface of the different absorption spectra together, spatial arrangements of colorants in the microbeads that impart the different absorption spectra, different sizes of microbeads, and different shapes of microbeads, among other things.
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公开(公告)号：US20200174238A1
公开(公告)日：2020-06-04
申请号：US16701078
申请日：2019-12-02
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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Patent Agency Ranking
公开(公告)号：US20200073101A1
公开(公告)日：2020-03-05
申请号：US16573565
申请日：2019-09-17
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号：US20190333955A1
公开(公告)日：2019-10-31
申请号：US16282501
申请日：2019-02-22
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Madhuranga Srinath Rankaduwa
IPC: H01L27/146 , G01N21/27 , G01N33/49
Abstract: Among other things, an integral image sensor includes a sensor surface having a surface area at which light-sensitive pixels are arranged in rows and columns. The surface area includes two or more light-sensitive subareas each of the subareas having been configured to have been diced from a wafer along two orthogonal dimensions to form a discrete image sensor. The two or more light-sensitive subareas are arranged along one of the two orthogonal dimensions. The sensor surface of the integral image sensor is flat and continuous across the two or more subareas.
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公开(公告)号：US20190324258A1
公开(公告)日：2019-10-24
申请号：US16455482
申请日：2019-06-27
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
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公开(公告)号：US20190317309A1
公开(公告)日：2019-10-17
申请号：US16455539
申请日：2019-06-27
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
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公开(公告)号：US10345564B2
公开(公告)日：2019-07-09
申请号：US16113578
申请日：2018-08-27
Applicant: Alentic Microscience Inc.
Inventor： Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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