Abstract:
The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
Abstract:
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract:
The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Abstract:
A system and method of adding hyperlinked information to a television broadcast in which an interactive content icon is used. The broadcast material is analyzed and one or more regions within a frame are identified. Additional information can be associated with a region, and can be transmitted in encoded form, using timing information to identify the frame with which the information is associated. The system comprising a video source and an encoder that produces a transport stream in communication with the video source, an annotation source, a data packet stream generator that produces encoded annotation data packets in communication with the annotation source and the encoder, and a multiplexer system in communication with the encoder and the data packet stream generator. The encoder provides timestamp information to the data packet stream generator and the data packet stream generator synchronizes annotation data from the annotation source with a video signal from the video source in response to the timestamp information. The multiplexer generates a digital broadcast signal that includes an augmented transport stream from the transport stream and the encoded data packets. A receiver displays the annotation information associated with the video signal in response to a viewer request on a frame by frame basis. A viewer can respond interactively to the material, including performing commercial transactions, by using a backchannel that is provided for interactive communication. The interactive content icon can be used to inform a viewer of the presence of hyperlinked information, for teaching the viewer how to use the system, and for informing the viewer about the hyperlinked information.
Abstract:
A system and method of adding hyperlinked information to a television broadcast in which an interactive content icon is used. The broadcast material is analyzed and one or more regions within a frame are identified. Additional information can be associated with a region, and can be transmitted in encoded form, using timing information to identify the frame with which the information is associated. The system comprising a video source and an encoder that produces a transport stream in communication with the video source, an annotation source, a data packet stream generator that produces encoded annotation data packets in communication with the annotation source and the encoder, and a multiplexer system in communication with the encoder and the data packet stream generator. The encoder provides timestamp information to the data packet stream generator and the data packet stream generator synchronizes annotation data from the annotation source with a video signal from the video source in response to the timestamp information. The multiplexer generates a digital broadcast signal that includes an augmented transport stream from the transport stream and the encoded data packets. A receiver displays the annotation information associated with the video signal in response to a viewer request on a frame by frame basis. A viewer can respond interactively to the material, including performing commercial transactions, by using a backchannel that is provided for interactive communication. The interactive content icon can be used to inform a viewer of the presence of hyperlinked information, for teaching the viewer how to use the system, and for informing the viewer about the hyperlinked information.
Abstract:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract:
A rich client view of server data is integrated within a server presentation of data provided by a portal server application. The rich client view of data is included with other web based views provided according to the server presentation of data when the rich client view is created. The rich client view is integrated among the web based views such that the rich client view and web based views are organized together. A separate application is launched to render the rich client view in response to a selection to render the rich client view. The selection to render the rich client view is integrated within the server presentation of data such that rich client view is provided seamlessly within the server presentation.
Abstract:
Provided is an apparatus and method for customization of a protective device. The apparatus and method includes coupling programmer programmable memory to a microprocessor for processing select logic schemes. The programmer programmable memory is adapted to be modifiable by only a programmer of said protective device. Elements associated with some of the logic schemes are implemented into the programmer programmable memory in the form of a compiled settings structure having a plurality of allocation fields.
Abstract:
Database interaction is facilitated by graphically presenting database objects in groups that are not necessarily dictated by object types of the database objects. In an example implementation, database navigation is facilitated by determining object dependency groups for a database in which each object dependency group corresponds to a database source object and includes at least those database objects that depend directly or indirectly from the corresponding database source object. When these data source object-based dependency groups are graphically displayed, selecting a database object thereof provides access thereto. In another example implementation, a user can designate an attribute associated with database objects by which the database objects are to be grouped. Thus, the database objects are grouped by various values that the user-designated associated attribute takes. These designated-attribute-based value-driven groups may also be graphically displayed to enable navigation of and access to the different database objects assigned to them.