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    Trisbenzimidazoles useful as topoisomerase I inhibitors
    56.
    发明授权
    Trisbenzimidazoles useful as topoisomerase I inhibitors 失效
    可用作拓扑异构酶I抑制剂的三苯并咪唑

    公开(公告)号：US5767142A

    公开(公告)日：1998-06-16

    申请号：US618988

    申请日：1996-03-20

    申请人： Edmond J. LaVoie ,  Leroy Fong Liu ,  Qun Sun

    发明人： Edmond J. LaVoie ,  Leroy Fong Liu ,  Qun Sun

    IPC分类号： C07D235/18 ,  C07D401/14 ,  A61K31/415

    CPC分类号： C07D401/14 ,  C07D235/18

    摘要： The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: ##STR1## wherein Ar is (C.sub.6 -C.sub.12)aryl or (5- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C.sub.1 -C.sub.4)alkyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each Y is individually H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H or (C.sub.1 -C.sub.4)alkyl; n is 0 or 1; and each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; or a pharmaceutically acceptable salt therein.

    摘要翻译： 本发明提供下式的抗肿瘤拓扑异构酶I抑制剂：其中Ar是（C 6 -C 12）芳基或包含1-3个N，S或非过氧化物O的（5-至12-元）杂芳基，其中 N是未取代的或被（C 1 -C 4）烷基取代; X是H，CN，CHO，OH，乙酰基，CF 3，O（C 1 -C 4）烷基，NO 2，NH 2，卤素或卤代（C 1 -C 4） 每个Y各自为H，（C 1 -C 4）烷基或芳烷基; Y'是H或（C 1 -C 4）烷基; n为0或1; 并且每个Z独立地为H，（C 1 -C 4）烷基，卤素或卤素（C 1 -C 4）烷基; 或其药学上可接受的盐。

    METHOD FOR PREVENTING PRESSURE BUILD UP IN A CATALYST SEPARATION SYSTEM
    57.
    发明申请
    METHOD FOR PREVENTING PRESSURE BUILD UP IN A CATALYST SEPARATION SYSTEM 审中-公开
    用于防止在催化分离系统中建立压力的方法

    公开(公告)号：US20140206907A1

    公开(公告)日：2014-07-24

    申请号：US14128309

    申请日：2012-06-22

    申请人： Jason C. Gause ,  Gregg M. Sisler ,  Qun Sun

    发明人： Jason C. Gause ,  Gregg M. Sisler ,  Qun Sun

    IPC分类号： C08G65/26

    CPC分类号： C08G65/2696 ,  Y02P20/584

    摘要： A method for preventing pressure build-up across a catalyst separation in a polyether polyol reactor comprising the steps of feeding reactants that comprise a monomer or co-monomers to be polymerized to form the polyether polyol into a continuous feed reactor, flowing the product stream through a catalyst separation system within the reactor, wherein the catalyst separation system is comprised of a plurality of filters, wherein each filter comprises an outer surface and an inner surface defined by a plurality of spaced-apart elements, and wherein the distance between the spaced-apart elements is smaller than the minor dimension of the suspended catalyst and recovering the filtered polyether polyol product and catalyst fines from the reactor outlet.

    摘要翻译： 一种用于防止在聚醚多元醇反应器中催化剂分离的压力累积的方法，包括以下步骤：将包含待聚合的单体或共聚单体的反应物进料到连续进料反应器中，使产物流通过 反应器内的催化剂分离系统，其中催化剂分离系统由多个过滤器组成，其中每个过滤器包括由多个间隔开的元件限定的外表面和内表面，并且其中， 分离的元素小于悬浮催化剂的次要尺寸，并从反应器出口回收过滤的聚醚多元醇产物和催化剂细粒。

    Color correction circuitry and methods for dual-band imaging systems
    58.
    发明授权
    Color correction circuitry and methods for dual-band imaging systems 有权
    双频成像系统的色彩校正电路和方法

    公开(公告)号：US08357899B2

    公开(公告)日：2013-01-22

    申请号：US12848086

    申请日：2010-07-30

    申请人： Changmeng Liu ,  Yingjun Bai ,  Qun Sun

    发明人： Changmeng Liu ,  Yingjun Bai ,  Qun Sun

    IPC分类号： H01L25/00

    CPC分类号： H04N5/332 ,  H04N9/735

    摘要： An imaging system may include a dual-band image sensor that captures visible and near-infrared light and image processing circuitry that performs color corrections on images captured by the dual-band image sensor. The image processing circuitry may analyze each captured image in two different color spaces to determine what type of light source lit each image. The image processing circuitry may determine whether an image was lit by a light source having a relatively high proportion of near-infrared emissions such as an incandescent light, a light source having a relatively low proportion of near-infrared emissions such as a fluorescent light, or a light source having an intermediate proportion of near-infrared emissions such as sunlight or other blackbody radiator. After determining what type of light source lit an image, the image processing circuitry may adjust color balances in that image using a color correction matrix associated with that type of light source.

    摘要翻译： 成像系统可以包括捕获可见光和近红外光的双频带图像传感器和对由双频带图像传感器捕获的图像执行颜色校正的图像处理电路。 图像处理电路可以分析两个不同颜色空间中的每个拍摄图像，以确定点亮每个图像的什么类型的光源。 图像处理电路可以确定图像是否由具有相对高比例的近红外发射的光源照射，例如白炽灯，具有相对较低比例的近红外发射的光源，例如荧光灯， 或具有中等比例的近红外发射的光源例如太阳光或其他黑体散热器。 在确定什么类型的光源点亮图像之后，图像处理电路可以使用与该类型的光源相关联的颜色校正矩阵来调整该图像中的色彩平衡。

    Therapeutic agents useful for treating pain
    59.
    发明授权
    Therapeutic agents useful for treating pain 有权

    公开(公告)号：US08349842B2

    公开(公告)日：2013-01-08

    申请号：US12506040

    申请日：2009-07-20

    申请人： Qun Sun ,  Kate Xin Wen ,  Xiaoming Zhou

    发明人： Qun Sun ,  Kate Xin Wen ,  Xiaoming Zhou

    IPC分类号： A61K31/497

    CPC分类号： C07D417/14 ,  C07D401/04

    摘要： Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperidine Compound are disclosed. In one embodiment, the Piperidine Compound has the formula: and pharmaceutically acceptable salts thereof, wherein Ar1, Ar2, X, R3, R4, and m are as disclosed herein.

    Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof
    60.
    发明申请
    Compounds as TRVP1 Blockers, Pharmaceutical Compositions and Medical Uses Thereof 失效
    化合物作为TRVP1阻断剂，药物组合物及其用途

    公开(公告)号：US20120184509A1

    公开(公告)日：2012-07-19

    申请号：US13498641

    申请日：2010-09-27

    申请人： Qun Sun

    发明人： Qun Sun

    IPC分类号： A61K31/695 ,  A61P29/00 ,  C07F7/10

    CPC分类号： C07F7/0814 ,  A01N55/00 ,  A61K31/695 ,  C07F7/0812

    摘要： A kind of new compounds, and their pharmaceutically acceptable salts, and hydrates are disclosed. The pharmaceutical composition thereof is also provided. And also are the medical uses of the compounds, pharmaceutically acceptable salts, hydrates and the pharmaceutical composition for treating the TRPV1-mediate diseases.

    摘要翻译： 公开了一种新的化合物及其药学上可接受的盐和水合物。 还提供了其药物组合物。 也是化合物，药学上可接受的盐，水合物和用于治疗TRPV1介导性疾病的药物组合物的医学用途。