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公开(公告)号：US11932838B2
公开(公告)日：2024-03-19
申请号：US17746473
申请日：2022-05-17
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner , Alexander Meyer Wilks
CPC classification number: C12M23/08 , C12M23/20 , C12N5/0682
Abstract: This disclosure provides a cell culture media extending material capable of releasing nutrients into the cell culture environment slowly overtime. In embodiments, this material is a part of a cell culture vessel. In embodiments, the material is a coating or a film on a surface of a cell culture material. In additional embodiments, the material is a surface upon which cells are cultured, such as a cell culture vessel or a microcarrier.
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公开(公告)号：US20230416664A1
公开(公告)日：2023-12-28
申请号：US18037229
申请日：2021-11-17
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Allison Jean Tanner
Abstract: Cell culture devices comprise a frame comprising an open well disposed therein and a fluid inlet area in communication with the open well. The open well comprises a top opening, a bottom plate comprising a microcavity substrate, the bottom plate defining a major surface, and one or more sidewalls extending from the bottom plate to the top opening. The microcavity substrate comprises a plurality of microcavities, and each microcavity is configured such that cells cultured in the well form a spheroid. The cell culture device may be a reservoir open well microcavity plate used for spheroid cell culture.
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公开(公告)号：US20230330600A1
公开(公告)日：2023-10-19
申请号：US18018987
申请日：2021-07-28
Applicant: CORNING INCORPORATED
Inventor： Ana Maria del Pilar Pardo , Allison Jean Tanner
CPC classification number: B01D61/18 , B01D61/145 , B01D71/68 , B01D63/16 , B01D69/02 , B01D67/0088 , B01L3/5021 , B01D2325/34 , B01L2300/0681 , B01L2300/042
Abstract: A coated ultrafiltration device comprises an upper chamber; a lower chamber; a filtration chamber disposed between the upper chamber and lower chamber; and a semipermeable membrane disposed substantially vertically around the filtration chamber. The semipermeable membrane comprises a coating on a portion of the semipermeable membrane exposed to the filtration chamber, wherein the coating comprises an ultra-low attachment coating that is not derived from animal sources.
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公开(公告)号：US20230323265A1
公开(公告)日：2023-10-12
申请号：US18023227
申请日：2021-08-26
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture system is provided that includes at least one multi-layered vessel for culturing cells, and a cabinet comprising an interior cavity enclosed by one or more sidewalls. The cabinet being configured to house the multi-layered vessel within the interior cavity. The multi-layered vessel includes a cell culture space within the multi-layered vessel. The cabinet can change an orientation of the multi-layered vessel from an upright orientation to a tilted orientation.
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公开(公告)号：US20230279323A1
公开(公告)日：2023-09-07
申请号：US18195166
申请日：2023-05-09
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Allison Jean Tanner
CPC classification number: C12M23/12 , B01L3/50273 , C12M23/38 , C12M25/04 , B01L2200/027 , B01L2300/0864 , B01L2300/123 , B01L2400/0475
Abstract: A fluidic device for culturing cells includes a microplate and plate lid. The microplate includes multiple wells and channels, the channels extending between the wells such that the channels interconnect the wells. The plate lid releasably engages the microplate to thereby enclose the wells and the channels. The wells include a culture surface such that a cell culture medium received therein is deposited over the culture surface. At least one channel that extends between adjacent ones of the wells is spaced from the culture surfaces of the adjacent wells defining a gap between the at least one channel and the culture surfaces of the adjacent wells for collection of the cell culture medium.
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Patent Agency Ranking
公开(公告)号：US11684064B2
公开(公告)日：2023-06-27
申请号：US15774883
申请日：2016-11-03
Applicant: Corning Incorporated
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
CPC classification number: A01N1/0268 , B01L3/5082 , B01L3/50825 , C12M45/22 , B01L2200/141 , B01L2300/042 , B01L2300/043 , B01L2300/046 , B01L2300/0609 , B01L2300/0832 , B01L2300/0858 , B01L2300/123
Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
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公开(公告)号：US20220259540A1
公开(公告)日：2022-08-18
申请号：US17734660
申请日：2022-05-02
Applicant: CORNING INCORPORATED
Inventor： Feng Li , Allison Jean Tanner
Abstract: A cell culture well insert may include a frame defining a first open end, a second open end, and at least one support extending therebetween. The cell culture well insert may also include a fluid permeable mesh coupled to the frame and disposed across the second open end. The mesh may define pores that have an average pore size in a range from 10 micrometers to 100 micrometers.
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公开(公告)号：US20220220434A1
公开(公告)日：2022-07-14
申请号：US17613994
申请日：2020-05-22
Applicant: CORNING INCORPORATED
Inventor： Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: The present disclosure relates to agarose and methylcellulose storage and transport mediums, systems for cell storage and transport, and cell storage and transport methods. The instantly-disclosed agarose and methylcellulose storage and transport medium is ideally suited for 3D spheroid cell culture storage and transport. In particular aspects, the storage and transport mediums, systems, and methods are used in combination with or performed in labware that combine 3D spheroid culture with a gas permeable, micro-patterned design that allows for protection and prolonged maintenance of spheroid cell (e.g. hepatocytes) viability and functionality during storage and transport.
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公开(公告)号：US20220081661A1
公开(公告)日：2022-03-17
申请号：US17532196
申请日：2021-11-22
Applicant: CORNING INCORPORATED
Inventor： Ye Fang , Ann MeeJin Ferrie , Vasiliy Nikolaevich Goral , Allison Jean Tanner , Qi Wu
Abstract: A cell culture apparatus may include a substrate defining a well. The well may define an interior surface, an exterior surface, an upper aperture and a nadir. The substrate may define a thickness between the interior and exterior surfaces that has a thickness proximate the nadir that is greater than or equal to a thickness proximate the upper aperture.
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公开(公告)号：US20210292696A1
公开(公告)日：2021-09-23
申请号：US16332608
申请日：2017-09-21
Applicant: Corning Incorporated
Inventor： Gregory Roger Martin , Allison Jean Tanner
Abstract: Multi-layer cell culture devices and systems for culturing suspension and adherent cells via continuous gravity flow of culture media without the use of motorized equipment minimize the risk of contamination of the cell culture. A multi-layer cell culture device includes at least first and second chambers configured to contain fluid and to be fluidly connected such that fluid in the first chamber unidirectionally and continuously flows by gravity flow from the first chamber and into the second chamber. A multi-layer cell culture device can further include a third chamber configured to contain fluid and positioned below the second chamber such that fluid in the second chamber unidirectionally and continuously flows by gravity flow from the second chamber and into the third chamber. Methods of culturing cells using these devices and systems are also described.
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