公开(公告)号：US09136805B2

公开(公告)日：2015-09-15

申请号：US14039208

申请日：2013-09-27

申请人： Dan Li ,  Hui Shen ,  Yang Pan

发明人： Dan Li ,  Hui Shen ,  Yang Pan

IPC分类号： H03F3/04 ,  H03G3/00 ,  H03F3/217

CPC分类号： H03F3/2175 ,  H03F1/025 ,  H03F3/217

摘要： A multi-level amplifier including a converter circuit being supplied with a supply voltage and operable to generate at least two output voltages, a voltage comparator circuit adapted to compare each of the output voltages with the supply voltage to generate a driving signal, and an amplifier circuit being supplied with an analog input signal, the amplifier circuit including an analog-to-digital converter coupled to a power stage driver and power stage, wherein the power stage driver receives the driving signal from the voltage comparator.

摘要翻译： 一种多电平放大器，包括被提供有电源电压并可操作以产生至少两个输出电压的转换器电路，电压比较器电路，其适于将每个输出电压与电源电压进行比较以产生驱动信号;以及放大器 电路被提供有模拟输入信号，放大器电路包括耦合到功率级驱动器和功率级的模数转换器，其中功率级驱动器接收来自电压比较器的驱动信号。

公开(公告)号：US09084898B2

公开(公告)日：2015-07-21

申请号：US13569208

申请日：2012-08-08

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/36564 ,  A61N1/3962

摘要： Various system embodiments comprise at least one sensor input adapted to receive at least one sensed signal associated with a tachyarrhythmia, a feature set extractor adapted to extract at least two features from the at least one sensed signal associated with the tachyarrhythmia, a feature set generator adapted to form a feature set using the at least two features extracted by the feature set extractor, at least one generator adapted for use to selectively apply an anti-tachycardia pacing (ATP) therapy and a neural stimulation (NS) therapy, and a controller adapted to respond to the feature set. The controller is adapted to initiate the NS therapy when the feature set corresponds to criteria for applying the NS therapy to modify the tachyarrhythmia, and initiate the ATP therapy to terminate the modified tachyarrhythmia. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括适于接收与快速性心律失常相关联的至少一个感测信号的至少一个传感器输入，适于从与快速性心律失常相关联的至少一个感测信号中提取至少两个特征的特征集提取器，适于 以使用由所述特征集提取器提取的所述至少两个特征来形成特征集合，适于用于选择性地应用抗心动过速起搏（ATP）治疗和神经刺激（NS）治疗）的至少一个发生器，以及适于 以响应功能集。 当特征集合对应于应用NS治疗来修改快速性心律失常的标准时，控制器适于启动NS治疗，并且启动ATP治疗以终止改变的快速性心律失常。 本文提供了其它方面和实施例。

公开(公告)号：US20150091644A1

公开(公告)日：2015-04-02

申请号：US14039208

申请日：2013-09-27

申请人： Dan Li ,  Hui Shen ,  Yang Pan

发明人： Dan Li ,  Hui Shen ,  Yang Pan

IPC分类号： H03F3/217

CPC分类号： H03F3/2175 ,  H03F1/025 ,  H03F3/217

摘要： A multi-level amplifier including a converter circuit being supplied with a supply voltage and operable to generate at least two output voltages, a voltage comparator circuit adapted to compare each of the output voltages with the supply voltage to generate a driving signal, and an amplifier circuit being supplied with an analog input signal, the amplifier circuit including an analog-to-digital converter coupled to a power stage driver and power stage, wherein the power stage driver receives the driving signal from the voltage comparator.

摘要翻译： 一种多电平放大器，包括被提供有电源电压并可操作以产生至少两个输出电压的转换器电路，电压比较器电路，其适于将每个输出电压与电源电压进行比较以产生驱动信号;以及放大器 电路被提供有模拟输入信号，放大器电路包括耦合到功率级驱动器和功率级的模数转换器，其中功率级驱动器接收来自电压比较器的驱动信号。

公开(公告)号：US08855763B2

公开(公告)日：2014-10-07

申请号：US13077229

申请日：2011-03-31

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3621 ,  A61N1/365

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including ATP. When a tachyarrhythmia episode is detected, the implantable medical device analyzes the morphology of a cardiac signal to determine whether and/or when to deliver an ATP therapy. In various embodiments, the implantable medical device produces morphological parameters indicative of the likeliness of success of the ATP therapy and selects an anti-tachyarrhythmia therapy mode based on the morphological parameters. In various embodiments, the implantable medical device also controls the timing of the ATP therapy delivery using morphological features of the cardiac signal to maximize the probability that the ATP therapy is delivered into an ATP window during which a tachyarrhythmia episode can be effectively terminated by pacing.

摘要翻译： 心律管理（CRM）系统包括可植入医疗装置，其传递包括ATP在内的抗慢性心律失常治疗。 当检测到快速性心律失常发作时，可植入医疗装置分析心脏信号的形态以确定是否和/或何时递送ATP治疗。 在各种实施例中，可植入医疗装置产生指示ATP治疗成功的可能性的形态学参数，并且基于形态参数选择抗快速性心律失常治疗模式。 在各种实施例中，可植入医疗装置还使用心脏信号的形态学特征来控制ATP治疗递送的时间，以使ATP治疗被递送到ATP窗口的可能性最大化，在此期间可以通过起搏有效地终止快速性心律失常发作。

公开(公告)号：US08838240B2

公开(公告)日：2014-09-16

申请号：US12283234

申请日：2008-09-10

申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61B5/0464 ,  A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determined based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。

公开(公告)号：US08712525B2

公开(公告)日：2014-04-29

申请号：US12877583

申请日：2010-09-08

申请人： Dan Li ,  Cheng Zhang

发明人： Dan Li ,  Cheng Zhang

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/3712

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.

摘要翻译： 心律管理（CRM）系统包括可植入的医疗装置，其传递抗心律失常疗法，包括抗心动过速起搏（ATP）和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统，其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时，可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。

公开(公告)号：US20140088312A1

公开(公告)日：2014-03-27

申请号：US14118158

申请日：2011-09-14

申请人： Dan Li ,  Xiaoping Zhou ,  Jie Liu

发明人： Dan Li ,  Xiaoping Zhou ,  Jie Liu

IPC分类号： C07F15/04 ,  C07F1/08 ,  C07F13/00 ,  C07F3/06

CPC分类号： C07F15/045 ,  B01D2253/204 ,  B01D2257/504 ,  B01J20/22 ,  B01J20/226 ,  C07F1/005 ,  C07F1/08 ,  C07F3/00 ,  C07F3/06 ,  C07F13/005

摘要： The present invention discloses zeolite metal bis(imidazole) coordination polymers and preparation method thereof. The new class of zeolite coordination polymers of the present invention is a chemical compound with the following general chemical formula {[M(Blm)]×xDMF×yC2H6O×zH2O}∞, in which when M=Zn, x=0.9, y=0, z=0; when M=Cu, x=1.2, y=0, z=0; when M=Mn, x=2.0, y=0, z=0; when M=Ni, x=0.4, y=1.2, z=1.0, Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide, H2O is water. A solvothermal method or slow diffusion is used on the compounds to obtain crystals of high purity. The coordination polymers of the present invention have good thermal stability, and have strong adsorption performance for CO2 under conditions of 0° C. and normal pressure as adsorbent materials.

摘要翻译： 本发明公开了沸石金属双（咪唑）配位聚合物及其制备方法。 本发明的新型沸石配位聚合物是具有以下一般化学式{[M（Blm）]×xDMF×yC2H6O×zH2O}∞的化合物，其中当M = Zn时，x = 0.9，y = 0，z = 0; 当M = Cu时，x = 1.2，y = 0，z = 0; 当M = Mn时，x = 2.0，y = 0，z = 0; 当M = Ni时，x = 0.4，y = 1.2，z = 1.0，Blm是1,2-双（（5H-咪唑-4-基）亚甲基）肼，DMF是N，N-二甲基甲酰胺，H 2 O是水 。 在化合物上使用溶剂热法或缓慢扩散以获得高纯度的晶体。 本发明的配位聚合物具有良好的热稳定性，在0℃和常压作为吸附材料的条件下对CO 2具有很强的吸附性能。

公开(公告)号：US08649860B2

公开(公告)日：2014-02-11

申请号：US12781459

申请日：2010-05-17

申请人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

发明人： Yanting Dong ,  David L. Perschbacher ,  Jeffrey E. Stahmann ,  Dan Li ,  Deepa Mahajan

IPC分类号： A61N1/39

CPC分类号： A61N1/37252 ,  A61B5/02 ,  A61B5/04 ,  A61B5/0452 ,  A61B5/6846 ,  A61N1/025 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/372 ,  A61N1/3925

摘要： Monitoring physiological parameter using an implantable physiological monitor in order to detect a condition predictive of a possible future pathological episode and collecting additional physiological data associated with the condition predictive of a possible future pathological episode. Monitoring another physiological parameter in order to detect a condition indicative of the beginning of a present pathological episode and collecting additional pathological data in response to the condition. Determining that the condition predictive of a future episode and the condition indicative of a present episode are associated and, in response thereto, storing all the collected physiological data.

摘要翻译： 使用植入式生理监测器监测生理参数，以便检测预测可能的未来病理发作的状况并收集与预测可能的未来病理发作相关的条件相关的附加生理数据。 监测另一个生理参数，以便检测指示本病理发作开始的病症，并根据病情收集额外的病理资料。 确定预测未来事件的状况和指示当前情节的状况是相关联的，并且响应于此，存储所有收集的生理数据。

公开(公告)号：US08620429B2

公开(公告)日：2013-12-31

申请号：US13457630

申请日：2012-04-27

申请人： Dan Li ,  Jaeho Kim ,  Joseph M. Bocek

发明人： Dan Li ,  Jaeho Kim ,  Joseph M. Bocek

IPC分类号： A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/368 ,  A61N1/3688

摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.

摘要翻译： 植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。 如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式根据检测到的快速性心律失常的特点。 并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。 在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间 心房和心室起搏脉冲同时传递，但可以独立计时。

公开(公告)号：US20130342023A1

公开(公告)日：2013-12-26

申请号：US13821267

申请日：2011-03-11

申请人： Dan Li ,  Yangtao Dang ,  Hui Sun ,  Depeng Diao ,  Xuetao Huang ,  Bao Liu

发明人： Dan Li ,  Yangtao Dang ,  Hui Sun ,  Depeng Diao ,  Xuetao Huang ,  Bao Liu

IPC分类号： H04B5/00

CPC分类号： H04B5/0037 ,  H02J5/005 ,  H02J7/025 ,  H02J50/10 ,  H02J50/40 ,  H02J50/80 ,  H04B5/0081

摘要： There is provided a wireless power supplying device and method. The device includes a control part and at least one transmitting part connected with the control part. The control part includes a control circuit and a power supply module. The control circuit is used to determine the power requirement of the transmitting part connected with the control part and control the power supply module to transmit an electrical signal satisfying the power requirement to the transmitting part. The transmitting part generates a magnetic field based on the electrical signal and supplies power to a load of a receiver. The wireless power supply device and method enable each coil to generate electromagnetic induction with desired power, to supply power for the receiver reasonably, and reduce the number and the complexity of the transmitting part.

摘要翻译： 提供了一种无线供电装置和方法。 该装置包括控制部分和与控制部分连接的至少一个传送部分。 控制部分包括控制电路和电源模块。 控制电路用于确定与控制部分连接的发送部分的电力需求，并控制电源模块向发送部分发送满足电力要求的电气信号。 发射部分基于电信号产生磁场，并向接收机的负载供电。 无线供电装置和方法使得每个线圈能够产生具有期望功率的电磁感应，以便合理地为接收器供电，并且减少发射部分的数量和复杂性。