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    Systems and Methods for Effective Gap Filtering and Atmospheric Pressure RF Heating of Ions
    51.
    发明申请
    Systems and Methods for Effective Gap Filtering and Atmospheric Pressure RF Heating of Ions 审中-公开

    公开(公告)号：US20190113478A1

    公开(公告)日：2019-04-18

    申请号：US16088103

    申请日：2017-03-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Bradley B. Schneider ,  Erkinjon Nazarov ,  Thomas R. Covey

    IPC: G01N27/62 ,  H01J49/16

    Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.

    Jet injector inlet for a differential mobility spectrometer
    52.
    发明授权
    Jet injector inlet for a differential mobility spectrometer 有权

    公开(公告)号：US09835588B2

    公开(公告)日：2017-12-05

    申请号：US15107487

    申请日：2014-11-18

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： Thomas R. Covey ,  Bradley Schneider ,  Erkinjon Nazarov

    IPC: H01J49/04 ,  G01N27/62 ,  H01J49/00

    CPC classification number: G01N27/624 ,  H01J49/0031

    Abstract: A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.

    Magnetic Elements for Processing Fluids
    55.
    发明申请
    Magnetic Elements for Processing Fluids 审中-公开
    加工液磁性元件

    公开(公告)号：US20170074871A1

    公开(公告)日：2017-03-16

    申请号：US15121803

    申请日：2015-02-27

    Applicant: DH Technologies Development PTE Ltd.

    Inventor： John L. Campbell ,  Thomas R. Covey ,  Chang Liu ,  Subhasish Purkayastha

    IPC: G01N33/543 ,  B01F13/08 ,  B01F13/00 ,  B01L3/00 ,  G01N1/38

    CPC classification number: G01N33/54326 ,  B01F13/0059 ,  B01F13/0818 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/0647 ,  B01L2300/0819 ,  B01L2400/0427 ,  B01L2400/043 ,  G01N1/38 ,  G01N27/745 ,  G01N35/0098 ,  G01N2001/386

    Abstract: Methods and apparatus for processing fluids on a macro- or micro-scale are described. In various aspects, a fluid may have a plurality of elongated (i.e., substantially rod-shaped) magnetic elements disposed therein within a fluid container. An illustrative fluid container is an actuator electrode or a processing vial of a microfluidic device, such as a digital microfluidic device. A magnet component may be configured to generate a magnetic force sufficient to influence the movement of the plurality of elongated magnetic elements within the fluid to be processed. For example, the magnetic force (or magnetic force gradient) may influence the plurality of elongated magnetic elements to rotate, spin, and/or move laterally side-to-side. The shape and movements of the plurality of elongated magnetic elements facilitate the rapid and efficient processing of the fluid, such as fluid mixing and/or fluid separation.

    Abstract translation: 描述了在宏观或微观尺度上处理流体的方法和装置。 在各个方面，流体可以具有设置在流体容器内的多个细长（即基本棒状）的磁性元件。 说明性的流体容器是诸如数字微流体装置的微流体装置的致动器电极或处理小瓶。 磁体部件可以被配置为产生足以影响待处理流体中的多个细长磁性元件的运动的磁力。 例如，磁力（或磁力梯度）可以影响多个细长的磁性元件以使它们在侧面上相互旋转，旋转和/或横向移动。 多个细长磁性元件的形状和运动有助于流体的快速和有效的处理，例如流体混合和/或流体分离。

    Ion Mobility Method and Apparatus
    56.
    发明申请
    Ion Mobility Method and Apparatus 审中-公开
    离子流动性方法和装置

    公开(公告)号：US20160187296A1

    公开(公告)日：2016-06-30

    申请号：US14911582

    申请日：2014-08-14

    Applicant: Voislav BLAGOJEVIC ,  Diethard BOHME ,  DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Voislav Blagojevic ,  Diethard Bohme ,  Thomas R. Covey ,  Bradley B. Schneider

    IPC: G01N27/62

    CPC classification number: G01N27/624

    Abstract: A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers.

    Abstract translation: 一种用于进行离子迁移率分析的方法和系统，其将样品的组分电离成离子; 提供了场非对称波形离子迁移率或基于差分迁移率的离子迁移率滤波器，其包括至少两个电极，所述至少两个电极间隔开，使得在其间形成恒定尺寸的间隙，漂移气体通过该间隙流动; 将所述离子引入漂移气体中，其中所述漂移气体还包括液体改性剂的混合物。

    Contamination Filter for Mass Spectrometer
    57.
    发明申请
    Contamination Filter for Mass Spectrometer 有权
    质谱仪污染过滤器

    公开(公告)号：US20160118234A1

    公开(公告)日：2016-04-28

    申请号：US14894494

    申请日：2014-06-20

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Thomas R. Covey ,  Bradley B. Schneider

    IPC: H01J49/00 ,  G01N27/62

    CPC classification number: G01N27/624 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0422 ,  H01J49/145 ,  H01J49/165

    Abstract: Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss.

    Abstract translation: 本文提供了用于进行质谱分析的方法和系统。 根据申请人的教导的各个方面，所述方法和系统可以利用在大气压或低真空压力下操作的离子迁移谱仪来除去主要贡献者对位于一个或多个内部的质谱仪的关键下游组分的污染和降解 高真空系统（例如离子光学，质量过滤器，检测器），信号损失有限。

    BALL ASSISTED DEVICE FOR ANALYTICAL SURFACE SAMPLING
    58.
    发明申请
    BALL ASSISTED DEVICE FOR ANALYTICAL SURFACE SAMPLING 有权
    用于分析表面采样的球辅助装置

    公开(公告)号：US20140096624A1

    公开(公告)日：2014-04-10

    申请号：US13644941

    申请日：2012-10-04

    Applicant: UT-BATTELLE, LLC ,  DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： Mariam S. ElNaggar ,  Gary J. VAN BERKEL ,  Thomas R. Covey

    IPC: G01N1/14

    CPC classification number: G01N1/14 ,  G01N2001/028

    Abstract: A system for sampling a surface includes a sampling probe having a housing and a socket, and a rolling sampling sphere within the socket. The housing has a sampling fluid supply conduit and a sampling fluid exhaust conduit. The sampling fluid supply conduit supplies sampling fluid to the sampling sphere. The sampling fluid exhaust conduit has an inlet opening for receiving sampling fluid carried from the surface by the sampling sphere. A surface sampling probe and a method for sampling a surface are also disclosed.

    Abstract translation: 用于对表面进行采样的系统包括具有壳体和插座的采样探针以及插座内的滚动采样球。 壳体具有取样流体供应管道和采样流体排出管道。 采样流体供应管道将采样流体提供给采样球体。 取样流体排出管道具有入口开口，用于接收由取样球体从表面携带的取样流体。 还公开了表面采样探针和用于对表面进行取样的方法。

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