Apparatus and method for parallel collection and analysis of the proteome and complex compositions
    52.
    发明授权
    Apparatus and method for parallel collection and analysis of the proteome and complex compositions 有权
    用于平行收集和分析蛋白质组和复合组合物的装置和方法

    公开(公告)号:US09084994B2

    公开(公告)日:2015-07-21

    申请号:US13199811

    申请日:2011-09-09

    摘要: This invention relates to a kit and a method for the collection and analysis of complex protein mixtures. More particularly, the invention relates to a kit comprising a single barrel filtration well or a multi-well filtration plate wherein each well comprises an upper filtration zone; a lower filtration zone; a conical flow director zone; and, an elution tip, wherein the upper filtration zone and the lower filtration zone are separated by a retainer ring disposed within the lower filtration zone. The upper filtration zone comprises an upper collection zone, a sponge zone, and a deep bed filtration zone; and, the lower filtration zone comprises the retainer ring, a supported hydrophilic membrane and a lower bed filtration media. When used with an array of selected buffer solutions, the multi-well filtration plate can provide accurate, automated, high-throughput protein analysis by affinity chromatography.

    摘要翻译: 本发明涉及一种用于收集和分析复合蛋白质混合物的试剂盒和方法。 更具体地说,本发明涉及包括单筒过滤井或多孔过滤板的试剂盒,其中每个孔包括上部过滤区; 一个较低的过滤区; 圆锥形导流器区; 以及洗脱头,其中上过滤区和下过滤区被设置在下过滤区内的保持环分开。 上部过滤区域包括上部收集区域,海绵区域和深层过滤区域; 并且,下部过滤区域包括保持环,支撑的亲水膜和下层过滤介质。 当与所选择的缓冲溶液阵列一起使用时,多孔过滤板可以通过亲和层析提供准确,自动化,高通量的蛋白质分析。

    Tagatose production using simulated moving bed separation
    53.
    发明申请
    Tagatose production using simulated moving bed separation 有权
    使用模拟移动床分离的塔格斯生产

    公开(公告)号:US20130317210A1

    公开(公告)日:2013-11-28

    申请号:US13506889

    申请日:2012-05-22

    IPC分类号: C07H1/00

    摘要: Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.

    摘要翻译: 公开了一种在酸水解之后从乳糖生产d-塔格糖的方法,以提供具有1当量的D-葡萄糖和1当量的D-半乳糖的水解产物,用于每单位转化的乳糖。 更具体地,本发明涉及将D-半乳糖异构化为d-塔格糖的方法,以及使用基于模拟移动床(SMB)分离的简化分离方案。 D-半乳糖与D-塔格糖的异构化在氧化钙或氢氧化钙的存在下进行。 该方法可用于提供简单的处理途径以从乳糖水解产物中提供纯的d-塔格糖和葡萄糖作为两种产物。 在替代实施方案中,公开了用于从发酵乳糖水解产物生产d-塔格糖的方法,以提供结晶的d-塔格糖产品。 D-塔格糖可用作食品添加剂,甜味剂,增白剂,稳定剂,或作为保湿剂。

    Reaction process in hybrid reactor for propylene ammoxidation
    55.
    发明授权
    Reaction process in hybrid reactor for propylene ammoxidation 失效
    用于丙烯氨氧化的混合反应器中的反应过程

    公开(公告)号:US06649130B1

    公开(公告)日:2003-11-18

    申请号:US09635953

    申请日:2000-08-10

    IPC分类号: B01J808

    摘要: A hybrid reactor arrangement provides a reactive design that achieves higher acrylonitrile yield and lower catalyst circulating rate. The hybrid reactor design first passes a mixture of reactants and catalyst through a circulating bubbling bed reaction section. Heat exchange coils or other cooling medium in the bubbling bed reactor section maintain temperature in a range that will maximize the selectivity of reactants to the acrylonitrile product. The bubbling bed reactor section provides the initial conversion of the reactant. A circulating fluidized bed reaction zone finishes the conversion of reactants to a high yield under conditions that reduce the occurrence of secondary reactions that could otherwise produce unwanted by-products. The circulating fluidized bed reactor section maintains nearly plug flow conditions that allow continued conversion of unreacted feed components through primary reactions while limiting the time for secondary reactions to continue and diminish the final yield of products. Selectivity and conversion may also be improved by sequential addition of oxygen into the CFB reaction section. The sequential addition of oxygen may occur by the direct injection of an oxygen-containing gas or by the delivery of re-oxidized catalyst particles that are fully recharged with the lattice oxygen necessary for the reaction. Through this method the hybrid reactor provides the typical 5% improvement of higher acrylonitrile product yield from CFB-type reaction zones while reducing the required catalyst circulation by a factor of 10 or more.

    摘要翻译: 混合反应器装置提供了实现较高丙烯腈产率和较低催化剂循环速率的反应性设计。 混合反应器设计首先将反应物和催化剂的混合物通过循环鼓泡床反应段。 鼓泡床反应器部分中的热交换盘管或其它冷却介质将温度保持在使反应物对丙烯腈产物的选择性最大化的范围内。 起泡床反应器部分提供反应物的初始转化。 循环流化床反应区在减少可能产生不需要的副产物的次级反应的情况下,完成反应物转化为高收率。 循环流化床反应器部分保持几乎堵塞流动条件,其允许未反应的进料组分继续转化通过初级反应,同时限制二级反应的持续时间并降低产物的最终产率。 还可以通过将顺序加入到CFB反应部分中来提高选择性和转化率。 氧的顺序添加可以通过直接注入含氧气体或通过输送用反应所需的晶格氧充分再充电的再氧化的催化剂颗粒进行。 通过该方法,混合反应器提供了CFB型反应区中较高丙烯腈产物产率的典型的5%的改进,同时将需要的催化剂循环减少10倍或更多。

    Metal cation-modified alkylation catalysts
    56.
    发明授权
    Metal cation-modified alkylation catalysts 失效
    金属阳离子改性烷基化催化剂

    公开(公告)号:US5739074A

    公开(公告)日:1998-04-14

    申请号:US453044

    申请日:1995-05-30

    摘要: A catalytic composite of a refractory inorganic oxide whose bound surface hydroxyl group has reacted with a Friedel-Crafts type metal halide and whose acidity has been modified by the deposition of a monovalent metal cation, especially an alkali metal cation, or alkaline earth metal cation shows superior selectivity and a significantly decreased cracking tendency relative to similar catalysts without the monovalent metal or alkaline earth metal cation. The resulting alkylate from an isobutane-butene feedstock shows a substantial increase in research octane number relative to the alkylate formed by a similar catalyst which has not been so modified by an alkali or alkaline earth metal cation.

    摘要翻译: 结合表面羟基与Friedel-Crafts型金属卤化物反应并且酸性已经通过沉积一价金属阳离子,特别是碱金属阳离子或碱土金属阳离子而改性的耐火无机氧化物的催化复合物显示出 优异的选择性和相对于没有一价金属或碱土金属阳离子的类似催化剂显着降低的开裂趋势。 从异丁烷 - 丁烯原料得到的烷基化物相对于由未被碱金属或碱土金属阳离子改性的类似催化剂形成的烷基化物,研究辛烷值显着增加。

    Rotary valve for interconnecting conduits
    57.
    发明授权
    Rotary valve for interconnecting conduits 失效
    用于互连导管的旋转阀

    公开(公告)号:US4632149A

    公开(公告)日:1986-12-30

    申请号:US679858

    申请日:1984-12-10

    IPC分类号: F16K11/074

    摘要: A unitary multiport rotary disc valve capable of accomplishing the simultaneous interconnection of a plurality of conduits in accordance with a previously determined cycle, where any conduit communicates with no more than one other conduit at any one cycle step, or valve index position. The conduits to be interconnected are attached to the bottom of a discoid stationery body, or stator, having channels in it which communicate between the conduits and flow paths in a discoid rotating body, or rotor, which assumes various positions according to the cycle steps and distributes fluid flowing in the conduits in a different manner in each cycle step.

    摘要翻译: 能够根据预先确定的循环来实现多个导管的同时互连的单一多口旋转盘阀,其中任何管道以任何一个循环步骤或阀指示位置与不超过一个其它导管连通。 要互连的导管连接到圆盘状文具本体或定子的底部,圆盘状文具本体或定子具有通道,该通道在导管和圆盘形旋转体或转子之间连通,该旋转体或转子根据循环步骤呈现各种位置, 在每个循环步骤中以不同的方式分配在管道中流动的流体。

    Serial flow continuous separation process
    58.
    发明授权
    Serial flow continuous separation process 失效
    串流连续分离过程

    公开(公告)号:US4498991A

    公开(公告)日:1985-02-12

    申请号:US622031

    申请日:1984-06-18

    申请人: Anil R. Oroskar

    发明人: Anil R. Oroskar

    摘要: A process for separating an extract component from a raffinate component contained in a feed mixture. A unidirectional fluid flow system is maintained through a series of separating units through which the components travel at different rates. The units are interconnected in series so as to form a single closed loop. A component concentration distribution is established within the system of units so as to comprise a series of zones. Feed and displacement fluid are each mixed with a different intercolumn stream prior to being passed into the inlets of two of the units and extract and raffinate are taken only as portions of streams from outlets of two or more of the units at appropriate points on the component concentration distribution. At the appropriate times the inlets and outlets are shifted so as to simulate movement of the units in a direction downstream with respect to the direction of fluid flow and thereby enable the inlets and outlets to continually lie in the appropriate zones.

    摘要翻译: 一种从提取物组分与进料混合物中所含的萃余液组分分离的方法。 通过一系列分离单元来维持单向流体流动系统,组件通过这些分离单元以不同的速率行进。 这些单元串联连接以形成单个闭合回路。 在单元系统内建立组分浓度分布,以便包括一系列区域。 进料和置换流体在进入两个单元的入口之前各自与不同的串间流混合,并且萃取物和萃余液仅作为部件上的两个或更多个单元的出口的部分流入部件上的适当点 浓度分布。 在适当的时候,入口和出口被移动,以模拟单元在相对于流体流动方向的下游方向上的运动,从而使入口和出口能够连续地位于适当的区域中。