公开(公告)号：US20130317210A1

公开(公告)日：2013-11-28

申请号：US13506889

申请日：2012-05-22

申请人： Anil R. Oroskar ,  Omkar M. Kulkami ,  David W. House ,  Deepak Sharma ,  Rakesh Vikraman Nair Rema

发明人： Anil R. Oroskar ,  Omkar M. Kulkami ,  David W. House ,  Deepak Sharma ,  Rakesh Vikraman Nair Rema

IPC分类号： C07H1/00

CPC分类号： C13K13/00 ,  B01D15/185 ,  B01D15/365 ,  B01J39/05 ,  B01J39/26 ,  B01J47/022 ,  C13K1/00

摘要： Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.

摘要翻译： 公开了一种在酸水解之后从乳糖生产d-塔格糖的方法，以提供具有1当量的D-葡萄糖和1当量的D-半乳糖的水解产物，用于每单位转化的乳糖。 更具体地，本发明涉及将D-半乳糖异构化为d-塔格糖的方法，以及使用基于模拟移动床（SMB）分离的简化分离方案。 D-半乳糖与D-塔格糖的异构化在氧化钙或氢氧化钙的存在下进行。 该方法可用于提供简单的处理途径以从乳糖水解产物中提供纯的d-塔格糖和葡萄糖作为两种产物。 在替代实施方案中，公开了用于从发酵乳糖水解产物生产d-塔格糖的方法，以提供结晶的d-塔格糖产品。 D-塔格糖可用作食品添加剂，甜味剂，增白剂，稳定剂，或作为保湿剂。

公开(公告)号：US08802843B2

公开(公告)日：2014-08-12

申请号：US13506889

申请日：2012-05-22

申请人： Anil R. Oroskar ,  Omkar M. Kulkarni ,  David W. House ,  Deepak Sharma ,  Rakesh Vikraman Nair Rema

发明人： Anil R. Oroskar ,  Omkar M. Kulkarni ,  David W. House ,  Deepak Sharma ,  Rakesh Vikraman Nair Rema

IPC分类号： C07H1/06 ,  C07H1/08

CPC分类号： C13K13/00 ,  B01D15/185 ,  B01D15/365 ,  B01J39/05 ,  B01J39/26 ,  B01J47/022 ,  C13K1/00

摘要： Disclosed is a process for the production of d-tagatose from lactose after acid hydrolysis to provide a hydrolysate having 1 equiv of d-glucose and 1 equiv of d-galactose for each unit of lactose converted. More particularly, the invention relates to a process for the isomerization of d-galactose to d-tagatose and the use of a simplified separation scheme based on simulated moving bed (SMB) separation. The isomerization of d-galactose to d-tagatose is carried out in the presence of calcium oxide or calcium hydroxide. The process is useful for providing a simplified processing route to providing pure d-tagatose and glucose as two products from lactose hydrolysate. In an alternate embodiment, a process is disclosed for the production of d-tagatose from fermented lactose hydrolysate to provide a crystallized d-tagatose product. D-tagatose is useful as a food additive, as a sweetener, as a texturizer, as a stabilizer, or as a humectant.

摘要翻译： 公开了一种在酸水解之后从乳糖生产d-塔格糖的方法，以提供具有1当量的D-葡萄糖和1当量的D-半乳糖的水解产物，用于每单位转化的乳糖。 更具体地，本发明涉及将D-半乳糖异构化为d-塔格糖的方法，以及使用基于模拟移动床（SMB）分离的简化分离方案。 D-半乳糖与D-塔格糖的异构化在氧化钙或氢氧化钙的存在下进行。 该方法可用于提供简单的处理途径以从乳糖水解产物中提供纯的d-塔格糖和葡萄糖作为两种产物。 在替代实施方案中，公开了用于从发酵乳糖水解产物生产d-塔格糖的方法，以提供结晶的d-塔格糖产品。 D-塔格糖可用作食品添加剂，甜味剂，增白剂，稳定剂，或作为保湿剂。

公开(公告)号：US08658845B2

公开(公告)日：2014-02-25

申请号：US13478160

申请日：2012-05-23

申请人： Anil R. Oroskar ,  Deepak Sharma ,  David W. House ,  Alice M. Havill

发明人： Anil R. Oroskar ,  Deepak Sharma ,  David W. House ,  Alice M. Havill

IPC分类号： C07C29/76

CPC分类号： C07C29/76 ,  C07C29/80 ,  Y02E50/17 ,  Y02E50/343 ,  C07C31/08 ,  C07C31/207

摘要： Disclosed is a process and an adsorbent for the separation of ethanol associated oxygenates from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. After pretreatment, the separation is carried out in a simulated moving bed adsorption system employing an stationary phase adsorbent comprising fluorinated carbon or modified C18 silica gel selective for the adsorption of ethanol and associated oxygenates, such as 2,3-butanediol, with a mobile phase desorbent selected from the group consisting of methanol, ethanol, propanol, and methyl tertiary butyl ether. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods.

摘要翻译： 公开了一种用于在衍生自生物发酵过程的有机化合物存在下从乙醇和相关含氧化合物的稀释混合物中分离乙醇相关氧化物的方法和吸附剂。 在预处理之后，在模拟移动床吸附系统中进行分离，所述吸附系统使用包含氟化碳的固定相吸附剂或选择性地用于吸附乙醇和相关氧化物如2,3-丁二醇的改性C18硅胶与流动相 选自甲醇，乙醇，丙醇和甲基叔丁基醚的解吸剂。 该方法可用于从含水稀释浓度的乙醇的有机化合物的稀释含水混合物中除去水，并通过发酵，生物提取，生物催化和酶法，通过常规蒸馏方法经济可回收而产生。

公开(公告)号：US20130317260A1

公开(公告)日：2013-11-28

申请号：US13478160

申请日：2012-05-23

申请人： Anil R. Oroskar ,  Deepak Sharma ,  David W. House ,  Alice M. Havill

发明人： Anil R. Oroskar ,  Deepak Sharma ,  David W. House ,  Alice M. Havill

IPC分类号： C07C29/76

CPC分类号： C07C29/76 ,  C07C29/80 ,  Y02E50/17 ,  Y02E50/343 ,  C07C31/08 ,  C07C31/207

摘要： Disclosed is a process and an adsorbent for the separation of ethanol associated oxygenates from a dilute mixture of ethanol and associated oxygenates in water in the presence of organic compounds derived from a biofermentation process. After pretreatment, the separation is carried out in a simulated moving bed adsorption system employing an stationary phase adsorbent comprising fluorinated carbon or modified C18 silica gel selective for the adsorption of ethanol and associated oxygenates, such as 2,3-butanediol, with a mobile phase desorbent selected from the group consisting of methanol, ethanol, propanol, and methyl tertiary butyl ether. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods.

摘要翻译： 公开了一种用于在衍生自生物发酵过程的有机化合物存在下从乙醇和相关含氧化合物的稀释混合物中分离乙醇相关氧化物的方法和吸附剂。 在预处理之后，在模拟移动床吸附系统中进行分离，所述吸附系统使用包含氟化碳的固定相吸附剂或选择性地用于吸附乙醇和相关氧化物如2,3-丁二醇的改性C18硅胶与流动相 选自甲醇，乙醇，丙醇和甲基叔丁基醚的解吸剂。 该方法可用于从含水稀释浓度的乙醇的有机化合物的稀释含水混合物中除去水，并通过发酵，生物提取，生物催化和酶法，通过常规蒸馏方法经济可回收而产生。

公开(公告)号：US06340432B1

公开(公告)日：2002-01-22

申请号：US09537537

申请日：2000-03-29

申请人： David W. House

发明人： David W. House

IPC分类号： B01D1508

CPC分类号： B01J20/3204 ,  B01D15/1821 ,  B01D15/3833 ,  B01J20/286 ,  B01J20/289 ,  B01J20/29 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3261 ,  B01J20/3263

摘要： A chromatographic process for separating racemic mixtures using a set of chiral stationary phases based on yohimbine and its derivatives has been developed. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a urethane linkage to a polymethylenesilyl chain attached to the bound hydroxyl groups of a refractory inorganic oxide by Si—O bonds. The resulting chiral stationary phases have multiple chiral recognition sites and can be used with a broad spectrum of materials as eluents without leaching.

摘要翻译： 已经开发了使用基于育亨宾及其衍生物的一组手性固定相分离外消旋混合物的层析方法。 特别地，育亨宾及其类似物的羟基官能团通过氨基甲酸酯键与通过Si-O键连接到耐火无机氧化物的结合羟基的聚亚甲基硅烷基链共价键合。 所得到的手性固定相具有多个手性识别位点，并可与广谱的材料一起使用，作为不浸出的洗脱液。

公开(公告)号：US5858910A

公开(公告)日：1999-01-12

申请号：US977598

申请日：1997-11-25

申请人： David W. House

发明人： David W. House

IPC分类号： B01D15/18 ,  B01D15/38 ,  B01J20/32 ,  B01J20/10 ,  B01D39/16 ,  B01J20/22

CPC分类号： B01J20/3204 ,  B01D15/3833 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3244 ,  B01J20/3261 ,  B01J20/3263 ,  B01D15/1821

摘要： A set of chiral stationary phases is based on yohimbine and its derivatives. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a urethane linkage to a polymethylenesilyl chain attached to the bound hydroxyl groups of a refractory inorganic oxide by Si-O bonds. The resulting chiral stationary phases have multiple chiral recognition sites and can be used with a broad spectrum of materials as eluents without leaching.

摘要翻译： 一组手性固定相是基于育亨宾及其衍生物。 特别地，育亨宾及其类似物的羟基官能团通过氨基甲酸酯键与通过Si-O键连接到耐火无机氧化物的结合羟基的聚亚甲基硅烷基链共价键合。 所得到的手性固定相具有多个手性识别位点，并可与广谱的材料一起使用，作为不浸出的洗脱液。

公开(公告)号：US5166185A

公开(公告)日：1992-11-24

申请号：US533981

申请日：1990-06-06

申请人： David W. House ,  Ray V. Scott, Jr. ,  Mark J. Gattuso

发明人： David W. House ,  Ray V. Scott, Jr. ,  Mark J. Gattuso

IPC分类号： C08G18/32 ,  C08G18/66

CPC分类号： C08G18/6685 ,  C08G18/3243 ,  C08G2101/0008 ,  C08G2101/005 ,  C08G2101/0083

摘要： N,N'-di-sec-alkenyl-or-di-sec-alkyl-substituted methylene diphenyl diamines are effective curing agents for making polyurethane foams from MDI-based polyisocyanates. The diamines are especially advantageous since foams of lower density having lower hardness can be obtained without utilizing chlorofluorocarbous (CFC's) and without sacrificing tensile strength, tear strength, SAG or compression set values.

摘要翻译： N，N'-二仲链烯基或二仲烷基取代的亚甲基二苯基二胺是用于制备基于MDI的多异氰酸酯的聚氨酯泡沫的有效固化剂。 二胺是特别有利的，因为可以在不使用氯氟碳（CFC））的情况下获得具有较低硬度的较低密度的泡沫，并且不牺牲拉伸强度，撕裂强度，SAG或压缩永久变形值。

公开(公告)号：US4806616A

公开(公告)日：1989-02-21

申请号：US130838

申请日：1987-12-09

申请人： William M. Baumann ,  Ray V. Scott, Jr. ,  David W. House ,  Dusan J. Engel

发明人： William M. Baumann ,  Ray V. Scott, Jr. ,  David W. House ,  Dusan J. Engel

IPC分类号： C08G18/32 ,  C08G18/65 ,  C08G18/30 ,  C08G18/34

CPC分类号： C08G18/6529 ,  C08G18/325 ,  C08G2120/00

摘要： N,N'-dialkyl- and diaylphenylenediamines are effective curing agents in combination with other polyamines and polyols in reaction injection molding for a diverse class of polyisocyanates. The diamines provide a broad spectrum of cure times, as well as giving elastomers an interesting and useful diversity of properties. Such polyamines may be used as a constituent in a blend of polyamines as the isocyanate-reactive component, in which case the elastomer may be viewed as predominantly a polyurea, or as a constituent in a blend with polyols, in which case the elastomer may be viewed as an elastomer with both urethane and urea segments.

摘要翻译： N，N'-二烷基和二亚苯基二胺是在多种多异氰酸酯的反应注射成型中与其它多胺和多元醇组合的有效固化剂。 二胺提供广泛的固化时间，以及赋予弹性体一种有趣和有用的多样性。 这种多胺可以作为多胺的混合物中的组分用作异氰酸酯反应性组分，在这种情况下，弹性体可以主要看作聚脲，或作为与多元醇的共混物中的组分，在这种情况下，弹性体可以是 被视为具有氨基甲酸酯和尿素段的弹性体。

公开(公告)号：US4459186A

公开(公告)日：1984-07-10

申请号：US412403

申请日：1982-08-27

申请人： Thomas P. Malloy ,  Mark A. Halter ,  David W. House

发明人： Thomas P. Malloy ,  Mark A. Halter ,  David W. House

IPC分类号： C25B3/02

CPC分类号： C25B3/02

摘要： Aromatic ketones may be prepared by subjecting an alkyl aromatic compound containing more than one carbon atom in the alkyl substituent to an electrical energy which includes a direct electrical current in the presence of a nucleophile such as an organometallic oxide, a solvent and a reaction initiator such as an alkali metal hydroxide and a quaternary ammonium hydroxide to produce a ketal, following which the ketal may be converted to the desired ketone by hydrolysis.

摘要翻译： 芳族酮可以通过使烷基取代基中含有多于一个碳原子的烷基芳族化合物在亲核试剂如有机金属氧化物，溶剂和反应引发剂等存在下包含直接电流来进行制备 作为碱金属氢氧化物和季铵氢氧化物以产生缩酮，随后可以通过水解将缩酮转化为所需的酮。

公开(公告)号：US4418225A

公开(公告)日：1983-11-29

申请号：US338443

申请日：1982-01-08

申请人： David W. House

发明人： David W. House

IPC分类号： C07C29/09 ,  C07C35/12

CPC分类号： C07C35/12 ,  C07C29/095 ,  C07B2200/07 ,  C07C2101/14

摘要： 1-Menthol can be readily obtained from racemic menthol by conversion of the latter to the diastereomeric esters of an optically active amino acid and chromatographing the diastereomers. The separation of the diastereomeric esters is relatively insensitive to the support or to the solvent used as eluant, and satisfactory separation occurs under a broad variety of conditions. 1-Menthol can be obtained by base catalyzed hydrolysis of the purified diastereomer with high optical purity.

摘要翻译： 1-薄荷醇可以通过将后者转化成光学活性氨基酸的非对映体酯并色谱分离非对映异构体，从外消旋薄荷醇中容易地得到。 非对映体酯的分离对于载体或用作洗脱剂的溶剂相对不敏感，并且在各种条件下发生令人满意的分离。 1-薄荷醇可以通过具有高光学纯度的纯化非对映异构体的碱催化水解获得。