公开(公告)号：US06270952B1

公开(公告)日：2001-08-07

申请号：US09110776

申请日：1998-07-06

Applicant: David Cook ,  Adonis Stassinopoulos

Inventor： David Cook ,  Adonis Stassinopoulos

IPC: A01N102

CPC classification number: A61L2/0088

Abstract: Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. Biological materials which may be treated include whole blood, red blood cells, blood plasma, and platelets. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.

Abstract translation: 提供了用于猝灭病原体灭活化合物在生物材料中的不希望的副反应的方法。 在一个具体实施方案中，提供了用于猝灭病原体灭活化合物的不希望的副反应的方法，其包括可亲电子基团或能够形成亲电基团的官能团。 在该实施方案中，用病原体灭活化合物和猝灭剂处理材料，其中猝灭剂包含能够与亲电子基团共价反应的亲核官能团。 病原体灭活化合物上的亲电基团优选为非自由基阳离子基团。 在一个实施方案中，病原体灭活化合物包括核酸结合配体和芥子基团，其中芥末基团能够在原位反应形成亲电子基团。 优选的猝灭剂是硫醇，如谷胱甘肽。 可以治疗的生物材料包括全血，红细胞，血浆和血小板。 该方法允许在病原体灭活期间抑制含红细胞的材料中的红细胞的修饰。

公开(公告)号：US6143490A

公开(公告)日：2000-11-07

申请号：US476842

申请日：1995-06-07

Applicant: David Cook ,  Susan Wollowitz ,  Aileen Nerio

Inventor： David Cook ,  Susan Wollowitz ,  Aileen Nerio

IPC: C12Q1/00 ,  A61K31/47 ,  A61K31/473 ,  A61K35/16 ,  A61L2/00 ,  A61P31/12 ,  C07D219/12 ,  C07D219/14 ,  C07D493/04 ,  C12N1/20 ,  C12N5/06 ,  C12N5/08 ,  C12N7/04 ,  C12N7/06 ,  C12Q1/68 ,  A01N1/02

CPC classification number: C07D493/04 ,  A61L2/0088 ,  C07D219/12 ,  C12N7/00 ,  C12N2730/10163 ,  C12N2740/16063 ,  C12N2795/18163

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

公开(公告)号：US6093725A

公开(公告)日：2000-07-25

申请号：US3115

申请日：1998-01-06

Applicant: David Cook ,  John E. Merritt ,  Aileen Nerio ,  Henry Rapoport ,  Adonis Stassinopoulos ,  Susan Wollowitz ,  Jan Matejovic

Inventor： David Cook ,  John E. Merritt ,  Aileen Nerio ,  Henry Rapoport ,  Adonis Stassinopoulos ,  Susan Wollowitz ,  Jan Matejovic

IPC: A61L2/00 ,  A61M1/02 ,  B01J20/28 ,  C07D219/10 ,  C07D405/12 ,  C07D493/04 ,  C07F9/64 ,  A61K31/44 ,  C07D219/08

CPC classification number: C07D405/12 ,  A61L2/0082 ,  A61L2/0088 ,  A61M1/0209 ,  B01J20/28 ,  C07D219/10 ,  C07D493/04 ,  C07F9/64

Abstract: Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.

公开(公告)号：US12270286B2

公开(公告)日：2025-04-08

申请号：US18436806

申请日：2024-02-08

Applicant: David Cook

Inventor： David Cook

IPC: E21B43/26 ,  G06F30/27 ,  G01V1/40

Abstract: An apparatus and method for fracking optimization, wherein the apparatus includes at least a processor, and a memory, wherein the memory containing instructions configuring the at least a processor to receive a reservoir datum from at least a sensing device, generate a production training data include a plurality of reservoir datums as input correlated to a plurality of optimal production parameters as output, train a fracking optimization machine-learning model using the production training data, determine an optimal production parameter as a function of the fracking optimization machine-learning model, and generating an optimal production plan as a function of the optimal production parameter.

公开(公告)号：US20250111225A1

公开(公告)日：2025-04-03

申请号：US18737091

申请日：2024-06-07

Applicant: David Cook

Inventor： David Cook

IPC: G06N3/08

Abstract: An apparatus and method for generating a compiled artificial intelligence (AI) model. The apparatus incudes a processor that is configured to receive data sets from user devices. The processor is further configured to convert the data sets using a machine-learning model into a cleansed data format and generate an accumulated model using the converted data sets as training data.

公开(公告)号：US12159091B2

公开(公告)日：2024-12-03

申请号：US18405465

申请日：2024-01-05

Applicant: David Cook

Inventor： David Cook

IPC: G06F30/28

Abstract: An apparatus for multi-stage fracking, wherein the apparatus includes a pump configured to pump a fracking fluid into a rock region comprises a plurality of rock zones, and a computing device communicatively connected to the pump, wherein the computing device includes at least a processor, and a memory communicatively connected to the at least a processor containing instructions configuring the at least a processor to receive reservoir data, determine an optimal fracking stimulation parameter as a function of the reservoir data, identify a fracking stage as a function of the optimal fracking stimulation parameter, and adjust a pump configuration of the pump as a function of the fracking stage.

公开(公告)号：US20240005145A1

公开(公告)日：2024-01-04

申请号：US17853143

申请日：2022-06-29

Applicant: David Cook

Inventor： David Cook

IPC: G06N3/08

CPC classification number: G06N3/08

Abstract: An apparatus and method for generating a compiled artificial intelligence (AI) model. The apparatus incudes a processor that is configured to receive data sets from user devices. The processor is further configured to convert the data sets using a machine-learning model into a cleansed data format and generate an accumulated model using the converted data sets as training data.

公开(公告)号：US09878725B2

公开(公告)日：2018-01-30

申请号：US14853997

申请日：2015-09-14

Applicant: David Cook

Inventor： David Cook

IPC: F17C13/08 ,  B61C17/02

CPC classification number: B61C17/00 ,  F17C13/08 ,  F17C2201/0109 ,  F17C2201/035 ,  F17C2201/054 ,  F17C2201/056 ,  F17C2203/0391 ,  F17C2203/0619 ,  F17C2203/0629 ,  F17C2203/0663 ,  F17C2205/0107 ,  F17C2205/0111 ,  F17C2205/0134 ,  F17C2205/0188 ,  F17C2205/0192 ,  F17C2221/012 ,  F17C2221/033 ,  F17C2223/0123 ,  F17C2223/0161 ,  F17C2223/036 ,  F17C2227/0135 ,  F17C2270/0173 ,  Y02E60/321

Abstract: An enclosure for containing cylinders includes an upper surface, a lower surface, opposing side walls spanning the upper and lower surfaces, and an end surface spanning the upper and lower surfaces, the upper surface, lower surface, side walls, and end surface defining an enclosed space. A plurality of inner walls divides the enclosed space to define bays. A removable door panel is opposite the end surface and includes dividers defining portions of the door panel corresponding to the bays. The enclosure includes a plurality of first contact pads, a plurality of first mounting plates, a plurality of second contact pads, and a plurality of second mounting plates. At least one first contact pad and at least one second contact pad is positioned in a corner of each bay and each portion, respectively, at an angle that is neither parallel or perpendicular to either the side walls or the upper surface.

公开(公告)号：US20160068170A1

公开(公告)日：2016-03-10

申请号：US14853997

申请日：2015-09-14

Applicant: David Cook

Inventor： David Cook

IPC: B61C17/02

CPC classification number: B61C17/00 ,  F17C13/08 ,  F17C2201/0109 ,  F17C2201/035 ,  F17C2201/054 ,  F17C2201/056 ,  F17C2203/0391 ,  F17C2203/0619 ,  F17C2203/0629 ,  F17C2203/0663 ,  F17C2205/0107 ,  F17C2205/0111 ,  F17C2205/0134 ,  F17C2205/0188 ,  F17C2205/0192 ,  F17C2221/012 ,  F17C2221/033 ,  F17C2223/0123 ,  F17C2223/0161 ,  F17C2223/036 ,  F17C2227/0135 ,  F17C2270/0173 ,  Y02E60/321

Abstract: An enclosure for containing cylinders includes an upper surface, a lower surface, opposing side walls spanning the upper and lower surfaces, and an end surface spanning the upper and lower surfaces, the upper surface, lower surface, side walls, and end surface defining an enclosed space. A plurality of inner walls divides the enclosed space to define bays. A removable door panel is opposite the end surface and includes dividers defining portions of the door panel corresponding to the bays. The enclosure includes a plurality of first contact pads, a plurality of first mounting plates, a plurality of second contact pads, and a plurality of second mounting plates. At least one first contact pad and at least one second contact pad is positioned in a corner of each bay and each portion, respectively, at an angle that is neither parallel or perpendicular to either the side walls or the upper surface.

Abstract translation: 用于容纳圆柱体的外壳包括上表面，下表面，横跨上表面和下表面的相对侧壁，以及横跨上表面和下表面的端表面，上表面，下表面，侧壁和端表面， 密闭空间。 多个内壁分隔封闭空间以限定托架。 可拆卸的门板与端表面相对，并且包括限定门板对应于该间隔部分的分隔件。 外壳包括多个第一接触焊盘，多个第一安装板，多个第二接触焊盘和多个第二安装板。 至少一个第一接触垫和至少一个第二接触垫分别以不同于或垂直于侧壁或上表面的角度分别定位在每个隔间和每个部分的角部中。

公开(公告)号：US08935989B2

公开(公告)日：2015-01-20

申请号：US13077430

申请日：2011-03-31

Applicant: David Cook

Inventor： David Cook

IPC: G01D13/22

CPC classification number: G01D13/265 ,  G01D11/28

Abstract: A gauge assembly defining an interior direction and an exterior direction includes a gauge faceplate having a plurality of indicators and a hub that is substantially opaque. The hub includes a hub reflective portion that generally faces toward the interior direction. The assembly additionally includes a pointer having a first portion adjacent the hub and a second portion spaced away from the hub. The pointer is operable to move relative to the gauge faceplate such that the second portion distinguishes between the plurality of indicators. The pointer is substantially opaque, and the second portion includes a pointer reflective portion that generally faces toward the exterior direction. Moreover, the assembly includes a light source that emits a light generally in the exterior direction. The light reflects from the hub reflective portion generally toward the pointer reflective portion. The light also reflects from the pointer reflective portion generally toward the exterior direction.

Abstract translation: 限定内部方向和外部方向的量规组件包括具有多个指示器的计量面板和基本上不透明的毂。 轮毂包括大致面向内部方向的轮毂反射部分。 组件还包括指示器，其具有邻近轮毂的第一部分和与轮毂间隔开的第二部分。 指针可操作以相对于量规面板移动，使得第二部分区分多个指示器。 指针基本上是不透明的，并且第二部分包括大致朝向外部方向的指针反射部分。 此外，组件包括一般在外部方向发射光的光源。 光从轮毂反射部分大致朝向指示体反射部分反射。 光也通常指向外部方向从指示体反射部分反射。