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公开(公告)号:US20100169259A1
公开(公告)日:2010-07-01
申请号:US12387151
申请日:2009-04-28
申请人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号: G06N5/02
CPC分类号: A61B5/0484 , A61B5/01 , A61B5/02 , A61B5/024 , A61B5/11 , A61B5/145 , A61B5/14532 , A61B5/165 , A61B5/411 , A61B5/4833 , A61B5/4839 , A61B5/486 , A61B5/6822 , A61M11/00 , A61M15/00 , A61M15/0028 , A61M15/0065 , A61M15/009 , A61M15/02 , A61M15/08 , A61M2021/0016 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588 , A61M2209/088 , A61M2230/201 , A61M2230/205 , A63F2300/65 , A63F2300/6692 , G06F19/3462
摘要: Methods, computer program products, and systems are described that include accepting an indication of an individual's compliance with an artificial sensory experience and presenting an indication of an inhalation device-dispensed bioactive agent at least partially based on the indication of the individual's compliance with the artificial sensory experience.
摘要翻译: 描述了方法,计算机程序产品和系统,其包括接受个人对人造感觉经验的遵守的指示,并且至少部分地基于个体对人造物的符合性的指示来呈现吸入装置分配的生物活性剂的指示 感官体验。
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公开(公告)号:US20100163038A1
公开(公告)日:2010-07-01
申请号:US12387321
申请日:2009-04-30
申请人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号: A61M16/10
CPC分类号: A61B5/0484 , A61B5/01 , A61B5/02 , A61B5/024 , A61B5/11 , A61B5/145 , A61B5/14532 , A61B5/165 , A61B5/411 , A61B5/4833 , A61B5/4839 , A61B5/486 , A61B5/6822 , A61M11/00 , A61M15/00 , A61M15/0028 , A61M15/0065 , A61M15/009 , A61M15/02 , A61M15/08 , A61M2021/0016 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588 , A61M2209/088 , A61M2230/201 , A61M2230/205 , A63F2300/65 , A63F2300/6692 , G06F19/3462
摘要: Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of an inhalation device-dispensed bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the inhalation device-dispensed bioactive agent to the individual.
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公开(公告)号:US20100163037A1
公开(公告)日:2010-07-01
申请号:US12384203
申请日:2009-04-01
申请人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号: A61M15/00
CPC分类号: A61B5/0484 , A61B5/01 , A61B5/02 , A61B5/024 , A61B5/11 , A61B5/145 , A61B5/14532 , A61B5/165 , A61B5/411 , A61B5/4833 , A61B5/4839 , A61B5/486 , A61B5/6822 , A61M11/00 , A61M15/00 , A61M15/0028 , A61M15/0065 , A61M15/009 , A61M15/02 , A61M15/08 , A61M2021/0016 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588 , A61M2209/088 , A61M2230/201 , A61M2230/205 , A63F2300/65 , A63F2300/6692 , G06F19/00 , G06F19/3462
摘要: Methods, computer program products, and systems are described that include measuring at least one effect of an inhalation device-dispensed bioactive agent and artificial sensory experience on an individual and modifying at least one of the inhalation device-dispensed bioactive agent or the artificial sensory experience at least partially based on the at least one effect.
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公开(公告)号:US20100163026A1
公开(公告)日:2010-07-01
申请号:US12378485
申请日:2009-02-13
申请人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
发明人: Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Robert W. Lord , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR.
IPC分类号: A61M16/10
CPC分类号: A61B5/0484 , A61B5/01 , A61B5/02 , A61B5/024 , A61B5/11 , A61B5/145 , A61B5/14532 , A61B5/165 , A61B5/411 , A61B5/4833 , A61B5/4839 , A61B5/486 , A61B5/6822 , A61M11/00 , A61M15/00 , A61M15/0028 , A61M15/0065 , A61M15/009 , A61M15/02 , A61M15/08 , A61M2021/0016 , A61M2205/3553 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588 , A61M2209/088 , A61M2230/201 , A61M2230/205 , A63F2300/65 , A63F2300/6692 , G06F19/00 , G06F19/3462
摘要: Methods, computer program products, and systems are described that include accepting an indication of at least one health-related condition and presenting an indication of at least one artificial sensory experience and an indication of at least one inhalation therapy at least partially based on the accepting at least one indication of a health-related condition.
摘要翻译: 描述了方法,计算机程序产品和系统,其包括接受至少一个健康相关状况的指示,并且至少部分地基于接受的方式呈现至少一种人造感觉体验和至少一种吸入治疗的指示 至少有一个与健康有关的状况的指示。
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公开(公告)号:US20100129439A1
公开(公告)日:2010-05-27
申请号:US12428395
申请日:2009-04-22
申请人: Frank Alexis , Jinjun Shi , Matteo Iannacone , Ashley Moseman , Pamela Basto , Robert Langer , Omid C. Farokhzad , Ulrich von Andrian
发明人: Frank Alexis , Jinjun Shi , Matteo Iannacone , Ashley Moseman , Pamela Basto , Robert Langer , Omid C. Farokhzad , Ulrich von Andrian
CPC分类号: A61K9/14 , A61K38/20 , A61K38/21 , A61K39/00 , A61K39/0002 , A61K39/002 , A61K39/05 , A61K39/08 , A61K39/12 , A61K39/39 , A61K45/06
摘要: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
摘要翻译: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含免疫表面和免疫刺激部分的纳米载体。 在一些实施方案中,免疫刺激部分是佐剂。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计,制造和使用本发明的纳米载体及其药物组合物的方法。
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公开(公告)号:US07722894B2
公开(公告)日:2010-05-25
申请号:US10277562
申请日:2002-10-21
申请人: Yadong Wang , Guillermo Ameer , Robert Langer
发明人: Yadong Wang , Guillermo Ameer , Robert Langer
IPC分类号: A61F13/00
CPC分类号: C08G63/12
摘要: A biodegradable polymer comprising a condensation polymer of glycerol and a diacid. The polymer may be adapted for use as a tissue engineering construct. For example, it may be seeded with cells or molecules may be attached to it to modify the metabolism and proliferation of cells or to modify the degradation rate and/or mechanism of the polymer. The polymer may also be exploited in a variety of medical and non-medical applications.
摘要翻译: 包含甘油和二酸的缩聚物的可生物降解的聚合物。 聚合物可适用于组织工程构造。 例如,可以用细胞接种细胞或分子可以连接到细胞上以修饰细胞的代谢和增殖或改变聚合物的降解速率和/或机制。 聚合物也可以用于各种医疗和非医疗应用。
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公开(公告)号:US07718418B2
公开(公告)日:2010-05-18
申请号:US11799425
申请日:2007-04-30
申请人: W. Daniel Hillis , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Nathan P. Myhrvold , Lowell L. Wood, Jr.
发明人: W. Daniel Hillis , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Nathan P. Myhrvold , Lowell L. Wood, Jr.
CPC分类号: C12Q1/6879 , G06F19/18
摘要: Systems, methods, compositions and apparatus relating to genome selection are disclosed.
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公开(公告)号:US07713728B2
公开(公告)日:2010-05-11
申请号:US11799424
申请日:2007-04-30
申请人: W. Daniel Hillis , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Nathan P. Myhrvold , Lowell L. Wood, Jr.
发明人: W. Daniel Hillis , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Nathan P. Myhrvold , Lowell L. Wood, Jr.
CPC分类号: C12Q1/6879
摘要: Systems, methods, compositions and apparatus relating to genome selection are disclosed.
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公开(公告)号:US20100092425A1
公开(公告)日:2010-04-15
申请号:US12428388
申请日:2009-04-22
申请人: Ulrich von Andrian , Omid Farokhzad , Frank Alexis , Matteo Iannacone , Pamela Basto , Jinjun Shi , Ashley Moseman , Robert Langer
发明人: Ulrich von Andrian , Omid Farokhzad , Frank Alexis , Matteo Iannacone , Pamela Basto , Jinjun Shi , Ashley Moseman , Robert Langer
IPC分类号: A61K31/465 , A61K38/20 , A61K38/21 , A61P25/00
CPC分类号: A61K39/00
摘要: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
摘要翻译: 本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。 本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。 本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。 本发明提供包含本发明纳米载体的药物组合物。 本发明提供了设计,制造和使用本发明的纳米载体及其药物组合物的方法。 例如,本发明能够引发免疫应答的纳米载体和抗尼古丁抗体的产生。
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公开(公告)号:US20090137866A1
公开(公告)日:2009-05-28
申请号:US11998438
申请日:2007-11-28
申请人: Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: A61B1/00
CPC分类号: A61B5/4839 , A61B1/00016 , A61B1/00147 , A61B1/041 , A61B5/01 , A61B5/036 , A61B5/073 , A61B5/076 , A61B5/14539 , A61B5/42 , A61B7/008 , A61M31/002
摘要: Systems and methods are described for implementing or deploying medical or veterinary utility modules (a) operable for mooring at least partly within a digestive tract, (b) small enough to pass through the tract per vias naturales and including a wireless-control component, (c) having one or more attachment protrusions positionable adjacent to a mucous membrane, (d) configured to facilitate redundant modes of attachment, (e) facilitating a “primary” material supply deployable within a stomach for an extended and/or controllable period, (f) moored by one or more adaptable extender modules supported by a subject's head or neck, and/or (g) configured to facilitate supporting at least a sensor within a subject's body lumen for up to a day or more.
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