公开(公告)号：US20240156446A1

公开(公告)日：2024-05-16

申请号：US18512009

申请日：2023-11-16

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mauricio Guerrero ,  Brian Patrick Murphy ,  Travis Zenyo Oba ,  Sam Shafigh ,  Mark Chau ,  Kevin Gantz ,  Meena Francis ,  Murrad Mirza Kazalbash

IPC: A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61B17/32

CPC classification number: A61B17/00234 ,  A61B17/0469 ,  A61B17/06066 ,  A61B17/32 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/0038 ,  A61B2017/06052 ,  A61B2017/06076 ,  A61B2017/061 ,  A61B2017/32006

Abstract: A system, for use with a leaflet of a valve of a subject's heart, comprises a catheter, a cutting device, a helical needle, and a suture. The catheter is transluminally advanceable toward the heart. The cutting device is advanceable distally out of the catheter, and is adapted to cut through tissue of the leaflet to form cut tissue and cut edges at the cardiac valve. The helical needle defines a helical lumen, the helical needle configured to be advanced distally out of the catheter and to rotationally extend through, and secure together, two tissue segments of the leaflet. The suture extends through the helical lumen of the helical needle. The helical needle and the suture are configured to extend along the two tissue segments of the leaflet to suture the two tissue segments to each other. Other embodiments are also described.

公开(公告)号：US20240041602A1

公开(公告)日：2024-02-08

申请号：US18489666

申请日：2023-10-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mark Chau ,  David M. Taylor ,  Alexander J. Siegel ,  Christopher J. Olson ,  Sergio Delgado ,  Alexander H. Cooper ,  Lauren R. Freschauf ,  Asher L. Metchik ,  Matthew T. Winston ,  Cristobal R. Hernandez ,  Emil Karapetian ,  Bao Khuu ,  Eric Robert Dixon ,  Amanda French ,  Philip P. Corso, JR.

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2466 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2220/0016 ,  A61F2310/00023

Abstract: In one example, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. A size of the spacer body is configured to be adjusted after the spacer body is placed between the native valve leaflets and the pair of anchors are placed against the ventricular surfaces of the native heart valve leaflets. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

公开(公告)号：US20230285142A1

公开(公告)日：2023-09-14

申请号：US18199884

申请日：2023-05-19

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Zenyo Oba

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2427 ,  A61F2/246 ,  A61F2/2418 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2250/0063 ,  A61F2230/0069 ,  A61F2250/006 ,  A61F2210/0014

Abstract: A system for replacing a native valve of the heart includes a delivery apparatus having a sheath and a prosthetic valve. The prosthetic valve includes a frame having an annular main body, a plurality of ventricular anchors attached to the main body, an atrial anchor attached to an atrial end portion of the main body, and a valve structure disposed within the main body of the frame. The prosthetic valve is disposed within a distal end portion of the sheath in a compressed, delivery state. When the prosthetic valve is deployed from the sheath, the main body of the frame radially expands to a radially expanded state, the ventricular anchors expand to a deployed state alongside the main body of the frame for capturing native leaflets of the native valve, and the atrial anchor expands to a deployed state extending radially outwardly from the main body.

公开(公告)号：US20230190458A1

公开(公告)日：2023-06-22

申请号：US18109075

申请日：2023-02-13

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Zenyo Oba

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2427 ,  A61F2/246 ,  A61F2/2418 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/006 ,  A61F2250/0063 ,  A61F2220/0016 ,  A61F2230/0069

Abstract: A prosthetic heart valve for implantation at a native heart valve includes a multi-part frame. The multi-part frame includes a cylindrical main body and a ventricular anchor component surrounding the main body. The main body includes a plurality of struts arranged in a lattice pattern. The ventricular anchor component is attached to the main body only at an outflow end of the main body and extends toward an inflow end of the main body. The prosthetic valve further includes a valve structure having three leaflets made from pericardium. The multi-part frame is radially compressible for delivery within a sheath of a delivery catheter and is self-expandable for deployment within an annulus of the native valve. The main body and the ventricular anchor component are formed separately and are attached by a locking mechanism for reducing strain between the main body and the ventricular anchor component.

公开(公告)号：US11583396B2

公开(公告)日：2023-02-21

申请号：US17008231

申请日：2020-08-31

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Zenyo Oba

IPC: A61F2/24

Abstract: A prosthetic apparatus for implantation in a native heart valve includes a main body for placement within the native annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation. A valve structure is mounted within a lumen of the main body and preferably forms three leaflets made of pericardium. Ventricular anchors are coupled to a ventricular end portion of the main body. The ventricular anchors are adapted to be straightened for delivery to the native heart valve and are biased to spring back to a pre-formed bent shape for capturing the native heart valve leaflets between the main body and the ventricular anchors. An atrial sealing member may be provided along an atrial portion of the main body for impeding the flow of blood between the main body and the native annulus.

公开(公告)号：US11504232B2

公开(公告)日：2022-11-22

申请号：US17067618

申请日：2020-10-09

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Zenyo Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

Abstract: A heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve has a base stent that is deployed at a treatment site, and a valve component configured to quickly connect to the base stent. The base stent may take the form of a self- or balloon-expandable stent that expands outward against the native valve with or without leaflet excision. The valve component has a non-expandable prosthetic valve and a self- or balloon-expandable coupling stent for attachment to the base stent, thereby fixing the position of the valve component relative to the base stent. The prosthetic valve may be a commercially available to valve with a sewing ring and the coupling stent attaches to the sewing ring. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment. A catheter-based system and method for deployment is provided.

公开(公告)号：US20210196457A1

公开(公告)日：2021-07-01

申请号：US17203611

申请日：2021-03-16

Applicant: Edwards Lifesciences Corporation

Inventor： Stanton J. Rowe ,  Mark Chau ,  Son V. Nguyen

IPC: A61F2/24 ,  A61L27/50 ,  A61F2/90 ,  A61L27/36

Abstract: A prosthetic heart valve assembly includes a self-expandable stent having an inlet end and an outlet end and a passageway extending therethrough. The stent includes a plurality of rows of prongs on the outer surface of the stent. A valve portion comprising a plurality of leaflets is positioned within the passageway for permitting blood to flow through the passageway from the inlet end to the outlet end while blocking flow in the opposite direction. The stent further includes a flared upper portion shaped for placement along a supra-annular surface of an annulus for preventing downward migration of the prosthetic valve assembly into a ventricle. Each of the prongs has a tip pointing toward the inlet end for penetrating surrounding tissue and preventing upward migration of the prosthetic heart valve assembly toward an atrium.

公开(公告)号：US20210022856A1

公开(公告)日：2021-01-28

申请号：US17066048

申请日：2020-10-08

Applicant: Edwards Lifesciences Corporation

Inventor： Stephen C. Geist ,  Robert C. Taft ,  Travis Zenyo Oba ,  Sam Sok ,  Matthew A. Peterson ,  Kevin M. Golemo ,  Mark Chau ,  Seung-Beom Yi

IPC: A61F2/24

Abstract: A method for heart valve replacement comprises forming an incision in a wall of a ventricle of a heart and inserting a delivery apparatus and a prosthetic heart valve through the incision and into the ventricle of the heart. The prosthetic valve comprises a self-expanding frame having an annular main body and a valve member disposed within the annular main body. The prosthetic valve further comprises an atrial sealing member formed by an annular metal ring and a fabric, wherein only the fabric of the atrial sealing member is connected to the main body for enhancing the flexibility and conformability of the atrial sealing member. The method further comprises deploying the prosthetic valve from the delivery apparatus such that the atrial sealing member extends radially outwardly from the main body within an atrium of the heart and the main body self-expands to a deployed state within a native heart valve.

公开(公告)号：US20200315792A1

公开(公告)日：2020-10-08

申请号：US16906672

申请日：2020-06-19

Applicant: Edwards Lifesciences Corporation

Inventor： Stephen C. Geist ,  Robert C. Taft ,  Travis Zenyo Oba ,  Sam Sok ,  Matthew A. Peterson ,  Kevin M. Golemo ,  Mark Chau ,  Seung-Beom Yi

IPC: A61F2/24

Abstract: An implantable prosthetic valve includes a radially collapsible and radially expandable annular frame. The frame includes an annular main body sized to be implanted within a native mitral valve annulus. The frame also includes an atrial sealing member coupled to and extending radially away from the main body. The atrial sealing member is sized to extend over tissue of the native mitral annulus within a left atrium to reduce paravalvular leakage. The atrial sealing member includes an inner zig-zag portion and an outer zig-zag portion. The inner zig-zag portion and the outer zig-zag portion are connected to the main body portion only via a fabric to enhance flexibility of the atrial sealing member relative to the main body. The prosthetic valve also includes a valve member disposed within an interior of the frame.

公开(公告)号：US10555810B2

公开(公告)日：2020-02-11

申请号：US15905625

申请日：2018-02-26

Applicant: Edwards Lifesciences Corporation

Inventor： Rafael Pintor ,  Mark Chau ,  Travis Zenyo Oba ,  August R. Yambao ,  Louis A. Campbell ,  Tammy Huntley ,  Qinggang Zeng ,  Carey L. Cristea ,  Faisal Kalam

IPC: A61F2/24

Abstract: A quick-connect heart valve prosthesis that can be quickly and easily implanted is provided. The heart valve includes a substantially non-expandable, non-compressible prosthetic valve and a plastically-expandable coupling stent, thereby enabling attachment to the annulus without sutures. A small number of guide sutures may be provided for aortic valve orientation. The prosthetic valve may be a commercially available valve with a sewing ring with the coupling stent attached thereto. The coupling stent may expand from a conical deployment shape to a conical expanded shape, and may include web-like struts connected between axially-extending posts. A system and method for deployment includes a hollow two-piece handle through which a balloon catheter passes. A valve holder is stored with the heart valve and the handle easily attaches thereto to improve valve preparation steps.