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公开(公告)号：US11504229B2
公开(公告)日：2022-11-22
申请号：US16843122
申请日：2020-04-08
发明人： Travis Zenyo Oba , Matthew A. Peterson , Glen T. Rabito , Alexander H. Cooper , David Robert Landon , J. Brent Ratz , Seung-Beom Yi
摘要： A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.
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公开(公告)号：US20200297481A1
公开(公告)日：2020-09-24
申请号：US16843122
申请日：2020-04-08
发明人： Travis Zenyo Oba , Matthew A. Peterson , Glen T. Rabito , Alexander H. Cooper , David Robert Landon , J. Brent Ratz , Seung-Beom Yi
摘要： A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.
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公开(公告)号：US20200229919A1
公开(公告)日：2020-07-23
申请号：US16843826
申请日：2020-04-08
发明人： Stephen C. Geist , Robert C. Taft , Travis Oba , Sam Sok , Matthew A. Peterson , Kevin M. Golemo , Mark Chau , Seung-Beom Yi
IPC分类号： A61F2/24
摘要： A prosthetic device includes a main body, a first anchor, a second anchor, a first anchor spreader, and a second anchor spreader. The first anchor is coupled to the main body such that a spring force of the first anchor biases the first anchor toward the main body. The second anchor is coupled to the main body such that a spring force of the second anchor biases the second anchor against the main body. The first anchor spreader is coupled to the first anchor such that applying a force to the first anchor spreader moves the first anchor away from the main body against the spring force of the first anchor. The second anchor spreader is coupled to the second anchor such that applying a force to the second anchor spreader moves the second anchor away from the main body against the spring force of the second anchor.
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公开(公告)号：US20200038180A1
公开(公告)日：2020-02-06
申请号：US16597460
申请日：2019-10-09
摘要： A prosthetic valve assembly includes a support structure and a valve component. The support structure includes a first frame and a sealing member. The first frame includes a lumen extending between inflow and outflow ends. The sealing member extends inwardly into the lumen of the first frame and includes a first end wall defining a first orifice, a second end wall axially spaced from the first end wall and defining a second orifice, and an inner sleeve extending axially from the first end wall to the second end wall and spaced radially inwardly from the first frame. The valve component includes a second frame and a valve structure supported inside of the second frame for permitting blood flow through the valve component in one direction and blocking blood flow in the opposite direction. The valve component is configured to expand within and engage the inner sleeve of the sealing member.
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公开(公告)号：US10350062B2
公开(公告)日：2019-07-16
申请号：US15653390
申请日：2017-07-18
发明人： Matthew A. Peterson , Seung-Beom Yi , Siddharth Vad , Travis Zenyo Oba , Lauren R. Freschauf , Amanda French , Yaron Keidar , Yuanlong Du , Gregory Bak-Boychuk , Kevin M. Golemo , Alexander H. Cooper
IPC分类号： A61F2/24
摘要： A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.
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公开(公告)号：US09717591B2
公开(公告)日：2017-08-01
申请号：US15227238
申请日：2016-08-03
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2418 , A61F2/2427 , A61F2/2445 , A61F2/246 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2230/0069 , A61F2250/006 , A61F2250/0063
摘要： A prosthetic apparatus for implantation in a native mitral valve includes a main body for placement within the native mitral annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation. A valve structure is mounted within a lumen of the main body and preferably forms three leaflets made of pericardium. An atrial sealing member is disposed along an atrial portion of the main body and ventricular anchors are coupled to a ventricular portion of the main body. The atrial sealing member impedes the flow of blood between the main body and the native annulus. The ventricular anchors are positioned outside the main body for capturing native mitral valve leaflets between the main body and the ventricular anchors.
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公开(公告)号：US20160310268A1
公开(公告)日：2016-10-27
申请号：US15134172
申请日：2016-04-20
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61B17/00234 , A61B2017/00243 , A61F2/2433 , A61F2/2436 , A61F2210/0014 , A61F2220/0016 , A61F2220/0075 , A61F2230/0065 , A61F2250/0059 , A61F2250/0063 , A61F2250/0069
摘要： In one representative embodiment, a prosthetic valve assembly for replacing a native heart valve comprises a radially expandable and compressible support structure, the support structure comprising an annular frame having a lumen extending from an inflow end to an outflow end, the support structure further comprising an annular sealing member extending radially inwardly into the lumen of the frame and having an inner peripheral portion defining an orifice, and a radially expandable and compressible valve component, the valve component comprising an annular frame and a valve structure supported inside of the frame for permitting the flow blood through the valve component in one direction and blocking the flow of blood in the opposite direction, wherein the valve component is configured to expand within the orifice of the sealing member and engage the inner peripheral portion of the sealing member when radially expanded.
摘要翻译： 在一个代表性的实施例中，用于替换天然心脏瓣膜的人造瓣膜组件包括径向可膨胀和可压缩的支撑结构，所述支撑结构包括具有从流入端延伸到流出端的内腔的环形框架，所述支撑结构还包括 环形密封构件径向向内延伸到框架的内腔中并具有限定孔口的内周部分和径向可膨胀和可压缩的阀部件，该阀部件包括支撑在框架内部的环形框架和阀结构，以允许 在一个方向上将血液流经阀组件，并阻止血液沿相反方向流动，其中阀部件构造成在密封部件的孔口内膨胀，并且当径向扩张时与密封部件的内周部分接合。
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公开(公告)号：US09439763B2
公开(公告)日：2016-09-13
申请号：US14171603
申请日：2014-02-03
发明人： Stephen C. Geist , Robert C. Taft , Travis Oba , Sam Sok , Matthew A. Peterson , Kevin M. Golemo , Mark Chau , Seung-Beom Yi
CPC分类号： A61F2/2418 , A61B6/4441 , A61B8/12 , A61F2/2409 , A61F2/2412 , A61F2/2436 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0018 , A61F2250/0029 , A61F2250/0069
摘要： Embodiments of prosthetic valves for implantation within a native mitral valve are provided. One embodiment of a prosthetic valve includes a radially compressible main body and a one-way valve member. In some cases, the prosthetic valves also include ventricular anchors and/or an atrial portion coupled to and disposed outside of the main body. Methods, devices, and systems for delivering such prosthetic valves to the native mitral valve and implanting them therein are also provided.
摘要翻译： 提供了用于植入在天然二尖瓣内的人工瓣膜的实施例。 假体瓣膜的一个实施例包括可径向压缩的主体和单向阀构件。 在一些情况下，假体瓣膜还包括联接到并设置在主体外侧的心室锚和/或心房部分。 还提供了用于将这种假性瓣膜递送到天然二尖瓣并将其植入其中的方法，装置和系统。
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公开(公告)号：US12083010B2
公开(公告)日：2024-09-10
申请号：US16670449
申请日：2019-10-31
发明人： Stephen C. Geist , Robert C. Taft , Travis Zenyo Oba , Sam Sok , Matthew A. Peterson , Kevin M. Golemo , Mark Chau , Seung-Beom Yi
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2436 , A61F2/2466 , A61B6/4441 , A61B8/12 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0018 , A61F2250/0029 , A61F2250/0069
摘要： A method of implanting a prosthetic apparatus preferably includes delivering the prosthetic apparatus to a native mitral valve and exposing ventricular anchors and a spacer body of the prosthetic apparatus from a distal end portion of a delivery apparatus. The ventricular anchors are controllably and forcibly expanded outwardly from the spacer body to an expanded configuration. The prosthetic apparatus is positioned relative to the native mitral valve such that native mitral valve leaflets are located between the ventricular anchors and the spacer body. The ventricular anchors are then contracted radially inwardly toward the spacer body to a compressed configuration. In the compressed configuration, the native mitral valve leaflets are secured between the ventricular anchors and the spacer body. After implantation, the spacer body is held between the native mitral valve leaflets, thereby blocking regurgitation and improving the function of the native mitral valve.
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公开(公告)号：US20230285142A1
公开(公告)日：2023-09-14
申请号：US18199884
申请日：2023-05-19
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2427 , A61F2/246 , A61F2/2418 , A61F2/2409 , A61F2/2445 , A61F2220/0008 , A61F2220/0016 , A61F2250/0063 , A61F2230/0069 , A61F2250/006 , A61F2210/0014
摘要： A system for replacing a native valve of the heart includes a delivery apparatus having a sheath and a prosthetic valve. The prosthetic valve includes a frame having an annular main body, a plurality of ventricular anchors attached to the main body, an atrial anchor attached to an atrial end portion of the main body, and a valve structure disposed within the main body of the frame. The prosthetic valve is disposed within a distal end portion of the sheath in a compressed, delivery state. When the prosthetic valve is deployed from the sheath, the main body of the frame radially expands to a radially expanded state, the ventricular anchors expand to a deployed state alongside the main body of the frame for capturing native leaflets of the native valve, and the atrial anchor expands to a deployed state extending radially outwardly from the main body.
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