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93 条记录 (耗时 0.027 秒)

    Antimycotic agents
    51.
    发明授权
    Antimycotic agents 失效
    抗真菌剂

    公开(公告)号：US4925865A

    公开(公告)日：1990-05-15

    申请号：US246729

    申请日：1988-09-20

    申请人： Klaus Stroech ,  Monika Frie ,  Thomas Himmler ,  Manfred Plempel

    发明人： Klaus Stroech ,  Monika Frie ,  Thomas Himmler ,  Manfred Plempel

    IPC分类号： A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D405/08 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Combating mycoses in humans and other animals with hydroxyalkyl-azolyl derivatives of the formula ##STR1## in which R stands for hydrogen, alkyl or acyl,R.sup.1 stands for halogen, optionally substituted phenyl or the --Z--R.sup.3 grouping,R.sup.2 stands for optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted naphthyl, for the radical of the formula ##STR2## or for the radical of the formula ##STR3## X stands for nitrogen or a CH group and Y stands for the --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, ##STR4## groupings, whereinR.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently of one another stand for hydrogen or alkyl having 1 to 4 carbon atoms,and their acid addition salts.

    摘要翻译： 在人类和其他动物中与下列化合物的羟基烷基 - 唑基衍生物（I）抗真菌病，其中R代表氢，烷基或酰基，R1代表卤素，任选取代的苯基或-Z-R3基，R2代表 对于任选取代的烷基，任选取代的环烷基，任选取代的萘基，对于式的基团或对于式的基团，X代表氮或CH基团，Y代表-CH 2 -CH 2 - ，其中R5，R6，R7和R8彼此独立地代表氢或具有1-4个碳原子的烷基，以及它们的酸加成盐。

    Novel substituted hydroxyalkyl-azole antimycotic agents
    52.
    发明授权
    Novel substituted hydroxyalkyl-azole antimycotic agents 失效
    新型取代的羟烷基 - 唑类抗真菌剂

    公开(公告)号：US4806559A

    公开(公告)日：1989-02-21

    申请号：US757033

    申请日：1985-07-18

    申请人： Hans-Ludwig Elbe ,  Jorg Stetter ,  Karl H. Buchel ,  Klaus Schaller ,  Manfred Plempel

    发明人： Hans-Ludwig Elbe ,  Jorg Stetter ,  Karl H. Buchel ,  Klaus Schaller ,  Manfred Plempel

    IPC分类号： A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D303/22 ,  C07D521/00 ,  A01N43/64

    CPC分类号： C07D303/22 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： An antimycotic agent, comprising a compound of the formula ##STR1## in which R.sup.1 is hydrogen, alkyl, optionally substituted phenyl or optionally substituted benzyl,R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, optionally substituted phenyl or optionally substituted benzyl,R.sup.3 and Y each independently is halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenoxyalkyl,R.sup.4 and R.sup.5 each independently is alkyl,X is a nitrogen atom or the CH group,m is 0, 1, 2 or 3,n is 1 or 2, andp is 0, 1 or 2,or an acid addition salt thereof.

    摘要翻译： 一种抗真菌剂，其包含其中R 1为氢，烷基，任选取代的苯基或任选取代的苄基的式“IMAGE”化合物，R 2为氢，烷基，烯基，炔基，任选取代的苯基或任选取代的苄基，R 3和Y 各自独立地是卤素，烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基，卤代烷硫基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基或任选取代的苯氧基烷基，R 4和R 5各自独立地是烷基，X是氮原子或 CH基，m为0,1,2或3，n为1或2，p为0,1或2，或其酸加成盐。

    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes
    57.
    发明授权
    Acylated imidazolyl-O,N-acetals, their pharmaceutically acceptable salts and metal complexes 失效
    酰化咪唑基-O，N-缩醛，其药学上可接受的盐和金属络合物

    公开(公告)号：US4153692A

    公开(公告)日：1979-05-08

    申请号：US872901

    申请日：1978-01-27

    申请人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Wolfgang Kramer ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： C07D521/00 ,  A61K31/415 ,  A61K31/555

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Acylated imidazolyl-O,N-acetals of the formula ##STR1## and their pharmaceutically acceptable salts and metal complexes wherein R is alkyl, alkenyl, alkinyl, cycloalkyl, halogenoalkyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, alkylamino, dialkylamino or optionally substituted phenylamino;X is halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, amino, cyano or nitro; andN is 0 or an integer of from 1 to 5;Are useful as antimicrobial agents, particularly for their use in treating mycotic infections in humans and animals.

    摘要翻译： 具有式（I）的酰化咪唑基-O，N-缩醛及其药学上可接受的盐和金属络合物，其中R是烷基，烯基，炔基，环烷基，卤代烷基，任选取代的苯基，任选取代的苯氧基烷基，烷基氨基，二烷基氨基或 任选取代的苯基氨基; X是卤素，烷基，环烷基，烷氧基，卤代烷基，烷硫基，烷氧基羰基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，氨基，氰基或硝基; 和N是0或1到5的整数; 有用的抗微生物剂，特别是用于治疗人类和动物的肌肉感染。