公开(公告)号：US5658515A

公开(公告)日：1997-08-19

申请号：US533425

申请日：1995-09-25

申请人： Abraham P. Lee ,  M. Allen Northrup ,  Paul E. Ahre ,  Peter C. Dupuy

发明人： Abraham P. Lee ,  M. Allen Northrup ,  Paul E. Ahre ,  Peter C. Dupuy

IPC分类号： B29C33/42 ,  B29C33/40

CPC分类号： B29C33/42 ,  Y10T29/49995

摘要： A mold assembly with micro-sized features in which the hollow portion thereof is fabricated from a sacrificial mandrel which is surface treated and then coated to form an outer shell. The sacrificial mandrel is then selectively etched away leaving the outer shell as the final product. The sacrificial mandrel is fabricated by a precision lathe, for example, so that when removed by etching the inner or hollow area has diameters as small as 10's of micros (.mu.m). Varying the inside diameter contours of the mold can be accomplished with specified ramping slopes formed on the outer surface of the sacrificial mandrel, with the inside or hollow section being, for example, 275 .mu.m in length up to 150 .mu.m in diameter within a 6 mm outside diameter (o.d.) mold assembly. The mold assembly itself can serve as a micronozzle or microneedle, and plastic parts, such as microballoons for angioplasty, polymer microparts, and microactuators, etc., may be formed within the mold assembly.

摘要翻译： 具有微尺寸特征的模具组件，其中的中空部分由牺牲心轴制成，所述牺牲心轴经表面处理然后涂覆以形成外壳。 然后选择性地蚀刻牺牲心轴，离开外壳作为最终产品。 例如，通过精密车床制造牺牲心轴，使得当通过蚀刻去除时，内部或中空区域具有小至10微米（μm）的直径。 改变模具的内径轮廓可以通过形成在牺牲心轴的外表面上的规定的斜坡来实现，其中内部或中空部分的长度例如为275μm，直径在150μm以内 6 mm外径（od）模具总成。 模具组件本身可以用作微型喷嘴或微针，并且可以在模具组件内形成塑料部件，例如用于血管成形术的微球，聚合物微型部件和微型致动器等。

公开(公告)号：US5646039A

公开(公告)日：1997-07-08

申请号：US473275

申请日：1995-06-06

申请人： M. Allen Northrup ,  Richard M. White

发明人： M. Allen Northrup ,  Richard M. White

IPC分类号： C12N15/09 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  C12Q1/68 ,  G01N1/00 ,  G01N29/02 ,  G01N35/00 ,  G01N37/00 ,  C12M1/02 ,  C12M1/42

CPC分类号： B01L7/52 ,  B01F11/0266 ,  B01F13/0059 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/50273 ,  B01L7/525 ,  G01N29/022 ,  G01N35/00 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00932 ,  B01J2219/00934 ,  B01J2219/00952 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0436 ,  B01L9/527 ,  G01N2035/00237 ,  G01N2035/00554 ,  G01N2291/02466 ,  G01N2291/0256 ,  G01N2291/0421 ,  G01N35/1079 ,  Y10S73/04

摘要： An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of the instrument provides accurate, contamination-free processing. The instrument may include reagent reservoirs, agitators and mixers, heaters, pumps, and optical or electromechanical sensors. Ultrasonic Lamb-wave devices may be used as sensors, pumps and agitators.