公开(公告)号：US06812327B1

公开(公告)日：2004-11-02

申请号：US09507968

申请日：2000-02-22

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K3816

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地提供编码人Neutrokine-α和/或Neutrokine-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 Neutrokine-α和/或Neutrokine-αSV激动剂和Neutrokine-α和/或Neutrokine-αSV活性的拮抗剂。 也生产相同。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06790826B2

公开(公告)日：2004-09-14

申请号：US10004832

申请日：2001-12-07

申请人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik Olsen ,  Craig A. Rosen

发明人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik Olsen ,  Craig A. Rosen

IPC分类号： A61K3816

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.

摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，并且使用这些多肽来治疗白血病，自身免疫疾病和与血液相关的疾病。 还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。 还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。

公开(公告)号：US06774216B2

公开(公告)日：2004-08-10

申请号：US10115123

申请日：2002-04-04

申请人： Steven M. Ruben ,  Craig A. Rosen ,  David W. LaFleur

发明人： Steven M. Ruben ,  Craig A. Rosen ,  David W. LaFleur

IPC分类号： C07K1618

CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/47 ,  G01N2500/20

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06635482B1

公开(公告)日：2003-10-21

申请号：US09589286

申请日：2000-06-08

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： C12N506

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06607726B1

公开(公告)日：2003-08-19

申请号：US09769402

申请日：2001-01-26

申请人： Jian Ni ,  Craig A. Rosen

发明人： Jian Ni ,  Craig A. Rosen

IPC分类号： A61K3900

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C12N2799/026

摘要： The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族和TRAIL受体亚家族成员的新蛋白质TR10。 特别地，提供编码人TR10蛋白的分离的核酸分子。 还提供TR10多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR10活性的激动剂和拮抗剂的筛选方法。

公开(公告)号：US06605592B2

公开(公告)日：2003-08-12

申请号：US09800729

申请日：2001-03-08

申请人： Jian Ni ,  Kevin P. Baker ,  Charles E. Birse ,  Reinhard Ebner ,  Michele Fiscella ,  George A. Komatsoulis ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Ping Wei ,  Kimberly A. Florence

发明人： Jian Ni ,  Kevin P. Baker ,  Charles E. Birse ,  Reinhard Ebner ,  Michele Fiscella ,  George A. Komatsoulis ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Ping Wei ,  Kimberly A. Florence

IPC分类号： C07K1447

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application relates to a novel human protein, Protein HOFNF53. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 特别地，本申请涉及新的人蛋白质蛋白质HOFNF53。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US06583270B2

公开(公告)日：2003-06-24

申请号：US09386380

申请日：1999-08-31

申请人： Craig A. Rosen ,  Joseph J. Kenny

发明人： Craig A. Rosen ,  Joseph J. Kenny

IPC分类号： C07K1454

CPC分类号： C07K14/54 ,  A61K38/00 ,  Y02A50/41

摘要： The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further concerns therapeutic methods for modulating cytokine production.

摘要翻译： 本发明涉及一种新的人细胞因子。 特别地，提供编码白细胞介素-19（IL-19）的分离的核酸分子。 还提供了IL-19多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及调节细胞因子产生的治疗方法。

公开(公告)号：US06531447B1

公开(公告)日：2003-03-11

申请号：US09690454

申请日：2000-10-18

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Kenneth C. Carter ,  Patrick J. Dillon ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Kenneth C. Carter ,  Patrick J. Dillon ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

IPC分类号： C07K1400

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/525 ,  G01N2500/04

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06521227B1

公开(公告)日：2003-02-18

申请号：US09461418

申请日：1999-12-18

申请人： Peter L. Hudson ,  Craig A. Rosen ,  Wei Wu He

发明人： Peter L. Hudson ,  Craig A. Rosen ,  Wei Wu He

IPC分类号： A61K3942

CPC分类号： C07K14/575 ,  A61K39/00 ,  C07K16/22

摘要： The present invention relates to human PGF polypeptides, DNA (RNA) encoding such polypeptides, and antibodies specifically binding such polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques, and for producing antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating prostate cancer, promoting tissue regeneration, and facilitating wound healing. Further provided are methods of using such antibodies therapeutically to inhibit the action of PGF polypeptides and for the treatment of PGF-dependent tumors. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.

摘要翻译： 本发明涉及人PGF多肽，编码这种多肽的DNA（RNA）和与这些多肽特异性结合的抗体。 还提供了通过重组技术产生这种多肽的方法，以及用于产生抗这种多肽的抗体和拮抗剂/抑制剂。 还提供了用于治疗前列腺癌，促进组织再生和促进伤口愈合的方法。 进一步提供的是使用这种抗体治疗性地抑制PGF多肽的作用和用于治疗PGF依赖性肿瘤的方法。 还提供了用于检测前列腺癌和良性前列腺增生的诊断测定法。

公开(公告)号：US06518404B1

公开(公告)日：2003-02-11

申请号：US09520210

申请日：2000-03-07

申请人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

发明人： Yi Li ,  Craig A. Rosen ,  Chandrika Kumar

IPC分类号： C07K1628

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/72 ,  C07K14/723 ,  C12N2799/026

摘要： A human endothelin-bombesin receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for disclosed. Also disclosed are methods for utilizing such polypeptide for identifying agonists and antagonists to such polypeptide. Agonists to the endothelin-bombesin receptor polypeptide of the present invention may be used to treat asthma, Parkinson's Disease, acute heart failure, hypotension and osteoporosis. Antagonists against such polypeptides may be used therapeutically to treat hypertension, ulcerigenesis, subarachnoid hemorrhage, asthma, tumors, ciclosporin toxicity, cancer and septic shock. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

摘要翻译： 人内皮素 - 铃蟾肽受体多肽和编码这种多肽的DNA（RNA）和用于公开的方法。 还公开了利用这种多肽识别这种多肽的激动剂和拮抗剂的方法。 本发明的内皮素 - 铃蟾肽受体多肽的激动剂可用于治疗哮喘，帕金森病，急性心力衰竭，低血压和骨质疏松症。 抗这种多肽的拮抗剂可以治疗性地用于治疗高血压，溃疡发生，蛛网膜下腔出血，哮喘，肿瘤，环孢菌素毒性，癌症和败血性休克。 还公开了用于检测本发明的多核苷酸中的突变并用于检测衍生自宿主的样品中可溶性多肽的水平的诊断方法。