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    METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT
    53.
    发明申请
    METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE USING FLUORESCENCE MEASUREMENT 审中-公开
    使用荧光测量法确定分析仪浓度的方法和装置

    公开(公告)号：US20100227348A1

    公开(公告)日：2010-09-09

    申请号：US12696665

    申请日：2010-01-29

    申请人： Wolfgang Petrich ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn

    发明人： Wolfgang Petrich ,  Hans-Peter Haar ,  Joachim Hoenes ,  Carina Horn

    IPC分类号： C12Q1/54 ,  C12M1/34

    CPC分类号： C12Q1/32 ,  C12Q1/54

    摘要： A method is presented for determining the concentration of an analyte in a liquid sample using a reagent system. The reaction of the sample with the reagent system results in a change of the quantity of a fluorophore, the quantity of the fluorophore correlating with the concentration of the analyte, a characteristic measurement variable for the quantity of the fluorophore being measured, and the concentration of the analyte being determined using an evaluation algorithm on the basis of the measurement variable. The reagent system is integrated in an analysis system and the fluorescence lifetime of the fluorophore is used in the ascertainment of the concentration of the analyte.

    摘要翻译： 提出了一种使用试剂系统确定液体样品中分析物浓度的方法。 样品与试剂系统的反应导致荧光团量的变化，荧光团的量与分析物的浓度相关，测量的荧光团的量的特征测量变量和浓度 使用基于测量变量的评估算法确定分析物。 试剂系统集成在分析系统中，荧光团的荧光寿命用于确定分析物的浓度。

    Infusion system
    54.
    发明申请
    Infusion system 有权
    输液系统

    公开(公告)号：US20100211011A1

    公开(公告)日：2010-08-19

    申请号：US12542047

    申请日：2009-08-17

    申请人： Hans-Peter Haar

    发明人： Hans-Peter Haar

    IPC分类号： A61M5/142

    CPC分类号： A61M5/14248 ,  A61B5/14532 ,  A61M5/14566 ,  A61M5/16854 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/52 ,  A61M2205/8206 ,  A61M2209/045 ,  A61M2209/086

    摘要： Disclosed is an infusion system for administering a liquid medicament, particularly insulin. Said infusion system comprises a cannula support unit which is properly attached to a patient's body, an infusion cannula to be inserted into the patient's body, and a pump unit that can be connected to the cannula support unit and encompasses a pump, a battery for supplying power to the pump, and a storage volume for the medicament that is to be administered. The pump unit and the cannula support unit are adapted to one another in such a way that the pump unit rests against the cannula support unit once the pump unit has been connected to the cannula support unit. The disclosed infusion system also comprises a charging station for the pump unit in order to recharge the battery of the pump unit.

    摘要翻译： 公开了一种用于施用液体药物，特别是胰岛素的输注系统。 所述输注系统包括适当地附接到患者身体的插管支撑单元，插入到患者体内的输液套管以及能够连接到套管支撑单元并包围泵，用于供应的电池的泵单元 泵的功率以及待施用的药物的储存体积。 泵单元和插管支撑单元彼此适配，使得一旦泵单元已经连接到插管支撑单元，泵单元就靠在套管支撑单元上。 所公开的输注系统还包括用于泵单元的充电站，以便为泵单元的电池再充电。

    ANALYSIS DEVICE FOR IN VIVO DETERMINATION OF AN ANALYTE IN A PATIENT'S BODY
    56.
    发明申请
    ANALYSIS DEVICE FOR IN VIVO DETERMINATION OF AN ANALYTE IN A PATIENT'S BODY 审中-公开
    分析病人体内分析仪的分析装置

    公开(公告)号：US20080114227A1

    公开(公告)日：2008-05-15

    申请号：US11937872

    申请日：2007-11-09

    申请人： Hans-Peter Haar ,  Bernd Rosicke

    发明人： Hans-Peter Haar ,  Bernd Rosicke

    IPC分类号： A61B5/05

    CPC分类号： A61B5/14514 ,  A61B5/0017 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865

    摘要： An analysis device for in vivo determination of an analyte in a patient's body, comprising a transdermal measurement probe (2) adapted to be introduced through the skin surface (4) into the body, with a probe head (6) including an electro-chemical analysis sensor (7) with two measurement electrodes (25, 26, 27), a body-wearable probe connection unit (3) adapted to be worn on the body and for connection to the transdermal measurement probe (2), a test circuit (22) connected with the measurement electrodes (25, 26, 27), wherein after contact of the measurement electrodes (25, 26, 27) with a body fluid the test circuit (22) generates a test signal characteristic for the desired analysis result, an evaluation circuit (23) for evaluating test signals from the test circuit (22) and for generating an information about the desired analysis result, wherein the test circuit (22) is integrated in the probe head (6) as part of probe head electronics (10), the probe head (6) is coupled to light conductor (8, 18), the probe head (6) includes an optical sensor (17) for converting electrical signals from the probe head electronics (10) into light signals, and for transmitting the light signals via the light conductor (8, 18) coupled to the probe head (6), and the probe connection unit (3) contains a light receiver (28) for receiving the light signals from the measurement probe (2) for further processing.

    摘要翻译： 一种用于体内测定患者体内的分析物的分析装置，包括适于通过皮肤表面（4）引入体内的透皮测量探针（2），其中包括电化学 具有两个测量电极（25,26,27）的分析传感器（7），适于佩戴在身体上并用于连接到透皮测量探针（2）的身体穿戴性探针连接单元（3），测试电路 22）与所述测量电极（25,26,27）连接，其中在所述测量电极（25,26,27）与体液接触之后，所述测试电路（22）产生用于期望分析结果的特性的测试信号， 评估电路（23），用于评估来自测试电路（22）的测试信号并产生关于期望分析结果的信息，其中测试电路（22）集成在探头（6）中，作为探针头电子部件 （10），探头 头部（6）耦合到光导体（8,18），探头（6）包括用于将来自探头头部电子装置（10）的电信号转换为光信号的光学传感器（17），并用于发射光信号 通过耦合到探针头（6）的光导体（8,18），并且探针连接单元（3）包含用于接收来自测量探针（2）的光信号用于进一步处理的光接收器（28）。

    Laser array
    57.
    发明申请
    Laser array 审中-公开
    激光阵列

    公开(公告)号：US20080100851A1

    公开(公告)日：2008-05-01

    申请号：US11784684

    申请日：2007-04-09

    申请人： Jean-Michel Asfour ,  Hans-Peter Haar ,  Rudolf Pachl ,  Peter Seelig ,  Bernd Stenkamp ,  Volker Zimmer

    发明人： Jean-Michel Asfour ,  Hans-Peter Haar ,  Rudolf Pachl ,  Peter Seelig ,  Bernd Stenkamp ,  Volker Zimmer

    IPC分类号： G01B11/24

    CPC分类号： G06T7/0012 ,  G01N21/8483 ,  G06T2207/30024

    摘要： A system and method for the optical determination of the concentration of an analyte in a body fluid. The system comprises an analytical test element which has a support layer and a detection area arranged thereon which contains the reagents required for the detection of the analyte in a body fluid as well as an instrument which has an illumination unit with at least one light source, a detection unit and an evaluation unit. The detection unit is optically scanned with the illumination unit and the detection unit.

    摘要翻译： 用于光学测定体液中分析物浓度的系统和方法。 该系统包括分析测试元件，其具有布置在其上的支撑层和检测区域，其包含检测体液中的分析物所需的试剂以及具有至少一个光源的照明单元的仪器， 检测单元和评估单元。 用照明单元和检测单元对检测单元进行光学扫描。

    Analytical device for in vivo analysis in the body of a patient
    58.
    发明授权
    Analytical device for in vivo analysis in the body of a patient 失效
    用于体内分析的用于患者体内的分析装置

    公开(公告)号：US06584335B1

    公开(公告)日：2003-06-24

    申请号：US09485004

    申请日：2000-05-08

    申请人： Hans-Peter Haar ,  Gerhard Werner ,  Dirk Boecker ,  Armin Lambrecht ,  Joachim Kastner

    发明人： Hans-Peter Haar ,  Gerhard Werner ,  Dirk Boecker ,  Armin Lambrecht ,  Joachim Kastner

    IPC分类号： A61B500

    CPC分类号： G01N21/8507 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/6848 ,  A61B5/6849 ,  G02B6/241

    摘要： Analysis device for determining an analyte in vivo in the body of a patient, having a measuring probe with a hollow needle (18) which can pierce through the skin. Light is passed through the hollow needle (18) and into the body via an optical fiber (22) travelling in the hollow needle (18). The light transported in the optical fiber (22) is modified in the measuring probe (3), the modification being characteristic of the presence of the analyte. A measurement and evaluation unit (4) measures the change to extract information concerning the presence of the analyte in the body. The hollow needle (18) is permeable, at least in a partial section of its length, serving as a measuring section (30) which can be inserted into the skin so that interstitial liquid may penetrate through the hollow needle wall to a measuring section of the optical fiber extending in the hollow needle (18) and the modification of the light characteristic of the presence of the analyte is effected through interaction with the interstitial liquid in the measuring section.

    摘要翻译： 用于确定患者体内的分析物的分析装置，其具有带有可刺穿皮肤的空心针（18）的测量探针。 光通过中空针（18）通过在中空针（18）中行进的光纤（22）进入体内。 在光纤（22）中传输的光在测量探针（3）中被修改，该修改是分析物存在的特征。 测量和评估单元（4）测量改变以提取关于分析物在体内的存在的信息。 中空针（18）至少在其长度的局部剖面中是可渗透的，用作可插入皮肤的测量部分（30），使得间隙液可以穿过中空针壁穿过测量部分 在中空针（18）中延伸的光纤和通过与测量部中的间隙液的相互作用来实现分析物的存在的光特性的修改。

    Analytical system for monitoring a substance to be analyzed in patient-blood
    59.
    发明授权
    Analytical system for monitoring a substance to be analyzed in patient-blood 失效
    用于监测患者血液中待分析物质的分析系统

    公开(公告)号：US5507288A

    公开(公告)日：1996-04-16

    申请号：US434296

    申请日：1995-05-03

    申请人： Dirk Bocker ,  Hans-Peter Haar ,  Peter Blasberg ,  Reinhard Kotulla

    发明人： Dirk Bocker ,  Hans-Peter Haar ,  Peter Blasberg ,  Reinhard Kotulla

    IPC分类号： G01N33/52 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495

    CPC分类号： A61B5/6822 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2562/0295 ,  Y10S128/903

    摘要： Analytical system for monitoring patient blood concentration of a substance to be analyzed, comprising analysis-elements (12) containing reagents and an evaluation instrument comprising a measurement device to measure a change resulting from a reaction of the analyte with the reagents in order to determine, from the measurement values so obtained, analytical data representing element analysis data C.sub.A.In order to allow continuous monitoring of the analyte with good accuracy and a reduced number of invasive sample generation steps it is proposed that the analytical system further comprises (i) a sensor unit (2) portable on the patient body, said sensor unit (2) including a sensor (7) borne on the patient body for the direct and reagent-free measurement of a parameter correlating with the concentration of the analyzed substance and a transmitter for the wireless transmission of data signals; and (ii) a sensor-analysis means to ascertain sensor-analysis data C.sub.S from the measurement values of said parameter measured by said sensor; and the evaluation instrument further comprises a receiver to receive in wireless manner the data signals from the sensor unit (2), calibration means to calibrate the sensor-analysis data C.sub.S on the basis of the element-analysis data C.sub.A and (iii) a data memory for the long-term storage of analytical data, whereby said evaluation instrument forms a central unit (3) of an integrated analysis-element/sensor monitoring system (1).

    摘要翻译： 用于监测待分析物质的患者血液浓度的分析系统，包括含有试剂的分析元件（12）和包括测量装置的评估仪器，所述测量装置用于测量由分析物与试剂的反应产生的变化， 从如此获得的测量值，分析数据表示元素分析数据CA。 为了能够以良好的精度和较少数量的侵入性样本生成步骤连续监测分析物，建议分析系统还包括（i）便携式的患者体上的传感器单元（2），所述传感器单元（2 ），其包括承载在患者身上的传感器（7），用于直接和无试剂地测量与分析物质的浓度相关的参数和用于无线传输数据信号的发射器; 以及（ii）传感器分析装置，用于根据由所述传感器测量的所述参数的测量值来确定传感器分析数据CS; 并且所述评估仪器还包括以无线方式接收来自所述传感器单元（2）的数据信号的接收器，用于基于所述元素分析数据CA校准所述传感器分析数据CS的校准装置，以及（iii）数据 用于长期存储分析数据的存储器，由此所述评估仪器形成集成分析元件/传感器监测系统（1）的中央单元（3）。

    DETECTING THE DECOMPOSITION OF ENZYMES IN A TEST ELEMENT BY MEANS OF CONTROLLED RELEASE OF A PROTECTED ANALYTE
    60.
    发明申请
    DETECTING THE DECOMPOSITION OF ENZYMES IN A TEST ELEMENT BY MEANS OF CONTROLLED RELEASE OF A PROTECTED ANALYTE 审中-公开
    通过受保护分析仪的控制释放检测测试单元中酶的分解

    公开(公告)号：US20130052674A1

    公开(公告)日：2013-02-28

    申请号：US13524199

    申请日：2012-06-15

    申请人： Carina Horn ,  Dieter Heindl ,  Hans-Peter Haar ,  Nelli Steinke

    发明人： Carina Horn ,  Dieter Heindl ,  Hans-Peter Haar ,  Nelli Steinke

    IPC分类号： C12Q1/32 ,  G01N21/77 ,  C12Q1/54

    CPC分类号： C12Q1/54

    摘要： In one form, a diagnostic element for determining at least one analyte is provided. In a further form, an analytical measuring device includes the diagnostic element. Still, other forms are related to methods for the determination of an analyte, correcting a signal generated by an analyte, and/or checking the detection optics of an analytical measuring device using the diagnostic element. Another form is related to a system for the controlled release of a reagent and the use of such a system as a circuit element. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving diagnostic elements.

    摘要翻译： 在一种形式中，提供了用于确定至少一种分析物的诊断元件。 在另一种形式中，分析测量装置包括诊断元件。 仍然，其它形式涉及用于确定分析物的方法，校正由分析物产生的信号和/或使用诊断元件检查分析测量装置的检测光学元件。 另一种形式涉及用于控制释放试剂的系统以及使用诸如电路元件的系统。 其他方面包括但不限于涉及诊断元件的独特方法，技术，产品，系统和设备。