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206 条记录 (耗时 0.088 秒)

    Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
    51.
    发明授权
    Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha 失效
    编码肿瘤坏死因子-γ-α的核酸分子

    公开(公告)号：US06599719B2

    公开(公告)日：2003-07-29

    申请号：US09131237

    申请日：1998-08-07

    申请人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C12N1528

    CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K48/00 ,  Y10S930/14

    摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

    摘要翻译： 公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎性活性和刺激某些细胞类型的生长以治疗疾病， 示例再狭窄。 还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和TNF-γ-β多肽的过度表达的诊断方法。 还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

    Nucleic acid molecules encoding cytostatin II
    53.
    发明授权
    Nucleic acid molecules encoding cytostatin II 失效
    编码细胞抑素II的核酸分子

    公开(公告)号：US06329169B1

    公开(公告)日：2001-12-11

    申请号：US09043646

    申请日：1998-09-09

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

    IPC分类号： C12P2102

    CPC分类号： G01N33/57415 ,  A61K38/00 ,  C07K14/475

    摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。 本发明还涉及利用这些多核苷酸，多肽，激动剂和拮抗剂用于部分与研究，诊断和临床领域有关的应用的方法。

    Antibodies to human cystatin E
    54.
    发明授权
    Antibodies to human cystatin E 有权
    人类半胱氨酸蛋白酶抑制剂E的抗体

    公开(公告)号：US06300477B1

    公开(公告)日：2001-10-09

    申请号：US09241376

    申请日：1999-02-02

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： C07K1618

    CPC分类号： C07K14/8139 ,  A61K38/00

    摘要： Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such antibodies and antibody fragments for the purification and analysis of CysE polypeptides, as well as the diagnosis and treatment of CysE polypeptide associated diseases.

    摘要翻译： 公开了结合新的人CysE多肽的抗体和抗体片段。 还提供了用于产生抗体的方法。 还公开了利用这些抗体和抗体片段来纯化和分析CysE多肽的方法，以及CysE多肽相关疾病的诊断和治疗。

    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA
    57.
    发明申请
    METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 审中-公开
    使用抗体治疗中耳炎的方法

    公开(公告)号：US20100330073A1

    公开(公告)日：2010-12-30

    申请号：US12870394

    申请日：2010-08-27

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni

    IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/00 ,  C07K16/18

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Death domain containing receptor 5
    60.
    发明申请
    Death domain containing receptor 5 审中-公开
    含有受体5的死亡域

    公开(公告)号：US20080248046A1

    公开(公告)日：2008-10-09

    申请号：US12010106

    申请日：2008-01-18

    申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K16/2878 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2319/30

    摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。 本发明还涉及使用DR5特异性抗体（其可以是DR5活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。