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57 条记录 (耗时 0.035 秒)

    Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them
    54.
    发明授权
    Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them 有权
    取代的4-氨基-2-芳基环戊基[d]嘧啶，其制备方法及其用途和包含它们的药物制剂

    公开(公告)号：US07138398B2

    公开(公告)日：2006-11-21

    申请号：US10660489

    申请日：2003-09-12

    申请人： Ursula Schindler ,  Karl Schoenafinger ,  Hartmut Strobel

    发明人： Ursula Schindler ,  Karl Schoenafinger ,  Hartmut Strobel

    IPC分类号： C07D239/70 ,  A61K31/517 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D239/70

    摘要： The present invention relates to compounds of formula (I) wherein R1, R2 and R3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the treatment and prophylaxis of diseases, for example cardiovascular diseases such as hypertension, angina pectoris, heart failure, thrombosis and atherosclerosis. The compounds of formula (I) are able to modulate the body's own production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the treatment and prophylaxis ofisorders associated with an impaired cGMP balance. The invention also relates to methods for producing compounds of formula (I), to their use in the treatment and prophylaxis of the above diseases and in the preparation of medicaments for such diseases, and to pharmaceutical preparations containing the compounds of formula (I).

    摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3和R 3具有权利要求中给出的含义。 所述化合物是药物中有价值的活性剂，用于治疗和预防疾病，例如高血压，心绞痛，心力衰竭，血栓形成和动脉粥样硬化等心血管疾病。 式（I）化合物能够调节人体自身产生的环鸟苷酸（cGMP），并且通常适用于与受损的cGMP平衡相关的疾病的治疗和预防。 本发明还涉及制备式（I）化合物的方法，用于治疗和预防上述疾病以及用于制备这些疾病的药物，以及含有式（I）化合物的药物制剂。

    Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them
    55.
    发明授权
    Substituted 4-amino-2-aryl-tetrahydroquinazolines, their preparation, their use and pharmaceutical preparations comprising them 有权
    取代的4-氨基-2-芳基 - 四氢喹唑啉，其制备方法及其用途和包含它们的药物制剂

    公开(公告)号：US07045526B2

    公开(公告)日：2006-05-16

    申请号：US10674350

    申请日：2003-10-01

    申请人： Ursula Schindler ,  Karl Schönafinger ,  Hartmut Strobel

    发明人： Ursula Schindler ,  Karl Schönafinger ,  Hartmut Strobel

    IPC分类号： A61K31/55 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/517 ,  C07D417/02 ,  C07D413/02 ,  C07D43/02

    CPC分类号： C07D239/94

    摘要： The present invention relates to compounds of formula I: wherein R1, R2, and R3 have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases such as cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses, or atherosclerosis. Compounds of formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for the preparation of compounds of formula I, methods of therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, and pharmaceutical compositions which comprise at least one compound of formula I.

    摘要翻译： 本发明涉及式I化合物：其中R 1，R 2和R 3具有说明书中所示的含义，其中 是用于治疗和预防心血管疾病如高血压，心绞痛，心功能不全，血栓形成或动脉粥样硬化等疾病的有价值的药物活性化合物。 式I的化合物具有调节环鸟苷酸（cGMP）的内源性产生的能力，并且通常适用于治疗和预防与扰动的cGMP平衡相关的疾病状态。 本发明还涉及制备式I化合物的方法，治疗和预防指定疾病状态及其制备方法，以及包含至少一种式I化合物的药物组合物。

    Substituted 4-amino-2-aryl-tetrahydoquinazolines, their preparation, their use and pharmaceutical preparations comprising them
    56.
    发明授权
    Substituted 4-amino-2-aryl-tetrahydoquinazolines, their preparation, their use and pharmaceutical preparations comprising them 有权
    取代的4-氨基-2-芳基 - 四氢喹唑啉，其制备方法及其用途和包含它们的药物制剂

    公开(公告)号：US06660746B1

    公开(公告)日：2003-12-09

    申请号：US09497723

    申请日：2000-02-04

    申请人： Ursula Schindler ,  Karl Schönafinger ,  Hartmut Strobel

    发明人： Ursula Schindler ,  Karl Schönafinger ,  Hartmut Strobel

    IPC分类号： A61K31517

    CPC分类号： C07D239/94

    摘要： The present invention relates to compounds of formula I: wherein R1, R2, and R3 have the meanings indicated in the specification, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases such as cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses, or atherosclerosis. Compounds of formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for the preparation of compounds formula I, methods of therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, and pharmaceutical compositions which comprise at least one compound of formula I.

    摘要翻译： 本发明涉及式I化合物：其中R 1，R 2和R 3具有说明书中所述的含义，其是用于治疗和预防诸如心血管疾病的有价值的药物活性化合物 疾病如高血压，心绞痛，心功能不全，血栓形成或动脉粥样硬化。 式I的化合物具有调节环鸟苷酸（cGMP）的内源性产生的能力，并且通常适用于治疗和预防与扰动的cGMP平衡相关的疾病状态。 本发明还涉及制备式I化合物的方法，治疗和预防指定疾病状态及其制备方法，以及包含至少一种式I化合物的药物组合物。