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    Polymeric pharmaceutical agent for treatment of cancer and method for production of the same
    55.
    发明申请
    Polymeric pharmaceutical agent for treatment of cancer and method for production of the same 有权
    用于治疗癌症的聚合物药剂及其制备方法

    公开(公告)号：US20090062476A1

    公开(公告)日：2009-03-05

    申请号：US11918651

    申请日：2006-04-13

    申请人： Hiroshi Maeda ,  Khaled Greish

    发明人： Hiroshi Maeda ,  Khaled Greish

    IPC分类号： C08F8/30

    CPC分类号： A61K41/0071 ,  A61K9/0019 ,  A61K9/107 ,  A61K31/409 ,  A61K31/704 ,  A61K31/7048 ,  A61K47/58 ,  A61K47/60 ,  C08K5/0091 ,  C08L35/06

    摘要： The present invention provides a polymeric agent which can incorporate a large amount of a drug, accumulate selectively in a tumor site, and has a molecular size of more than that for renal excretion.A metalloporphyrin derivative (such as zinc protoporphyrin) is associated with a styrene-maleic acid copolymer via non-covalent bond to give a SMA micelle complex, allowing provision of a polymeric pharmaceutical agent for treatment of cancer with a large amount of the drug incorporated. The SMA micelle complex can be produced by a method, wherein the metalloporphyrin derivative reacts with the styrene-maleic acid copolymer in the absence of a condensation agent under an alkaline condition, solubilized, adjusted to have a pH of 6-8, and subjected to a procedure for separating a polymer component to recover the micelle complex component for the polymeric pharmaceutical agent.

    摘要翻译： 本发明提供了可以掺入大量药物的聚合物，其选择性地积聚在肿瘤部位，并且具有比肾排泄量更大的分子大小。 金属卟啉衍生物（例如锌原卟啉锌）通过非共价键与苯乙烯 - 马来酸共聚物缔合，得到SMA胶束复合物，允许提供用于治疗癌症的大量药物的聚合物药剂。 SMA胶束复合物可以通过一种方法制备，其中金属卟啉衍生物在碱性条件下在不存在缩合剂的情况下与苯乙烯 - 马来酸共聚物反应，溶解，调节至pH为6-8，并进行 用于分离聚合物组分以回收聚合物药剂的胶束复合物组分的方法。

    Electrophoretic display device, method of driving electrophoretic device, and electronic apparatus
    59.
    发明申请
    Electrophoretic display device, method of driving electrophoretic device, and electronic apparatus 有权
    电泳显示装置，电泳装置的驱动方法以及电子装置

    公开(公告)号：US20080238867A1

    公开(公告)日：2008-10-02

    申请号：US12077039

    申请日：2008-03-15

    申请人： Hiroshi Maeda ,  Yasuhiro Shimodaira

    发明人： Hiroshi Maeda ,  Yasuhiro Shimodaira

    IPC分类号： G09G3/34

    CPC分类号： G09G3/344 ,  G09G2300/0857 ,  G09G2320/0214 ,  G09G2330/021

    摘要： An electrophoretic display device includes a pair of substrates, an electrophoretic element that includes electrophoretic particles and that are held between the pair of substrates, and a display portion formed of a plurality of pixels. The display portion includes pixel electrodes, an opposite electrode, a first control line and a second control line. Each of the pixel electrodes is formed in each of the pixels. The opposite electrode is opposed to the plurality of pixel electrodes through the electrophoretic element. The first control line and the second control line are connected to each of the pixels. Each of the pixels includes a pixel switching element, a memory circuit, and a switch circuit. The memory circuit is connected to the pixel switching element. Switching of the switch circuit is performed by an output signal of the memory circuit to switch between a connected state where the pixel electrode is connected to the first control line and a connected state where the pixel electrode is connected to the second control line.

    摘要翻译： 电泳显示装置包括一对基板，包括电泳颗粒并且保持在该对基板之间的电泳元件和由多个像素形成的显示部分。 显示部分包括像素电极，相对电极，第一控制线和第二控制线。 每个像素电极形成在每个像素中。 相对电极通过电泳元件与多个像素电极相对。 第一控制线和第二控制线连接到每个像素。 每个像素包括像素开关元件，存储器电路和开关电路。 存储电路连接到像素开关元件。 开关电路的切换由存储电路的输出信号进行，以在像素电极连接到第一控制线的连接状态与像素电极连接到第二控制线的连接状态之间切换。