摘要:
An imine compound represented by the formula: wherein A represents a heterocyclic group; R1, R2, an R3 each represent a hydrogen atom, a halogen atom, a C1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C3-10 cycloalkyl group, a C1-6 haloalkyl group, a C1-10 alkoxy group, etc.; R4 represents an optionally substituted C1-10 alkyl, C2-6 alkenyl, or aryl group; R5 represents a hydrogen atom, a C1-10 alkoxy group, a C1-6 haloalkyl group, an optionally substituted C1-10 alkyl or C2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO2—, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.
摘要翻译:由下式表示的亚胺化合物:其中A表示杂环基; R 1,R 2,R 3各自表示氢原子,卤素原子,任选被被卤素原子取代的芳基取代的C 1-10烷基,C 3-10环烷基, 6卤代烷基,C1-10烷氧基等; R 4表示任选取代的C 1-10烷基,C 2-6烯基或芳基; R5表示氢原子,C1-10烷氧基,C1-6卤代烷基,任选取代的C 1-10烷基或C 2-6烯基,任选取代的芳基或杂环基等; W表示-CO-,-CO-CO-,-CO-NH-,-CS-NH-或-SO 2 - 或包含所述亚胺化合物作为活性成分的大麻素受体激动剂。 本发明的亚胺化合物具有大麻素受体激动剂作用,可用作疼痛和自身免疫疾病的治疗或预防药物。
摘要:
A semiconductor apparatus includes a first semiconductor layer, a second semiconductor layer provided on a major surface of the first semiconductor layer, a third semiconductor layer provided on the major surface and being adjacent to the second semiconductor layer, a termination semiconductor layer provided on the major surface of the first semiconductor layer in a termination region outside the device region, a channel stop layer, and a channel stop electrode. The channel stop layer is provided in contact with the termination semiconductor layer on the major surface of the first semiconductor layer in an outermost peripheral portion outside the termination semiconductor layer and has a higher impurity concentration than the termination semiconductor layer. The channel stop electrode is provided on at least part of a surface of the channel stop layer and projects toward the termination semiconductor layer beyond at least a superficial portion of the channel stop layer.
摘要:
One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases, inhibiting a Group II metabotropic glutamate receptor.The object is solved by a 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by formula [I]: (wherein R1 and R2 are the same or different, and each represents a hydrogen atom, C1-10alkyl group, etc; X represents a hydrogen atom or a fluorine atom; and Y represents an amino group, —SR3, —S(O)nR7, —SCHR3R4, —S(O)nCHR3R4, —NHCHR3R4, —N(CHR3R4)(CHR5R6), —NHCOR3 or —OCOR7), a pharmaceutically acceptable salt thereof, or a hydrate thereof and so on.
摘要翻译:本发明的一个目的是提供一种有效治疗和预防精神疾病以及治疗和预防神经系统疾病,抑制II族代谢型谷氨酸受体的药物。 该目的通过由式[I]表示的2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸衍生物来解决:(其中R 1和R 2) / SUP>相同或不同,各自表示氢原子,C 1-10烷基等; X表示氢原子或氟原子; Y表示氨基, - S 3 O 3,-S(O)n R 7,-SCHR 3,R 4, (S) - (O)n - , - CHR 3 - - - - - - SO 4 - , - -N(CHR 3 S 4)4(CHR 5 S 6),-NHCOR 其药学上可接受的盐或其水合物等等。
摘要:
An optical spectrum analyzer has a deflection section for changing an incidence angle of measured light on a diffraction grating, a plurality of light detection sections for detecting the dispersed measured light and outputting an electric signal responsive to the light strength, and a signal processing section for finding an optical spectrum of the measured light based on the electric signal from the light detection sections. The light detection sections are arranged along the wavelength dispersion direction of the diffraction grating and output electric signals independently of each other.
摘要:
One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases, inhibiting a Group II metabotropic glutamate receptor. The object is solved by a 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by formula [I]: (wherein R1 and R2 are the same or different, and each represents a hydrogen atom, C1-10alkyl group, etc; X represents a hydrogen atom or a fluorine atom; and Y represents an amino group, —SR3, —S(O)nR7, —SCHR3R4, —S(O)nCHR3R4, —NHCHR3R4, —N(CHR3R4)(CHR5R6), —NHCOR3 or —OCOR7), a pharmaceutically acceptable salt thereof, or a hydrate thereof and so on.
摘要翻译:本发明的一个目的是提供一种有效治疗和预防精神疾病以及治疗和预防神经系统疾病,抑制II族代谢型谷氨酸受体的药物。 该目的通过由式[I]表示的2-氨基 - 双环[3.1.0]己烷-2,6-二羧酸衍生物来解决:(其中R 1和R 2) / SUP>相同或不同,各自表示氢原子,C 1-10烷基等; X表示氢原子或氟原子; Y表示氨基, - S 3 O 3,-S(O)n R 7,-SCHR 3,R 4, (S) - (O)n - , - CHR 3 - - - - - - SO 4 - , - -N(CHR 3 S 4)4(CHR 5 S 6),-NHCOR 其药学上可接受的盐或其水合物等等。
摘要:
This invention is intended to provide an HBT capable of achieving, if the HBT is a collector-up HBT, the constriction of the emitter layer disposed directly under an external base layer, and reduction in base-emitter junction capacity, or if the HBT is an emitter-up HBT, reduction in base-collector junction capacity. For the collector-up HBT, window structures around the sidewalls of a collector are used to etch either the emitter layer disposed directly under the external base layer, or an emitter contact layer For the emitter-up HBT, window structures around the sidewalls of an emitter are used to etch either the collector layer disposed directly under the external base layer, or a collector contact layer. In both HBTs, the external base layer is supported by a columnar structure to ensure mechanical strength.
摘要:
In a fuel injection apparatus 1, a fuel injection rate from which is controlled by a fuel pressure, a branch pipe 11 comprising a tubular member with the tip end closed is provided between a second pressure control valve 9 and a second pressure sensor 10. The branch pipe 11 extends in a direction along a flow direction of the fuel just before the branch pipe 11, and has a capacity not less than one fifth of that of a fuel flow path 22 between the second pressure control valve 9 and a fuel chamber 17. When a pressure difference in the pressure control valve 9 becomes larger and vibration of the fuel pressure is generated, the branch pipe 11 absorbs and reduces the vibration. As the vibration of the fuel pressure is reduced, a stable fuel injection rate is realized.
摘要:
When converting a sequential execution source program into a parallel program to be executed by respective processors (nodes) of a distributed shared memory parallel computer, a compiler computer transforms the source program to increase a processing speed of the parallel program. First, a kernel loop having a longest sequential execution time is detected in the source program. Next, a data access pattern equal to that of the kernel loop is reproduced to generate a control code to control first touch data distribution. The first touch control code generated is inserted in the parallel program.
摘要:
An oil free screw compressor includes a low-pressure stage compressor body and a high-pressure stage compressor body. Power of a motor driven by an inverter is transmitted to the compressor bodies through gears. A low-pressure stage blow-off two-way valve is provided in a pipe branching off midway an air pipe connecting between the high-pressure stage compressor body and the low-pressure stage compressor body, and a high-pressure stage blow-off two-way valve is provided in a pipe branching off from a discharge air pipe provided on a discharge side of the high-pressure stage compressor body. During no-load operation, a controller gives a command to the inverter to make the rotational speed of the motor a set lower limit rotational speed, and also gives an open command to the low-pressure stage blow-off two-way valve.
摘要:
In a capacity control method for an oil-free screw compressor, when an air consumption is larger than a set amount, a rotation frequency of a motor using an inverter to drive the compressor is set to be variable. When the air consumption is a set air amount or less, the inverter is controlled in such a manner that the rotation frequency of the motor is kept at a constant value. In this state, when an operation gas pressure of the compressor reaches an upper-limit value, an air release valve is opened to discharge the operation gas to the atmosphere. Additionally, the rotation frequency of the motor is lowered to a lower-limit value. Re-compression in the compressor can be prevented, and a compressor drive torque is lowered.