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    Approach for assembling and repairing probe assemblies using laser welding
    53.
    发明授权
    Approach for assembling and repairing probe assemblies using laser welding 有权
    使用激光焊接组装和修复探头组件的方法

    公开(公告)号：US08299394B2

    公开(公告)日：2012-10-30

    申请号：US11818851

    申请日：2007-06-15

    申请人： Senthil Theppakuttai ,  Peter J. Klaerner ,  Jason Bradach ,  Mark Cunningham ,  Bahadir Tunaboylu

    发明人： Senthil Theppakuttai ,  Peter J. Klaerner ,  Jason Bradach ,  Mark Cunningham ,  Bahadir Tunaboylu

    IPC分类号： B23K26/00

    CPC分类号： G01R3/00 ,  G01R1/07342 ,  H05K3/328

    摘要： An approach for assembling and repairing probe assemblies using laser welding includes aligning a beam element to a post element on a probe substrate. The beam element is positioned in contact with the post element on the probe substrate. The beam element is then attached to the post element on the probe substrate by laser welding the beam element to the post element on the probe substrate. The approach may include the use of a vacuum capillary pickup tool to align and position the beam element. The vacuum capillary pickup tool may also operate in conjunction with a laser beam delivery system for guiding the laser beam to the correct location for welding and also to assist in removing gases and debris attributable to the laser welding process. The approach allows probe elements to be connected directly to a probe substrate without requiring an intermediate layer.

    摘要翻译： 使用激光焊接组装和修复探针组件的方法包括将束元件对准探针衬底上的柱元件。 梁元件定位成与探针基板上的柱元件接触。 然后通过将束元件通过激光焊接到探针基板上的柱元件将束元件附接到探针基板上的柱元件。 该方法可以包括使用真空毛细管拾取工具来对准和定位束元件。 真空毛细管拾取工具还可以与用于将激光束引导到用于焊接的正确位置的激光束传送系统一起操作，并且还帮助去除归因于激光焊接过程的气体和碎屑。 该方法允许探针元件直接连接到探针衬底而不需要中间层。

    Approach for fabricating cantilever probes for probe card assemblies
    55.
    发明授权
    Approach for fabricating cantilever probes for probe card assemblies 有权
    用于制造探针卡组件的悬臂探头的方法

    公开(公告)号：US07637007B2

    公开(公告)日：2009-12-29

    申请号：US11704050

    申请日：2007-02-07

    申请人： Bahadir Tunaboylu ,  Horst Clauberg ,  Mark Cunningham ,  Senthil Theppakuttai ,  John McGlory

    发明人： Bahadir Tunaboylu ,  Horst Clauberg ,  Mark Cunningham ,  Senthil Theppakuttai ,  John McGlory

    IPC分类号： H01K3/02 ,  B23P6/00 ,  H01L21/76

    CPC分类号： G01R3/00 ,  B33Y80/00 ,  G01R1/06727 ,  G01R1/07342 ,  Y10T29/49147 ,  Y10T29/49151 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49204 ,  Y10T29/49218

    摘要： An approach for fabricating cantilever probes for a probe card assembly includes forming posts on conductive traces on a substrate. A beam panel having beam elements formed therein is aligned to the substrate so that the beam elements are in contact with the plurality of posts. Each beam element is in contact with a post at a portion of the beam element so that both a first end portion and a second end portion overhang the post element. Each beam element is also attached to the beam panel by the first end portion. The beam elements are bonded to the plurality of posts. The first end portion of each beam element is cut, for example using an electrode, laser ablation or by dicing, to release the beam element from the beam panel. The beam panel is then removed, leaving the beam elements attached to the posts.

    摘要翻译： 用于制造用于探针卡组件的悬臂探针的方法包括在基底上的导电迹线上形成柱。 其中形成有梁元件的梁板与衬底对准，使得梁元件与多个柱接触。 每个梁元件在梁元件的一部分处与柱接触，使得第一端部和第二端部部分都悬置在柱元件上。 每个梁元件也通过第一端部附接到梁板。 梁元件结合到多个柱。 每个光束元件的第一端部例如使用电极，激光烧蚀或通过切割来切割，以将光束元件从光束面板释放。 然后将梁板移除，使梁元件附接到柱上。

    NOVEL RECOMBINANT PROTEINS WITH N-TERMINAL FREE THIOL
    56.
    发明申请
    NOVEL RECOMBINANT PROTEINS WITH N-TERMINAL FREE THIOL 审中-公开
    新型重组蛋白与N-末端免费THIOL

    公开(公告)号：US20090239790A1

    公开(公告)日：2009-09-24

    申请号：US12476268

    申请日：2009-06-02

    申请人： Chadler Pool ,  Juliane Mills ,  Mark Cunningham

    发明人： Chadler Pool ,  Juliane Mills ,  Mark Cunningham

    IPC分类号： A61K38/22 ,  C07K14/61

    CPC分类号： C07K1/1075 ,  C07K1/1077 ,  C07K14/505

    摘要： The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular, the invention relates to erythropoietin conjugate compounds having altered biochemical, physiochemical and pharmacokinetic properties. More particularly, one embodiment of the invention relates to erythropoietin conjugate compounds of the formula: (M)n-X-A-cys-EPO   (I) where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino acid cysteine and occurs at position -1 relative to the amino acid sequence of the erythropoietin moiety; A indicates the structure of the residual moiety used to chemically attach X to the thiol group of -1Cys; X is a water soluble polymer such as a polyalkylene glycol or other polymer; M is an organic molecule (including peptides and proteins) that increases the circulating half-life of the construct; and N is an integer from 0 to 15.

    摘要翻译： 本发明涉及具有N-末端游离硫醇的新型修饰蛋白，其可通过重组方法制备并准备进一步化学衍生化。 特别地，本发明涉及具有改变的生物化学，生理化学和药代动力学性质的红细胞生成素缀合物化合物。 更具体地，本发明的一个实施方案涉及下式的促红细胞生成素缀合物化合物：<？in-line-formula description =“In-line Formulas”end =“lead”→（M）nXA-cys-EPO（I） 其中EPO是选自红细胞生成素或促红细胞生成素变体的红细胞生成素，其具有不同于野生型人EPO的至少一种氨基酸，其中，“=”在线公式“end =”tail“ 或其具有引起骨髓细胞增加红细胞产生的生物学特性的任何药物可接受的衍生物; cys代表氨基酸半胱氨酸并且发生在相对于促红细胞生成素部分的氨基酸序列的位置-1; A表示用于将X化学连接到-1Cys的硫醇基上的残留部分的结构; X是水溶性聚合物，例如聚亚烷基二醇或其它聚合物; M是增加构建体的循环半衰期的有机分子（包括肽和蛋白质） N为0〜15的整数。

    SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION
    57.
    发明申请
    SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION 有权
    用于传送远程存储应用程序和信息的系统和方法

    公开(公告)号：US20090150486A1

    公开(公告)日：2009-06-11

    申请号：US12359403

    申请日：2009-01-26

    申请人： Louis M. Franco ,  Frank Leon Rose ,  Philip S.J. Brittan ,  Mark Cunningham ,  Alex Bulkin ,  Mat Baskin ,  Greg Blonder

    发明人： Louis M. Franco ,  Frank Leon Rose ,  Philip S.J. Brittan ,  Mark Cunningham ,  Alex Bulkin ,  Mat Baskin ,  Greg Blonder

    IPC分类号： G06F15/16

    CPC分类号： H04L67/42 ,  G06F8/60 ,  G06F9/54 ,  H04L29/06 ,  H04L51/06 ,  H04L67/025 ,  H04L67/14 ,  H04L67/34 ,  H04L67/36 ,  H04L69/329

    摘要： A method and system are disclosed for delivering interactive links for presenting applications and second information at a client computer from remote sources in a network-configured computer processing system. In one embodiment, the method includes retrieving over a first communication connection, in response to a request of a client computer, informational content having computer program code embedded therein, and executing the embedded computer program code for establishing a second communication connection to an application server. The method further includes retrieving over the second communication connection first information including presentational information for presenting the application and the second information. The method also includes presenting the application and the second information based upon the presentational information, and storing on the client computer an interactive link for selectively re-establishing the second communication connection to the application server for retrieving the first information and presenting the application and the second information on an as-needed basis. Preferably, the storing of the interactive link includes downloading a graphical representation of the interactive link and storing a file containing information representing an operating environment of the client computer and a network address of the application server.

    摘要翻译： 公开了一种方法和系统，用于在网络配置的计算机处理系统中从远程源提供用于在客户端计算机上呈现应用和第二信息的交互式链接。 在一个实施例中，该方法包括响应于客户端计算机的请求检索第一通信连接，其中嵌入有计算机程序代码的信息内容，以及执行用于建立到应用服务器的第二通信连接的嵌入式计算机程序代码 。 该方法还包括通过第二通信连接检索第一信息，包括用于呈现应用程序的显示信息和第二信息。 该方法还包括基于该展示信息呈现应用程序和第二信息，并在客户端计算机上存储交互式链接，用于选择性地重新建立到应用服务器的第二通信连接，用于检索第一信息并呈现应用程序和 根据需要提供第二个信息。 优选地，交互式链接的存储包括下载交互式链接的图形表示，并且存储包含表示客户端计算机的操作环境的信息的文件和应用服务器的网络地址。

    Network-based TTL counter
    58.
    发明申请
    Network-based TTL counter 审中-公开
    基于网络的TTL计数器

    公开(公告)号：US20060176996A1

    公开(公告)日：2006-08-10

    申请号：US11350717

    申请日：2006-02-08

    申请人： Guy Urbina ,  Mark Cunningham

    发明人： Guy Urbina ,  Mark Cunningham

    IPC分类号： H03K23/66

    CPC分类号： H04L67/125

    摘要： A network-based TTL counter having integrated components for processing TTL counts from sensor input and hosting the count data over a network. The TTL counter includes one or more TTL counters, each capable of receiving sensor input and outputting TTL pulse count data; a network node server for communication with a network as a node of the network and transmitting the count data to the network; one or more micro-controllers for controlling the TTL counter(s) and the network transmission of the count data; and a power source. As such TTL counts performed by the TTL counter may be remotely monitored anywhere over a network.

    摘要翻译： 一个基于网络的TTL计数器，具有集成组件，用于处理来自传感器输入的TTL计数，并通过网络托管计数数据。 TTL计数器包括一个或多个TTL计数器，每个TTL计数器都可以接收传感器输入并输出TTL脉冲计数数据; 网络节点服务器，用于与作为网络的节点的网络通信，并将计数数据发送到网络; 用于控制TTL计数器的一个或多个微控制器和计数数据的网络传输; 和电源。 由TTL计数器执行的TTL计数可以通过网络在任何地方进行远程监控。

    Novel recombinant proteins with N-terminal free thiol
    59.
    发明申请
    Novel recombinant proteins with N-terminal free thiol 审中-公开
    具有N-末端游离硫醇的新型重组蛋白

    公开(公告)号：US20050170457A1

    公开(公告)日：2005-08-04

    申请号：US11021516

    申请日：2004-12-23

    申请人： Chadler Pool ,  Juliane Mills ,  Mark Cunningham

    发明人： Chadler Pool ,  Juliane Mills ,  Mark Cunningham

    IPC分类号： C07H21/04 ,  C07K1/00 ,  C07K1/107 ,  C07K14/505 ,  C12N9/96 ,  C12N15/85 ,  C12P21/02

    CPC分类号： C07K1/1075 ,  C07K1/1077 ,  C07K14/505

    摘要： The present invention relates to novel modified proteins having N-terminal free thiols that can be produced by recombinant methods and are ready for further chemical derivatization. In particular, the invention relates to erythropoietin conjugate compounds having altered biochemical, physiochemical and pharmacokinetic properties. More particularly, one embodiment of the invention relates to erythropoietin conjugate compounds of the formula: (M)n-X-A-cys-EPO   (I) where EPO is an erythropoeitin moiety selected from erythropoietin or an erythropoietin variant having at least one amino acid different from the wild-type human EPO, or any pharmaceutical acceptable derivatives thereof having biological properties of causing bone marrow cells to increase production of red blood cells; cys represents the amino acid cysteine and occurs at position −1 relative to the amino acid sequence of the erythropoietin moiety; A indicates the structure of the residual moiety used to chemically attach X to the thiol group of −1Cys; X is a water soluble polymer such as a polyalkylene glycol or other polymer; M is an organic molecule (including peptides and proteins) that increases the circulating half-life of the construct; and N is an integer from 0 to 15.

    摘要翻译： 本发明涉及具有N-末端游离硫醇的新型修饰蛋白，其可通过重组方法制备并准备进一步化学衍生化。 特别地，本发明涉及具有改变的生物化学，生理化学和药代动力学性质的红细胞生成素缀合物化合物。 更具体地，本发明的一个实施方案涉及下式的促红细胞生成素缀合物化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（M） -XA-cys-EPO（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中EPO是选自促红细胞生成素或具有至少一个氨基酸的促红细胞生成素变体的红细胞生成部分 不同于野生型人EPO，或其具有引起骨髓细胞增加红细胞产生的生物学特性的任何药物可接受的衍生物; cys代表氨基酸半胱氨酸并且发生在相对于促红细胞生成素部分的氨基酸序列的位置-1; A表示用于将X化学连接到-1Cys的硫醇基上的残留部分的结构; X是水溶性聚合物，例如聚亚烷基二醇或其它聚合物; M是增加构建体的循环半衰期的有机分子（包括肽和蛋白质） N为0〜15的整数。