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139 条记录 (耗时 0.028 秒)

    In-situ anionic continuous dispersion polymerization process
    53.
    发明授权
    In-situ anionic continuous dispersion polymerization process 失效
    原位阴离子连续分散聚合方法

    公开(公告)号：US5891947A

    公开(公告)日：1999-04-06

    申请号：US137332

    申请日：1993-10-18

    申请人： James E. Hall ,  David M. Roggeman

    发明人： James E. Hall ,  David M. Roggeman

    IPC分类号： C08F2/44 ,  C08F2/00 ,  C08F212/00 ,  C08F212/06 ,  C08F236/10 ,  C08F297/04 ,  C08K3/20

    CPC分类号： C08F297/04

    摘要： The present invention relates to a process for the dispersion copolymerization of 35 to 70% by weight of vinyl substituted aromatic monomer and 30 to 65% by weight of conjugated diene monomer comprising carrying out the copolymerization in a reaction mixture containing a liquid aliphatic hydrocarbon dispersing medium, an anionic catalyst system, and an "A" block of a copolymer dispersing agent, the dispersing agent having at least two polymer blocks wherein at least one of the polymer blocks is soluble in the dispersing medium and at least another of the polymer blocks is insoluble in the dispersing medium and is formed in situ.

    摘要翻译： 本发明涉及一种将35〜70重量％乙烯基取代芳香族单体和30〜65重量％的共轭二烯单体进行分散共聚的方法，包括在含有液体脂族烃分散介质的反应混合物中进行共聚 ，阴离子催化剂体系和共聚物分散剂的“A”嵌段，所述分散剂具有至少两个聚合物嵌段，其中至少一个聚合物嵌段可溶于分散介质，并且至少另一个聚合物嵌段是 不溶于分散介质并原位形成。

    Benzamidoxime prodrugs as antipneumocystic agents
    54.
    发明授权
    Benzamidoxime prodrugs as antipneumocystic agents 失效
    苯甲酰胺肟前药作为抗肺囊虫药

    公开(公告)号：US5843980A

    公开(公告)日：1998-12-01

    申请号：US751171

    申请日：1996-11-15

    申请人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

    发明人： James E. Hall ,  Richard R. Tidwell ,  David W. Boykin

    IPC分类号： C07D307/52 ,  A61K31/00 ,  A61K31/15 ,  A61K31/155 ,  A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61P11/00 ,  A61P31/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C259/18 ,  C07D235/24 ,  C07D307/54 ,  C07D307/68 ,  C07D333/24 ,  C07D333/20

    CPC分类号： A61K31/15 ,  A61K31/155 ,  A61K31/341 ,  C07C257/18 ,  C07C259/18 ,  C07D307/54 ,  C07D307/68 ,  C07D333/24

    摘要： A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime of Formula II ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl or alkylaminoalkyl; R.sub.3 is H, loweralkyl, oxyalkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, aryl, aminoalkyl, alkylaminoalkyl or halogen; R.sub.4 is --OY, or R.sub.1 and R.sub.4 together represent, ##STR2## wherein R.sub.5 is ##STR3## Y is H or loweralkyl; n is an integer from 0 to 2; and A is a heterocyclic aromatic group selected from the group consisting of: ##STR4## wherein R.sub.6 and R.sub.7 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti-P. carinii activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.

    摘要翻译： 公开了在需要这种治疗的受试者中治疗卡氏肺囊虫肺炎的方法。 该方法包括向受试者口服施用式II的双 - 苯甲脒肟（II），其中：R 1和R 2各自独立地选自H，低级烷基，烷氧基烷基，烷氧基烷基，环烷基，芳基，羟烷基，氨基烷基 或烷基氨基烷基; R3是H，低级烷基，氧烷基，烷氧基烷基，羟基烷基，环烷基，芳基，氨基烷基，烷基氨基烷基或卤素; R 4是-OY，或者R 1和R 4一起表示，其中R 5是H或低级烷基; n为0〜2的整数; 并且A是选自以下的杂环芳族基团：其中R 6和R 7各自独立地选自H，低级烷基，卤素，氧烷基，氧芳基或氧芳基烷基，或其药学上可接受的盐， 在受试者中减少以产生具有抗-P的苄脒。 卡里尼活动。 本发明的方法可以选择性地向受试者静脉内施用本文所公开的活性化合物。 还公开了可用于本发明实践的药物制剂和活性化合物。

    Soluble anionic polymerization initiators and products therefrom
    55.
    发明授权
    Soluble anionic polymerization initiators and products therefrom 失效
    可溶性阴离子聚合引发剂及其产物

    公开(公告)号：US5723533A

    公开(公告)日：1998-03-03

    申请号：US756548

    申请日：1996-11-26

    申请人： David F. Lawson ,  James E. Hall ,  Yoichi Ozawa

    发明人： David F. Lawson ,  James E. Hall ,  Yoichi Ozawa

    IPC分类号： C08F4/48 ,  C07D295/22 ,  C08C19/44 ,  C08F4/00 ,  C08F4/06 ,  C08F4/08 ,  C08F36/04 ,  C08F236/04 ,  C08K3/04

    CPC分类号： C08C19/44 ,  C07D295/22 ,  C08F36/04 ,  Y10T152/10495

    摘要： An acyclic alkane soluble anionic polymerization initiator includes a mixture of from about 90 to about 10 parts by weight of a lithio amine having the general formula A.sub.1 Li and from about 10 to about 90 parts by weight of at least one other lithio amine having the general formula A.sub.2 Li. A.sub.1 and A.sub.2 are selected from the dialkyl, alkyl, cycloalkyl and dicycloalkyl amine radicals and cyclic amine radicals. There is also provided a method of forming a mixture of anionic polymerization initiators, a functionalized polymer and a method of forming a functionalized polymer.

    摘要翻译： 无环烷烃可溶性阴离子聚合引发剂包括约90至约10重量份的具有通式A1Li的锂二胺和约10至约90重量份的至少一种其它具有通式 A2Li。 A1和A2选自二烷基，烷基，环烷基和二环烷基胺基和环胺基。 还提供了形成阴离子聚合引发剂，官能化聚合物和形成官能化聚合物的方法的混合物的方法。

    Anionic polymerization initiators containing adducts of cyclic secondary amines and conjugated dienes, and products therefrom
    57.
    发明授权
    Anionic polymerization initiators containing adducts of cyclic secondary amines and conjugated dienes, and products therefrom 失效
    含有环状仲胺和共轭二烯的加合物的阴离子聚合引发剂及其产物

    公开(公告)号：US5610228A

    公开(公告)日：1997-03-11

    申请号：US471276

    申请日：1995-06-06

    申请人： David F. Lawson ,  Thomas A. Antkowiak ,  James E. Hall ,  Mark L. Stayer, Jr.

    发明人： David F. Lawson ,  Thomas A. Antkowiak ,  James E. Hall ,  Mark L. Stayer, Jr.

    IPC分类号： C08F4/08 ,  C07F1/02 ,  C08F4/42 ,  C08F4/46 ,  C08F4/48 ,  C08F236/04 ,  C08F236/10 ,  C08K5/01

    CPC分类号： C07F1/02

    摘要： An anionic polymerization initiator includes a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene. A method of preparing an anionic polymerization initiator includes reacting an excess of a cyclic secondary amine with a conjugated diene to form an adduct; and, reacting the adduct with an organolithium compound. A method of preparing a polymer includes forming a solution of one or more anionically polymerizable monomers in a hydrocarbon solvent; and, polymerizing the monomer with an anionic polymerization initiator comprising a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene. A functionalized polymer includes the termination product of a living polymer having the general formula AYLi, wherein A is a functional group derived from an anionic polymerization initiator; and, Y is a divalent polymer radical; wherein the anionic polymerization initiator is a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene.

    摘要翻译： 阴离子聚合引发剂包括环状仲胺与共轭二烯的加合物的碳 - 硫酸盐。 制备阴离子聚合引发剂的方法包括使过量的环状仲胺与共轭二烯反应形成加合物; 并使加合物与有机锂化合物反应。 制备聚合物的方法包括在烃溶剂中形成一种或多种阴离子聚合单体的溶液; 并且用包含环状仲胺加成物的碳 - 硫醇盐与共轭二烯的阴离子聚合引发剂聚合单体。 官能化聚合物包括具有通式AYLi的活性聚合物的终止产物，其中A是衍生自阴离子聚合引发剂的官能团; Y为二价聚合物基团; 其中所述阴离子聚合引发剂是环状仲胺与共轭二烯的加合物的碳 - 锂盐。

    Anionic polymerization initiators containing adducts of cyclic secondary amines and conjugated dienes, and products therefrom
    58.
    发明授权
    Anionic polymerization initiators containing adducts of cyclic secondary amines and conjugated dienes, and products therefrom 失效
    含有环状仲胺和共轭二烯的加合物的阴离子聚合引发剂及其产物

    公开(公告)号：US5502130A

    公开(公告)日：1996-03-26

    申请号：US469131

    申请日：1995-06-06

    申请人： David F. Lawson ,  Thomas A. Antkowiak ,  James E. Hall ,  Mark L. Stayer, Jr.

    发明人： David F. Lawson ,  Thomas A. Antkowiak ,  James E. Hall ,  Mark L. Stayer, Jr.

    IPC分类号： C08F4/08 ,  C07F1/02 ,  C08F4/42 ,  C08F4/46 ,  C08F4/48 ,  C08F236/04 ,  C08F236/10

    CPC分类号： C07F1/02

    摘要： An anionic polymerization initiator includes a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene. A method of preparing an anionic polymerization initiator includes reacting an excess of a cyclic secondary amine with a conjugated diene to form an adduct; and, reacting the adduct with an organolithium compound. A method of preparing a polymer includes forming a solution of one or more anionically polymerizable monomers in a hydrocarbon solvent; and, polymerizing the monomer with an anionic polymerization initiator comprising a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene. A functionalized polymer includes the termination product of a living polymer having the general formula AYLi, Wherein A is a functional group derived from an anionic polymerization initiator; and, Y is a divalent polymer radical; wherein the anionic polymerization initiator is a carbon-lithio salt of the adduct of a cyclic secondary amine with a conjugated diene.

    摘要翻译： 阴离子聚合引发剂包括环状仲胺与共轭二烯的加合物的碳 - 硫酸盐。 制备阴离子聚合引发剂的方法包括使过量的环状仲胺与共轭二烯反应形成加合物; 并使加合物与有机锂化合物反应。 制备聚合物的方法包括在烃溶剂中形成一种或多种阴离子聚合单体的溶液; 并且用包含环状仲胺加成物的碳 - 硫醇盐与共轭二烯的阴离子聚合引发剂聚合单体。 官能化聚合物包括具有通式AYLi的活性聚合物的终止产物，其中A是衍生自阴离子聚合引发剂的官能团; Y为二价聚合物基团; 其中所述阴离子聚合引发剂是环状仲胺与共轭二烯的加合物的碳 - 锂盐。

    Process for the preparation of in situ dispersion of copolymers
    59.
    发明授权
    Process for the preparation of in situ dispersion of copolymers 失效
    制备共聚物原位分散体的方法

    公开(公告)号：US5331035A

    公开(公告)日：1994-07-19

    申请号：US995118

    申请日：1992-12-22

    申请人： James E. Hall

    发明人： James E. Hall

    IPC分类号： C08F2/44 ,  C08F212/00 ,  C08F212/06 ,  C08F236/10 ,  C08F297/04 ,  C08K3/02

    CPC分类号： C08F297/04

    摘要： The present invention relates to a process for the dispersion copolymerization of 35 to 70% by weight of vinyl substituted aromatic monomer and 30 to 65% by weight of conjugated diene monomer comprising carrying out the copolymerization in a reaction mixture containing a liquid aliphatic hydrocarbon dispersing medium, an anionic catalyst system, and an "A" block of a copolymer dispersing agent, the dispersing agent having at least two polymer blocks wherein at least one of the polymer blocks is soluble in the dispersing medium and at least another of the polymer blocks is insoluble in the dispersing medium and is formed in situ.

    摘要翻译： 本发明涉及一种将35〜70重量％乙烯基取代芳香族单体和30〜65重量％的共轭二烯单体进行分散共聚的方法，包括在含有液体脂族烃分散介质的反应混合物中进行共聚 ，阴离子催化剂体系和共聚物分散剂的“A”嵌段，所述分散剂具有至少两个聚合物嵌段，其中至少一个聚合物嵌段可溶于分散介质，并且至少另一个聚合物嵌段是 不溶于分散介质并原位形成。

    (Halomethyl vinyl arene)-modified elastomers and compositions containing them having reduced hysteresis properties
    60.
    发明授权
    (Halomethyl vinyl arene)-modified elastomers and compositions containing them having reduced hysteresis properties 失效
    （卤代甲基乙烯基芳烃）改性的弹性体和含有它们的具有降低的滞后性质的组合物

    公开(公告)号：US5317057A

    公开(公告)日：1994-05-31

    申请号：US998204

    申请日：1992-12-30

    申请人： James E. Hall ,  William L. Hergenrother ,  James Oziomek

    发明人： James E. Hall ,  William L. Hergenrother ,  James Oziomek

    IPC分类号： B60C1/00 ,  C08C19/44 ,  C08L9/06 ,  C08L9/00 ,  C08L11/00

    CPC分类号： C08C19/44 ,  B60C1/0016

    摘要： A (halomethyl arene)-modified elastomer is made by reacting a lithium terminated elastomer intermediate with the halogen atoms of a halomethyl vinyl arene compound. A road-contacting tread component for a pneumatic tire is fabricated from vulcanized elastomer made by vulcanizing an elastomer composition of a (halomethyl arene)-modified elastomer, a carbon black reinforcing agent, and a sulfur-based vulcanizing system. A process for making a (halomethyl arene)-modified elastomer includes polymerizing at least one diene monomer with a lithium-containing initiator, capping the lithium terminated elastomer by reaction with a halomethyl arene compound, and recovering the modified elastomer.

    摘要翻译： 通过使锂封端的弹性体中间体与卤代甲基乙烯基芳烃化合物的卤素原子反应制备（卤代甲基芳烃） - 改性的弹性体。 用于充气轮胎的道路接触胎面部件由通过硫化（卤代甲基芳烃）改性弹性体，炭黑增强剂和硫基硫化体系的弹性体组合物制成的硫化弹性体制成。 制备（卤代甲基芳烃）改性弹性体的方法包括使含有锂的引发剂使至少一种二烯单体聚合，通过与卤代甲基芳烃化合物的反应来封端锂封端的弹性体，并回收改性弹性体。