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公开(公告)号：US20120031830A1
公开(公告)日：2012-02-09
申请号：US13127921
申请日：2009-11-09
申请人： David A. Edwards , Joseph Shivers , Kevin Burrows , Steve Teng , Michael Silvestri , Werner Hugo van Vuuren , Mathieu Lehanneur , Jose Sanchez
发明人： David A. Edwards , Joseph Shivers , Kevin Burrows , Steve Teng , Michael Silvestri , Werner Hugo van Vuuren , Mathieu Lehanneur , Jose Sanchez
摘要： Water can be transported and/or treated using a system or container in which a collapsible framework is attached to a membrane. A collapsible water container defining a volume for receiving, transporting, and delivering water can include: a membrane of material substantially impermeable to water, the membrane having a substantially cylindrical expanded configuration with a central axis and substantially contracted configuration; wherein the membrane configured to rotatably expand about the axis when water is placed within the volume defined by the collapsible water container and rotatably contract about the axis when water is removed from the volume defined by the collapsible water container.
摘要翻译： 水可以使用其中可折叠框架附接到膜的系统或容器来运输和/或处理水。 限定用于接收，运输和输送水的体积的可折叠的水容器可以包括：基本上不透水的材料膜，所述膜具有基本上圆柱形的膨胀构型，具有中心轴线和基本上收缩的构型; 其中所述膜构造成当水被放置在由所述可折叠的水容器限定的体积内时围绕所述轴线可旋转地膨胀，并且当水从所述可折叠的水容器限定的体积中移除时，所述膜可绕所述轴线旋转收缩。
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公开(公告)号：US20120017011A1
公开(公告)日：2012-01-19
申请号：US12836341
申请日：2010-07-14
IPC分类号： G06F3/00
CPC分类号： G06F3/0604 , G06F3/0617 , G06F3/0659 , G06F3/067
摘要： A method, apparatus, system, and computer program product for enabling out-of-band access to storage devices through port-sharing hardware. Providing out-of-band access to storage devices enables system management functions to be performed when an operating system is non-functional as well as when the operating system is active. Storage commands originating with a management service can be interleaved with storage commands issued by the host operating system. The host operating system maintains ownership and control over its storage devices, but management activities can be performed while the host operating system is operational.
摘要翻译： 一种用于通过端口共享硬件对存储设备进行带外访问的方法，装置，系统和计算机程序产品。 提供对存储设备的带外访问可使系统管理功能在操作系统不起作用以及操作系统处于活动状态时执行。 源自管理服务的存储命令可以与主机操作系统发出的存储命令交错。 主机操作系统维护对其存储设备的所有权和控制权，但是可以在主机操作系统运行时执行管理活动。
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公开(公告)号：USD631538S1
公开(公告)日：2011-01-25
申请号：US29334903
申请日：2009-04-03
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公开(公告)号：US07698884B2
公开(公告)日：2010-04-20
申请号：US12222551
申请日：2008-08-12
申请人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
发明人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
摘要： A power transmission arrangement comprises a first power transmission member connectable to a first main shaft of an engine. The arrangement also includes a second power transmission member connectable to a second main shaft of the engine and to a third power transmission member. A coupling assembly is provided which has a selectable coupling condition to couple the first power transmission member to the second power transmission member to allow power to be transmitted from the third power transmission member to the first main shaft of the engine via the first power transmission member. The coupling assembly has a decoupling condition to decouple the first power transmission member from the second power transmission member to allow power to be transmitted from the main shaft of the engine to the third power transmission member via the second power transmission member.
摘要翻译： 动力传递装置包括可连接到发动机的第一主轴的第一动力传递构件。 该装置还包括可连接到发动机的第二主轴和第三动力传递构件的第二动力传递构件。 提供了一种联接组件，其具有可选择的联接状态，以将第一动力传递构件联接到第二动力传递构件，以允许动力经由第一动力传递构件从第三动力传递构件传递到发动机的第一主轴 。 联接组件具有去耦条件，以将第一动力传递构件与第二动力传递构件分离，以允许动力经由第二动力传递构件从发动机的主轴传递到第三动力传递构件。
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公开(公告)号：US20090208581A1
公开(公告)日：2009-08-20
申请号：US12351328
申请日：2009-01-09
申请人： David A. Edwards , Howard A. Stone
发明人： David A. Edwards , Howard A. Stone
IPC分类号： A61K9/14 , C08B37/00 , C07K14/00 , A61K31/74 , A61K38/16 , A61K31/715 , C08B37/02 , C08G65/34 , C07K14/76 , A61K31/721 , A61K31/765 , A61K38/38 , A61P31/12 , A01K29/00 , A61D7/00
CPC分类号： A61K9/0075 , A61K9/0078 , A61K31/355 , A61K31/685 , A61K31/715
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译： 已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。 用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。 制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。 载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。 这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。 药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。 这些可以与制剂一起施用或掺入制剂中。
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公开(公告)号：US20080213373A1
公开(公告)日：2008-09-04
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译： 已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘 。 制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。 通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。 在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。 在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。 任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。 制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。 制剂优选作为肺制剂施用。 在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。 在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。
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公开(公告)号：US07048908B2
公开(公告)日：2006-05-23
申请号：US10202616
申请日：2002-07-23
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
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公开(公告)号：US06921528B2
公开(公告)日：2005-07-26
申请号：US10681416
申请日：2003-10-08
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K31/198 , A61K31/46 , A61K31/56 , A61K38/27 , A61K38/28 , A61K39/395 , A61L9/04 , B05D7/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
摘要翻译： 在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒 超过0.4g / cm 3，并输送至少约50％的质量的颗粒。 在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。 容器可具有至少0.37厘米3的体积。
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59.发明授权Methods of reliably allocating, de-allocating, re-allocating, and reclaiming objects in a symmetrically blocked nonvolatile memory having a bifurcated storage architecture 失效在具有分叉存储架构的对称封锁非易失性存储器中可靠地分配，分配，重新分配和回收对象的方法公开(公告)号：US06311290B1
公开(公告)日：2001-10-30
申请号：US09055032
申请日：1998-04-03
IPC分类号： H02H305
CPC分类号： G06F12/0246 , G06F11/0793 , G06F2212/7205 , Y10S707/99953
摘要： Methods of reliably allocating, writing, reading, de-allocating, re-allocating, and reclaiming space within a nonvolatile memory having a bifurcated storage architecture are described. Allocation, writing, reading, de-allocating, re-allocating, and reclamation are handled by a memory manager. The memory manager tracks the progress of each process during execution in order to detect whether a selected process was interrupted for purposes of recovery. The nonvolatile memory is recovered to a known state during initialization. Initialization includes the step of determining a recovery state from a recovery state lookup table. A selected recovery process is selected in accordance with the recovery state lookup table. A restart level for the selected process is determined from a corresponding restart state lookup table. The selected process is then restarted at the restart level. In one embodiment, a method of managing a nonvolatile memory includes the step of identifying an interrupted process from at least one of an allocation, a reclamation, a configuration header reclaim, and a re-allocation process initiated on the nonvolatile memory. A recovery process is selected for the interrupted process. An entry point into the recovery process is determined. The selected recovery process is then restarted at the entry point.
摘要翻译： 描述了在具有分叉存储结构的非易失性存储器内可靠地分配，写入，读取，分配，重新分配和回收空间的方法。 分配，写入，读取，取消分配，重新分配和回收由内存管理员处理。 内存管理器在执行期间跟踪每个进程的进度，以便检测所选进程是否为了恢复目的而中断。 在初始化期间，非易失性存储器恢复到已知状态。 初始化包括从恢复状态查找表确定恢复状态的步骤。 根据恢复状态查找表选择选择的恢复过程。 从相应的重新启动状态查找表确定所选进程的重新启动级别。 然后在重新启动级别重新启动所选进程。 在一个实施例中，管理非易失性存储器的方法包括从在非易失性存储器上发起的分配，回收，配置报头回收和重新分配过程中的至少一个识别中断的进程的步骤。 为中断的进程选择恢复过程。 确定恢复过程的入口点。 然后在入口点重新启动所选的恢复过程。
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60.发明授权Method and apparatus for executing a program stored in nonvolatile memory 失效用于执行存储在非易失性存储器中的程序的方法和装置公开(公告)号：US06243789B1
公开(公告)日：2001-06-05
申请号：US09028159
申请日：1998-02-23
申请人： Robert N. Hasbun , David A. Edwards
发明人： Robert N. Hasbun , David A. Edwards
IPC分类号： G06F1208
CPC分类号： G06F9/3812 , G06F12/0292 , G06F12/0638 , G06F2212/2022
摘要： A method of executing a program includes the step of initiating execution of the program stored contiguously without code fragmentation in a nonvolatile memory. Execution of the program is halted if the program attempts to modify a page of the nonvolatile memory. The page of nonvolatile memory is then copied to a modifiable memory. The page of nonvolatile memory is then remapped to the modifiable memory. Execution of the program is then resumed. A computer system for execution of a program includes a nonvolatile memory storing a program contiguously without code fragmentation. The computer system includes a processor for executing the program. A memory management unit generates an interrupt in response to a request to modify a page of the nonvolatile memory. Execution of the program is halted and the processor copies the page of nonvolatile memory to a modifiable memory in response to the interrupt. The processor resumes execution of the program after updating an address translation table of the memory management unit to refer to the modifiable memory for subsequent program access requests to the page of nonvolatile memory.
摘要翻译： 执行程序的方法包括在非易失性存储器中开始执行连续存储的程序而没有代码碎片的步骤。 如果程序尝试修改非易失性存储器的页面，程序的执行将停止。 然后将非易失性存储器的页面复制到可修改的存储器。 然后将非易失性存储器的页面重新映射到可修改的存储器。 然后，程序的执行恢复。 用于执行程序的计算机系统包括非易失性存储器，其连续地存储程序而没有代码分段。 计算机系统包括用于执行程序的处理器。 存储器管理单元响应于修改非易失性存储器的页面的请求而产生中断。 停止执行程序，并且处理器将非易失性存储器的页面复制到可修改的存储器以响应中断。 在更新存储器管理单元的地址转换表之后，处理器恢复执行该程序，以引用可修改的存储器，以便随后的程序访问请求到非易失性存储器的页面。
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