利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

149 条记录 (耗时 0.047 秒)

    Devices and methods for removing pathogens from biological fluids
    51.
    发明授权
    Devices and methods for removing pathogens from biological fluids 有权
    用于从生物流体中除去病原体的装置和方法

    公开(公告)号：US06270672B1

    公开(公告)日：2001-08-07

    申请号：US09369692

    申请日：1999-08-06

    申请人： Peter Turecek ,  Erwin Mattes ,  Hans Peter Schwarz

    发明人： Peter Turecek ,  Erwin Mattes ,  Hans Peter Schwarz

    IPC分类号： B01D6114

    CPC分类号： B01D61/425 ,  A61L2/0011 ,  A61L2/0017 ,  B01D57/02

    摘要： A method for removing pathogens from biological liquids and an apparatus for performing such a method, said method comprising the steps of providing a biological liquid, wherein pathogens are potentially present, in an apparatus comprising an anode and a kathode and a separation means suitable for separating said pathogens from said pharmaceutically active molecule, said separation means being positioned between said anode and said kathode, applying current between said anode and said kathode, thereby causing one of said pathogens or said pharmaceutically active molecule to pass said separation means and recovering said pharmaceutically active molecule in a form being free of said pathogens as well as an apparatus carrying out the present method.

    摘要翻译： 一种用于从生物液体中除去病原体的方法和用于进行这种方法的装置，所述方法包括以下步骤：在包含阳极和阴极的设备中提供其中潜在存在病原体的生物液体，以及适于分离所述 来自所述药物活性分子的病原体，所述分离装置位于所述阳极和所述阴极之间，在所述阳极和所述阴极之间施加电流，从而使所述病原体或所述药物活性分子之一通过所述分离装置并将所述药物活性分子 没有所述病原体的形式以及实施本方法的装置。

    Virus-inactivated factor Xa preparation
    54.
    发明授权
    Virus-inactivated factor Xa preparation 失效
    病毒灭活因子Xa制备

    公开(公告)号：US5593968A

    公开(公告)日：1997-01-14

    申请号：US285040

    申请日：1994-08-02

    申请人： Peter Turecek ,  Eibl Johann ,  Hans-Peter Schwarz

    发明人： Peter Turecek ,  Eibl Johann ,  Hans-Peter Schwarz

    IPC分类号： A61K38/43 ,  A61K38/00 ,  A61P7/00 ,  C12N9/64 ,  A61K38/36 ,  A61K35/16 ,  C07K1/16 ,  C07K14/745

    CPC分类号： C12N9/6432 ,  C12Y304/21006 ,  A61K38/00 ,  Y10S514/834 ,  Y10S530/829 ,  Y10S530/83

    摘要： A virus-inactivated Factor-Xa preparation with at least 100 units coagulation factor activity per mg protein is described, wherein this preparation is produced by activation of a corresponding starting material and subsequent treatment for the inactivation of infectious agents, particularly viruses. By incubation, the preparation obtained in this manner is transformed into a stable beta-Factor Xa preparation. In addition, the use of the present preparation for the treatment of hemophilia A inhibitor patients is disclosed.

    摘要翻译： 描述了具有至少100单位凝血因子活性/ mg蛋白质的病毒灭活因子-Xa制剂，其中该制剂通过活化相应的起始物质和随后的感染因子，特别是病毒灭活的处理而产生。 通过孵育，将以这种方式获得的制剂转化成稳定的β因子Xa制剂。 此外，公开了本发明制剂用于治疗血友病A抑制剂患者的用途。

    Method for the purification of alpha-1 proteinase inhibitor (a1PI)
    59.
    发明授权
    Method for the purification of alpha-1 proteinase inhibitor (a1PI) 有权
    纯化α-1蛋白酶抑制剂（a1PI）的方法

    公开(公告)号：US07807435B2

    公开(公告)日：2010-10-05

    申请号：US11202349

    申请日：2005-08-11

    申请人： Peter Matthiessen ,  Gerald Brachtl ,  Peter Turecek ,  Hans-Peter Schwarz

    发明人： Peter Matthiessen ,  Gerald Brachtl ,  Peter Turecek ,  Hans-Peter Schwarz

    IPC分类号： C12N9/99

    CPC分类号： C07K14/8125

    摘要： The present invention relates to a method for the purification of alpha-1 proteinase inhibitor (a1PI) from protein fractions. More specifically, the invention relates to an improved method for the purification of alpha-1 proteinase inhibitor (a1PI), wherein the yield of a1PI can be increased by thawing the starting material and incubating it for several hours before subjecting it to a washing step.

    摘要翻译： 本发明涉及从蛋白质级分纯化α-1蛋白酶抑制剂（a1PI）的方法。 更具体地说，本发明涉及一种纯化α-1蛋白酶抑制剂（a1PI）的改进方法，其中可以通过解冻起始物质并将其孵育数小时，然后使其进行洗涤步骤，从而增加a1PI的产率。