公开(公告)号：US20150335343A1

公开(公告)日：2015-11-26

申请号：US14705494

申请日：2015-05-06

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Nora Catherine Hogan ,  Ashley A. Brown

IPC: A61B17/3203

CPC classification number: A61B17/3203 ,  A61B17/22 ,  A61B17/32037 ,  A61B17/32093 ,  A61B2017/00026 ,  A61B2017/00039 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/00761 ,  A61B2017/22079 ,  A61B2017/22082 ,  A61M1/0084 ,  A61M1/0088 ,  A61M2205/05

Abstract: A debridement device having a controllable Lorentz-force actuator is disclosed. The debridement device includes a nozzle delivering a jet of debridement substance to a tissue and the jet is driven by the Lorentz-force actuator. The device may have a suction port for removing the debridement substance. A second Lorentz-force actuator can be used for each of the jet and suction. The first and second Lorentz-force actuators for the jet and suction can also be configured to provide for continuous jet injection and continuous suction. The device may include a second nozzle delivering a second jet of debridement substance to the region of tissue and the first and second jets may intersect and dissipate into a mist upon intersection to dissipate the kinetic energy of the jets. The Lorentz-force actuator may drive a reciprocating piston pump providing continuous pressure to the nozzles.

Abstract translation: 公开了具有可控的洛伦兹力致动器的清创装置。 清创装置包括向组织输送清创物质的射流的喷嘴，并且射流由洛伦兹力致动器驱动。 该装置可以具有用于去除清创物质的吸入口。 第二个洛仑兹力致动器可以用于每个射流和吸力。 用于喷射和抽吸的第一和第二洛伦兹力致动器还可以被配置为提供连续喷射和连续抽吸。 该装置可以包括将清创物质的第二射流输送到组织区域的第二喷嘴，并且第一和第二射流可在相交处相交并消散成雾状物以消散射流的动能。 洛伦兹力致动器可以驱动向喷嘴提供连续压力的往复活塞泵。

公开(公告)号：US20150313798A1

公开(公告)日：2015-11-05

申请号：US14699846

申请日：2015-04-29

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Ashin P. Modak ,  Nora Catherine Hogan

IPC: A61J1/20 ,  A61J1/14

CPC classification number: A61J1/2044 ,  A61J1/14 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096

Abstract: A needle-free adaptor for removing liquid from a vial comprises a cannula adapted to piece a septum of a vial, a plurality of legs surrounding the cannula to secure the adaptor to the vial when the cannula has pieced the septum, an elastomeric membrane having a normally closed pinhole orifice, and a conforming surface having an orifice connected to the cannula. The elastomeric membrane has a stable convex shape and is adapted to receive a nozzle of a needle-free device. Pressed against the elastomeric membrane, the nozzle deflects the elastomeric membrane from the convex shape to an unstable or pseudo-stable inverted position against the conforming surface. Buckling of the elastomeric membrane opens the pinhole orifice and enables fluid communication between the vial and the nozzle by interfacing the pinhole orifice with the orifice on the conforming surface.

Abstract translation: 用于从小瓶中去除液体的无针适配器包括适于分隔小瓶的隔膜的套管，围绕套管的多个腿部，以在套管接合隔膜时将适配器固定到小瓶;弹性膜，其具有 常闭针孔，以及具有连接到插管的孔的适形表面。 弹性体膜具有稳定的凸形形状并且适于接收无针装置的喷嘴。 针对弹性体膜，喷嘴将弹性体膜从凸形偏转到不稳定或假稳定的倒置位置以抵抗合体表面。 弹性膜的弯曲打开针孔，并通过将针孔与接合表面上的孔接口，使小瓶和喷嘴之间的流体连通。

公开(公告)号：US20150025505A1

公开(公告)日：2015-01-22

申请号：US14504903

申请日：2014-10-02

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Andrew J. Taberner ,  N. Catherine Hogan

IPC: A61M5/30 ,  A61M5/19

CPC classification number: A61M5/30 ,  A61B10/0045 ,  A61B10/02 ,  A61B10/0283 ,  A61B2010/008 ,  A61M5/19 ,  A61M2005/3128 ,  A61M2205/8287

Abstract: The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Abstract translation: 本发明涉及一种用于即时混合固体或粉末制剂及其后续递送至生物体的方法和相应装置。 在一些实施方案中，将粉末制剂保持在多个室的第一室中。 多个电磁致动器与多个室连通。 致动器在被激活时在至少第一室内产生压力。 压力导致粉末制剂和稀释剂及时混合以输送到生物体中。

公开(公告)号：US20150005701A1

公开(公告)日：2015-01-01

申请号：US14490126

申请日：2014-09-18

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Andrew J. Taberner ,  Brian D. Hemond ,  Dawn M. Wendell ,  Nora Catherine Hogan ,  Nathan B. Ball

IPC: A61M5/30 ,  A61D7/00

CPC classification number: H02K41/02 ,  A61B17/20 ,  A61B17/205 ,  A61D7/00 ,  A61M5/19 ,  A61M5/30 ,  A61M2205/50 ,  A61M2205/6009 ,  A61M2205/825 ,  A61M2250/00

Abstract: A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

Abstract translation: 用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。 称为洛伦兹力致动器的致动器包括固定磁体组件和动圈组件。 线圈组件移动具有位于储存器内的端部的活塞。 致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。 力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。 有利地，致动器可以根据电气输入沿不同方向移动。

公开(公告)号：US20130197162A1

公开(公告)日：2013-08-01

申请号：US13766257

申请日：2013-02-13

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Lauren Montemayor ,  Eli Travis Paster ,  Priam Pillai

IPC: H01B1/12

CPC classification number: H01B1/127 ,  H01B1/12

Abstract: Method for connecting two portions of a first electrically conducting polymer with a second polymer. The method includes disposing a solution of a second polymer in a solvent to be in contact with the two portions of the first electrically conducting polymer and allowing the solvent to evaporate leaving the second polymer joining the two portions of the first polymer. The second polymer may be doped to improve its conductivity.

Abstract translation: 将第一导电聚合物的两部分与第二聚合物连接的方法。 该方法包括将第二聚合物的溶液设置在溶剂中以与第一导电聚合物的两个部分接触并允许溶剂蒸发，留下连接第一聚合物两部分的第二聚合物。 可以掺杂第二聚合物以改善其导电性。