公开(公告)号：US09797248B2

公开(公告)日：2017-10-24

申请号：US14126289

申请日：2011-06-13

申请人： Manchao He ,  Zhigang Tao ,  Bin Zhang ,  Xiaojie Yang

发明人： Manchao He ,  Zhigang Tao ,  Bin Zhang ,  Xiaojie Yang

IPC分类号： E21D21/00 ,  E21D20/02 ,  E02D5/80 ,  E21D21/02

CPC分类号： E21D21/0033 ,  E02D5/80 ,  E21D21/02

摘要： A constant-resistance and large deformation anchor cable and a constant-resistance device are provided. The constant-resistance and large deformation anchor cable comprises cables (7), an anchoring device (13), a loading plate (12) and clipping sheets (4). The upper end of cables (7) is fixed on the anchoring device (13) and the loading plate (12) by clipping sheets (4). The constant-resistance and large deformation anchor cable also comprises a constant-resistance device, and the constant-resistance device comprises a sleeve (8) and a constant-resistance body (5). The sleeve (8) is a straight tube. The constant-resistance body is conical, and the diameter of the lower end of the constant-resistance body is bigger than the diameter of the upper end of the constant-resistance body. The inner diameter of the sleeve (8) is smaller than the diameter of the lower end of the constant-resistance body. A cuneiform part is arranged on inner wall of the lower end of the sleeve (8), and the constant-resistance body (5) is arranged on the cuneiform part. The strength of constant-resistance body (5) is higher than the strength of the sleeve (8), thus the sleeve (8) generates plastic deforming and the shape of the constant-resistance body (5) is not changed, when the constant-resistance body (5) moves in the sleeve (8). The lower end of the cables (7) is fixed on the constant-resistance body (5). The constant-resistance and large deformation anchor cable and the constant-resistance device have the properties of constant-resistance and preventing fracture, and can detect and early warn the all process of the activity of the landslides and the causative fault.

公开(公告)号：US09760372B2

公开(公告)日：2017-09-12

申请号：US13224090

申请日：2011-09-01

申请人： Ren Wu ,  Bin Zhang ,  Meichun Hsu ,  Qiming Chen

发明人： Ren Wu ,  Bin Zhang ,  Meichun Hsu ,  Qiming Chen

IPC分类号： G06F9/30 ,  G06F9/50

CPC分类号： G06F9/30036 ,  G06F9/3001 ,  G06F9/5066

摘要： A method for combining data values through associative operations. The method includes, with a processor, arranging any number of data values into a plurality of columns according to natural parallelism of the associative operations and reading each column to a register of an individual processor. The processors are directed to combine the data values in the columns in parallel using a first associative operation. The results of the first associative operation for each column are stored in a register of each processor.

公开(公告)号：US09305377B2

公开(公告)日：2016-04-05

申请号：US13977030

申请日：2011-12-22

申请人： Patrick Olivier ,  Amy Perkins ,  Bin Zhang ,  Chi-Hua Tung

发明人： Patrick Olivier ,  Amy Perkins ,  Bin Zhang ,  Chi-Hua Tung

IPC分类号： G06K9/00 ,  G06T11/00

CPC分类号： G06T11/003 ,  G06T11/005 ,  G06T2211/412

摘要： A PET scanner (20, 22, 24, 26) generates a plurality of time stamped lines of response (LORs). A motion detector (30) detects a motion state, such as motion phase or motion amplitude, of the subject during acquisition of each of the LORs. A sorting module (32) sorts the LORs by motion state and a reconstruction processor (36) reconstructs the LORs into high spatial, low temporal resolution images in the corresponding motion states. A motion estimator module (40) determines a motion transform which transforms the LORs into a common motion state. A reconstruction module (50) reconstructs the motion corrected LORs into a static image or dynamic images, a series of high temporal resolution, high spatial resolution images.

摘要翻译： PET扫描器（20,22,24,26）产生多个时间戳响应线（LOR）。 运动检测器（30）在获取每个LOR期间检测对象的运动状态，例如运动相位或运动幅度。 分类模块（32）通过运动状态对LOR进行排序，并且重建处理器（36）将LOR重建成相应运动状态的高空间，低时间分辨率图像。 运动估计器模块（40）确定将LOR转换成公共运动状态的运动变换。 重建模块（50）将运动校正LOR重建成静态图像或动态图像，一系列高时间分辨率，高空间分辨率图像。

公开(公告)号：US09244082B2

公开(公告)日：2016-01-26

申请号：US13452018

申请日：2012-04-20

申请人： Lin Mei ,  Wen-Cheng Xiong ,  Bin Zhang ,  Chengyong Shen

发明人： Lin Mei ,  Wen-Cheng Xiong ,  Bin Zhang ,  Chengyong Shen

IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K1/00 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/564 ,  G01N33/92

CPC分类号： G01N33/6896 ,  C07K16/28 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/564 ,  G01N33/6893 ,  G01N33/92 ,  G01N2333/705 ,  G01N2500/04 ,  G01N2800/28 ,  G01N2800/38

摘要： The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.

摘要翻译： 本发明包括用于检测神经传递或发育障碍的方法，包括但不限于对乙酰胆碱受体（AChR）和/或肌肉特异性酪氨酸激酶（MuSK）的自身抗体血清阴性的重症肌无力，所述方法包括检测 与LRP4结合的自身抗体或其表位。 还包括用于治疗患有神经传递障碍的个体的方法，所述方法包括在体液中检测结合LRP4的单个自身抗体或其表位，并向患者施用有效量的免疫抑制剂和/ 或另一适当的治疗方式。 还包括与LRP4自身抗体结合的抗体和用于检测神经传递或发育障碍的试剂盒。

公开(公告)号：US09158117B2

公开(公告)日：2015-10-13

申请号：US12735946

申请日：2009-03-05

申请人： Ming Li ,  Yaping Dai ,  Tao Wang ,  Bin Zhang

发明人： Ming Li ,  Yaping Dai ,  Tao Wang ,  Bin Zhang

IPC分类号： G02B17/00 ,  G02B27/09 ,  G01J3/18 ,  G02B19/00 ,  G01J3/24 ,  G01J3/12 ,  H01S3/00

CPC分类号： G02B27/0944 ,  G01J3/1804 ,  G01J3/24 ,  G01J2003/1282 ,  G02B19/0023 ,  G02B19/0052 ,  G02B27/0927 ,  G02B27/0983 ,  H01S3/005

摘要： A spectra shaping apparatus for chirped pulse amplification(CPA) comprises a CTSI spectral decomposition system and a CTSI spectral synthesizing system being symmetrical, and a spectral modulating system composed of a diaphragm (10) and a plane spectra modulating reflector (5), wherein the CTSI spectral decomposition system totally expands a laser chirped pulse to a spectra plane, the spectral modulating system performs a spectra modulation on the image plane, and the CTSI spectral synthesizing system reverts the modulated spectra into the chirped pulse without distortion, thereby realizing spectra shaping. The apparatus has the feature of manufacturing easy, compacting structure, requiring less space, and cheap in cost etc., which can be different types of configuration for different circumstance application, and which can be utilized in a general laser spectrum shaping and spectrum modulation, especially for a high energy and ultra-high peak-power laser system with a large caliber and a broadband of pulse.

摘要翻译： 用于啁啾脉冲放大（CPA）的光谱整形装置包括对称的CTSI光谱分解系统和CTSI光谱合成系统，以及由光阑（10）和平面光谱调制反射器（5）组成的光谱调制系统，其中 CTSI光谱分解系统将激光啁啾脉冲完全扩展到光谱平面，光谱调制系统在图像平面上进行光谱调制，CTSI光谱合成系统将调制光谱恢复为无畸变的啁啾脉冲，从而实现光谱整形。 该装置具有制造容易，压实结构的特点，需要较少的空间和便宜的成本等，可以为不同情况应用的不同类型的配置，并且其可以用于一般的激光频谱整形和频谱调制， 特别适用于具有大口径和宽带脉冲的高能量和超高峰值功率激光系统。

公开(公告)号：US09154029B2

公开(公告)日：2015-10-06

申请号：US14005543

申请日：2011-10-24

申请人： Linguo Wang ,  Bin Zhang

发明人： Linguo Wang ,  Bin Zhang

IPC分类号： G05F1/00 ,  H02M3/10 ,  H02M3/155 ,  H03F1/02 ,  H02J1/10 ,  H02M1/00 ,  H02M3/156

CPC分类号： H02M3/10 ,  H02M3/155 ,  H02M7/483 ,  H02M2001/0022 ,  H02M2001/0045 ,  H02M2003/1566 ,  H03F1/0227

摘要： A modulation method and modulator for an envelope tracking power supply. An output of a multi-level switching regulator (202) in the envelope tracking power supply modulator is in parallel connection with an output of a linear regulator (201) via an inductor (203) and supplies power to a load. The modulation method for the envelope tracking power supply includes: generating a first control signal (209) according to the current (211) obtained from inputting a first reference level signal (206); comparing the amplitude of a second reference level signal (2061) obtained according to the first reference level signal (206) with preset amplitudes of at least three levels, and outputting a second control signal (210) according to the comparison result and the first control signal (209); the multi-level switching regulator (202) outputting a level signal of corresponding amplitude according to the second control signal (210), and loading the amplitude of the level on the inductor (203) to output an inductive current (208′); and linearly regulating the first reference level signal (206) via a linear regulator (201) to obtain a voltage output (207) to the load. The present disclosure resolves the problem of fixed rate of change of current output by the switching regulator of the envelope tracking power supply regulator and cannot adjust to different load current change rates, thus the inductive current outputted by the multi-level switching regulator can better track the load current change.

摘要翻译： 一种用于包络跟踪电源的调制方法和调制器。 包络跟踪电源调制器中的多电平开关调节器（202）的输出通过电感器（203）与线性调节器（201）的输出并联连接，并向负载供电。 用于包络跟踪电源的调制方法包括：根据从输入第一参考电平信号（206）获得的当前（211）产生第一控制信号（209）; 将根据第一参考电平信号（206）获得的第二参考电平信号（2061）的幅度与至少三个电平的预设幅度进行比较，并且根据比较结果和第一控制输出第二控制信号（210） 信号（209）; 所述多电平开关稳压器（202）根据所述第二控制信号（210）输出对应幅度的电平信号，并且将所述电平的电平加载到所述电感器（203）上以输出感应电流（208'）; 并且经由线性调节器（201）线性调节第一基准电平信号（206）以获得负载的电压输出（207）。 本公开解决了由包络跟踪电源调节器的开关调节器产生的固定电流变化率的问题，并且不能适应不同的负载电流变化率，因此多电平开关调节器输出的感应电流可以更好地跟踪 负载电流变化。

公开(公告)号：US20150148548A1

公开(公告)日：2015-05-28

申请号：US14365638

申请日：2012-07-27

申请人： Bin Zhang ,  Xiaowei Hu ,  Pucha Yan ,  Xianyi Zhang ,  Hongjun Gao ,  Yuanqiang Li ,  Daqing Che

发明人： Bin Zhang ,  Xiaowei Hu ,  Pucha Yan ,  Xianyi Zhang ,  Hongjun Gao ,  Yuanqiang Li ,  Daqing Che

IPC分类号： C07D209/08

CPC分类号： C07D209/08 ,  C07F7/00 ,  C07F7/02 ,  C07F7/18 ,  C07F9/65397 ,  Y02P20/55

摘要： Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R7 is a protecting group of carboxyl, and R2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.

摘要翻译： 公开了一种西洛多辛中间体及其制备方法。 西洛德辛中间体具有式（A）所示的结构。 X是氢或溴，R 1是氢。 甲酰基可以是具有式I所示结构的基团.R 7是羧基的保护基，R 2是3-羟丙基或具有式II所示结构的基团。 W是羟基的保护基。 根据本发明的式（A）化合物还可用于制备具有式（D）所示结构的化合物。 通过本发明提供的中间体及其制备方法，可以获得高纯度的光学纯的芝麻酮，光学纯度高于99％。

公开(公告)号：US08918397B2

公开(公告)日：2014-12-23

申请号：US13561468

申请日：2012-07-30

申请人： Heng Cao ,  Jin Dong ,  Jacqueline Giang Huong Morris ,  Ming Xie ,  Wen Jun Yin ,  Bin Zhang

发明人： Heng Cao ,  Jin Dong ,  Jacqueline Giang Huong Morris ,  Ming Xie ,  Wen Jun Yin ,  Bin Zhang

IPC分类号： G06F17/30 ,  G06Q30/02

CPC分类号： G06Q30/02

摘要： A computer implemented method for clustering customers includes receiving a source set of customer records, wherein each customer record represents one customer, and each customer record includes at least one data attribute, and each data attribute has an attribute value; pre-processing the source set of customer records to generate a pre-processed set of customer records; executing a clustering algorithm on the pre-processed set of customer records to group the pre-processed set of customer records into clusters of a pre-defined number. The pre-processing comprises: determining the type of a customer in the source set of customer records; using a type attribute value to indicate the type of the customer in its customer record; normalizing data attribute values and type attribute values; weighting to the data attribute values and the type attribute values respectively to obtain weighted attribute values of the data attribute and weighted attribute values of the type attribute.

摘要翻译： 用于聚类客户的计算机实现方法包括接收客户记录的源集合，其中每个客户记录表示一个客户，并且每个客户记录包括至少一个数据属性，并且每个数据属性具有属性值; 预处理客户记录的源集合以生成预处理的一组客户记录; 在预处理的客户记录集上执行聚类算法，以将预处理的客户记录集合分组成预定义数量的集群。 预处理包括：确定客户记录源组中客户的类型; 使用类型属性值来指示客户记录中客户的类型; 归一化数据属性值和类型属性值; 分别对数据属性值和类型属性值进行加权，以获得类型属性的数据属性和加权属性值的加权属性值。

公开(公告)号：US08871114B2

公开(公告)日：2014-10-28

申请号：US13586677

申请日：2012-08-15

申请人： Hiroaki Miyagawa ,  Bin Zhang ,  James Chienchung Shih

发明人： Hiroaki Miyagawa ,  Bin Zhang ,  James Chienchung Shih

IPC分类号： C09K11/77 ,  H05B33/14

CPC分类号： C09K11/7774 ,  C09K11/7721 ,  F21V9/30 ,  G21K5/00 ,  H01L33/502 ,  H05B33/14

摘要： Disclosed herein are emissive ceramic elements having low amounts of certain trace elements. Applicants have surprisingly found that a lower internal quantum efficiency (IQE) may be attributed to specific trace elements that, even at very low amounts (e.g., 50 ppm or less), can cause significant deleterious effects on IQE. In some embodiments, the emissive ceramic element includes a garnet host material and an amount of Ce dopant. The emissive ceramic element may, in some embodiments, have an amount of Na in the composition less than about 67 ppm, an amount of Mg in the composition less than about 23 ppm, or an amount of Fe in the composition less than about 21 ppm.

摘要翻译： 本文公开了具有少量某些微量元素的发光陶瓷元件。 申请人惊奇地发现，较低的内部量子效率（IQE）可归因于特定的微量元素，甚至在非常低的量（例如，50ppm或更少）下也可能对IQE产生显着的有害影响。 在一些实施例中，发射陶瓷元件包括石榴石主体材料和一定量的Ce掺杂剂。 在一些实施方案中，发光陶瓷元件可以具有小于约67ppm的组成中的Na的量，组合物中的Mg的量小于约23ppm，或组合物中的Fe的量小于约21ppm 。

公开(公告)号：US08828531B2

公开(公告)日：2014-09-09

申请号：US13306797

申请日：2011-11-29

申请人： Guang Pan ,  Hiroaki Miyagawa ,  Hironaka Fujii ,  Bin Zhang ,  Rajesh Mukherjee ,  Toshitaka Nakamura ,  Amane Mochizuki

发明人： Guang Pan ,  Hiroaki Miyagawa ,  Hironaka Fujii ,  Bin Zhang ,  Rajesh Mukherjee ,  Toshitaka Nakamura ,  Amane Mochizuki

IPC分类号： B32B3/26 ,  B32B18/00 ,  C09K11/00 ,  C09K11/80 ,  C09K11/77 ,  C04B35/638 ,  C04B35/44 ,  C04B35/626 ,  H01L33/50

CPC分类号： C09K11/7774 ,  B32B18/00 ,  C04B35/44 ,  C04B35/6261 ,  C04B35/62665 ,  C04B35/6268 ,  C04B35/638 ,  C04B38/00 ,  C04B2111/807 ,  C04B2235/3225 ,  C04B2235/3229 ,  C04B2235/3418 ,  C04B2235/441 ,  C04B2235/5409 ,  C04B2235/6025 ,  C04B2235/604 ,  C04B2235/6562 ,  C04B2235/6565 ,  C04B2235/6581 ,  C04B2235/661 ,  C04B2235/663 ,  C04B2235/75 ,  C04B2235/764 ,  C04B2235/9646 ,  C04B2235/9653 ,  C04B2235/9661 ,  C04B2237/343 ,  C04B2237/582 ,  C04B2237/586 ,  C04B2237/704 ,  C09K2211/182 ,  H01L33/502 ,  H01L33/505 ,  H01L51/52 ,  Y10T428/249953 ,  Y10T428/249961 ,  Y10T428/24997 ,  Y10T428/24999 ,  C04B38/0655

摘要： Disclosed herein are emissive ceramic materials having a dopant concentration gradient along a thickness of a yttrium aluminum garnet (YAG) region. The dopant concentration gradient may include a maximum dopant concentration, a half-maximum dopant concentration, and a slope at or near the half-maximum dopant concentration. The emissive ceramics may, in some embodiments, exhibit high internal quantum efficiencies (IQE). The emissive ceramics may, in some embodiments, include porous regions. Also disclosed herein are methods of make the emissive ceramic by sintering an assembly having doped and non-doped layers.

摘要翻译： 本文公开了具有沿钇铝石榴石（YAG）区域的厚度的掺杂剂浓度梯度的发射陶瓷材料。 掺杂剂浓度梯度可以包括最大掺杂剂浓度，半最大掺杂剂浓度以及在半最大掺杂剂浓度处或附近的斜率。 在一些实施例中，发射陶瓷可表现出高的内部量子效率（IQE）。 在一些实施例中，发光陶瓷可以包括多孔区域。 本文还公开了通过烧结具有掺杂层和非掺杂层的组件来制造发光陶瓷的方法。