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    Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
    53.
    发明授权
    Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals 有权
    使用遗传相关个体的遗传数据确定目标个体基因组染色体拷贝数的方法

    公开(公告)号：US08532930B2

    公开(公告)日：2013-09-10

    申请号：US11603406

    申请日：2006-11-22

    Applicant: Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Paul Demko ,  David Scott Johnson

    Inventor： Matthew Rabinowitz ,  Milena Banjevic ,  Zachary Paul Demko ,  David Scott Johnson

    IPC: G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58

    CPC classification number: G06F19/20 ,  G06F19/18

    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell is reconstructed using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In accordance with another embodiment of the invention, incomplete genetic data from a fetus is acquired from fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals. In one embodiment, the genetic data can be reconstructed for the purposes of making phenotypic predictions. In another embodiment, the genetic data can be used to detect for aneuploides and uniparental disomy.

    Abstract translation: 用于确定有限数量的遗传数据可用的一个或一小组细胞或来自片段DNA的遗传数据的系统和方法。 使用已知方法获取和扩增目标个体的遗传数据，并且使用目标基因组与基因相关受试者的基因组之间的预期相似性重建差测量的碱基对，缺失的等位基因和缺失区域。 根据本发明的一个实施方案，使用来自一个或两个亲本的二倍体细胞的较大样本的更完整的遗传数据重建来自胚胎细胞的不完整遗传数据，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据 ，和/或从其他相关个体获取的遗传数据。 根据本发明的另一个实施方案，从胎儿细胞或从母体血液中分离的无细胞胎儿DNA获得来自胎儿的不完整遗传数据，并且使用来自较大样本的更完整的遗传数据重建不完全遗传数据 来自一个或两个父母的二倍体细胞，具有或不具有来自一个或两个亲本的单倍体细胞的遗传数据和/或从其他相关个体获取的遗传数据。 在一个实施方案中，为了进行表型预测的目的，可以重建遗传数据。 在另一个实施方案中，遗传数据可用于检测非整倍体和单倍体二体解剖。

    METHODS FOR ALLELE CALLING AND PLOIDY CALLING
    54.
    发明申请
    METHODS FOR ALLELE CALLING AND PLOIDY CALLING 有权
    用于呼叫和呼叫呼叫的方法

    公开(公告)号：US20130225422A1

    公开(公告)日：2013-08-29

    申请号：US13846111

    申请日：2013-03-18

    Applicant: Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Joshua Sweetkind-Singer

    Inventor： Matthew Rabinowitz ,  George Gemelos ,  Milena Banjevic ,  Allison Ryan ,  Joshua Sweetkind-Singer

    IPC: G06F19/18

    CPC classification number: G06F19/18 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/24

    Abstract: Disclosed herein is a system and method for making allele calls, and for determining the ploidy state, in one or a small set of cells, or where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed and the haplotypes are determined using expected similarities between the target genome and the knowledge of the genomes of genetically related individuals. In one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the genetic data from both parents, and possibly one or more sperm and/or sibling embryos. In another embodiment, the chromosome copy number can be determined using the same input data. In another embodiment, these determinations are made for embryo selection during IVF, for non-invasive prenatal diagnosis, or for making phenotypic predictions.

    Abstract translation: 本文公开了一种用于在一个或一小组细胞中或其中有限数量的遗传数据可用的等位基因调用和用于确定倍性状态的系统和方法。 重建不良或不正确的碱基对，缺失的等位基因和缺失区域，并使用目标基因组与遗传相关个体基因组知识之间的预期相似性来确定单倍型。 在一个实施方案中，使用来自双亲和可能的一个或多个精子和/或同胞胚胎的遗传数据在多个基因座重建来自胚胎细胞的不完全遗传数据。 在另一个实施方案中，可以使用相同的输入数据来确定染色体拷贝数。 在另一个实施方案中，进行这些测定用于IVF期间的胚胎选择，用于非侵入性产前诊断或用于进行表型预测。

    Positioning and time transfer using television synchronization signals
    55.
    发明授权
    Positioning and time transfer using television synchronization signals 有权
    使用电视同步信号进行定位和时间传输

    公开(公告)号：US08233091B1

    公开(公告)日：2012-07-31

    申请号：US12117676

    申请日：2008-05-08

    Applicant: Matthew Rabinowitz ,  James J. Spilker, Jr. ,  Scott Furman ,  Dimitri Rubin ,  Harvind Samra ,  David Burgess ,  Guttorm Opshaug ,  Jim Omura

    Inventor： Matthew Rabinowitz ,  James J. Spilker, Jr. ,  Scott Furman ,  Dimitri Rubin ,  Harvind Samra ,  David Burgess ,  Guttorm Opshaug ,  Jim Omura

    IPC: H04N5/44

    CPC classification number: H04N5/06 ,  G01S5/14 ,  H04H60/51 ,  H04N7/0352

    Abstract: Methods having corresponding apparatus and computer-readable media comprise: receiving television signals and a message at an apparatus, wherein the television signals include an NTSC television signal and an ATSC television signal, wherein the message represents first and second arrival times representing absolute times of arrival at the apparatus of a first wavefront of the NTSC and ATSC television signals, respectively; measuring third and fourth arrival times, based on a local clock, after receiving the message, wherein the third and fourth arrival times represent times of arrival at the apparatus of a second wavefront of the NTSC and ATSC television signals, respectively; and providing a clock correction signal for the local clock based on the first arrival time, the second arrival time, the third arrival time, and the fourth arrival time.

    Abstract translation: 具有对应装置和计算机可读介质的方法包括：在装置处接收电视信号和消息，其中电视信号包括NTSC电视信号和ATSC电视信号，其中该消息表示代表绝对到达时间的第一和第二到达时间 分别在NTSC和ATSC电视信号的第一波前的设备上; 在接收到消息之后，基于本地时钟测量第三和第四到达时间，其中第三和第四到达时间分别表示NTSC和ATSC电视信号的第二波前的设备的到达时间; 以及基于第一到达时间，第二到达时间，第三到达时间和第四到达时间为本地时钟提供时钟校正信号。

    Positioning in a single-frequency network
    57.
    发明授权
    Positioning in a single-frequency network 失效
    定位在单频网络中

    公开(公告)号：US07737893B1

    公开(公告)日：2010-06-15

    申请号：US11770162

    申请日：2007-06-28

    Applicant: Scott Furman ,  Matthew Rabinowitz

    Inventor： Scott Furman ,  Matthew Rabinowitz

    IPC: G01S3/02

    CPC classification number: G01S5/0215 ,  G01S5/0226 ,  G01S5/145 ,  G01S19/46

    Abstract: Apparatus having corresponding methods and computer-readable media comprise a receiver adapted to receive a plurality of single-frequency network (SFN) signals at a predetermined frequency; a correlator adapted to correlate the SFN signals with a predetermined reference signal, wherein correlating produces a plurality of correlation peaks; a grouper circuit adapted to group the correlation peaks into arrival groups such that the correlation peaks in different arrival groups are known to be from different transmitters; and a selection circuit adapted to select the earliest correlation peak in each arrival group as a leading correlation peak.

    Abstract translation: 具有相应方法和计算机可读介质的装置包括适于以预定频率接收多个单频网络（SFN）信号的接收机; 相关器，其适于使所述SFN信号与预定参考信号相关，其中相关产生多个相关峰值; 分组电路，适于将相关峰值分组到到达组中，使得不同到达组中的相关峰值已知来自不同发射机; 以及选择电路，其适于选择每个到达组中的最早相关峰作为前导相关峰。

    Method and system for generating reference signals with improved correlation characteristics for accurate time of arrival or position determination
    59.
    发明授权
    Method and system for generating reference signals with improved correlation characteristics for accurate time of arrival or position determination 有权
    用于产生参考信号的方法和系统，具有改进的相关特性，用于准确的到达时间或位置确定

    公开(公告)号：US07307665B2

    公开(公告)日：2007-12-11

    申请号：US10740881

    申请日：2003-12-22

    Applicant: Guttorm Ringstad Opshaug ,  Matthew Rabinowitz ,  Jimmy K. Omura

    Inventor： Guttorm Ringstad Opshaug ,  Matthew Rabinowitz ,  Jimmy K. Omura

    IPC: H04N7/00 ,  H04N7/04 ,  H04N11/00 ,  G01S3/02

    CPC classification number: G01S5/14 ,  G01S5/0221 ,  G01S5/145 ,  G01S19/46

    Abstract: The present invention provides a method and system for generating reference signals that, when correlated with synchronization code signals or other components of broadcast TV signals, yield minimal sidelobes, produce large main peaks, and have minimal couplings to high frequency noise and low frequency disturbance signals. The present invention also provides a method and system for accurate position determination utilizing broadcast TV signals by employing reference signals with improved correlation characteristics of minimal sidelobes, minimal coupling to high frequency noise, minimal coupling to low frequency disturbance signals and a maximal main correlation peak.

    Abstract translation: 本发明提供了一种用于产生参考信号的方法和系统，当与同步码信号或广播TV信号的其他分量相关时，产生最小旁瓣，产生大的主峰，并且对高频噪声和低频干扰信号具有最小耦合 。 本发明还提供一种利用广播电视信号进行准确位置确定的方法和系统，该参考信号具有改进的最小旁瓣相关特性，与高频噪声的最小耦合，与低频干扰信号的最小耦合以及最大主相关峰值的参考信号。

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