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公开(公告)号：US20120316116A1
公开(公告)日：2012-12-13
申请号：US13493926
申请日：2012-06-11
CPC分类号： A61K38/36 , A61K38/37 , A61K2300/00
摘要： The present invention provides methods of treating coagulation disease, including hemophilia and von Willebrand disease by administering recombinant von Willebrand Factor alone or in combination with Factor VIII.
摘要翻译： 本发明提供通过单独施用重组血管性血友病因子或与因子VIII组合来治疗凝血疾病的方法，包括血友病和血管性血友病。
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52.发明授权Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies 有权抗Von Willebrand因子切割蛋白酶（ADAMTS13）抗体的诊断测定公开(公告)号：US07943326B2
公开(公告)日：2011-05-17
申请号：US12829872
申请日：2010-07-02
IPC分类号： G01N33/53
摘要： This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease (“anti-vWF-cp”) antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
摘要翻译： 本发明涉及一种用于测定样品中抗血管性血友病因子切割蛋白酶（“vWF-cp”）抗体的测定系统的试剂盒。 该试剂盒包含固定在固相上的vWF-cp和/或vWF-片段。 该试剂盒可用于测定来自患者的抗vWF-cp抗体的方法，用于诊断与抗vWF-cp抗体发生相关的病症，以及各种形式的血栓性微血管病变的分化。
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53.发明授权Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权表现出von Willebrand因子（vWF）蛋白酶活性的组合物，其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号：US07910094B2
公开(公告)日：2011-03-22
申请号：US12370129
申请日：2009-02-12
申请人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人： Bernhard Laemmle , Helena Elisabeth Schaller-Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号： A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要： The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.
摘要翻译： 本发明涉及分子量为180kD，170kD，160kD，120kD或110kD的VWF切割实体以及AAGGILHLELLV的N-末端氨基酸序列，vWF切割复合物及其生产方法。
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公开(公告)号：US20100260768A1
公开(公告)日：2010-10-14
申请号：US12767635
申请日：2010-04-26
申请人： Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
发明人： Randolf Kerschbaumer , Friedrich Scheiflinger , Manfred Rieger , Michael Thiele , Geert C. Mudde , Juergen Muellberg , Rene Hoet
IPC分类号： A61K39/395 , C07K16/24 , A61P35/00 , A61P37/02 , A61P29/00 , C07H21/04 , C12N5/07 , C12N15/63 , C12N5/10 , C12P21/08 , G01N33/53
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
摘要翻译： 本发明涉及特异性结合巨噬细胞迁移抑制因子（MIF）的C端或中心区域的单克隆抗体及其抗原结合部分。 这些抗MIF抗体及其抗原结合部分进一步抑制人MIF生物学功能。 本发明还涉及衍生自抗MIF抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及鉴定抗MIF抗体的方法，包含这些抗体的药物组合物和使用这些抗体和组合物用于治疗MIF相关病症的方法。
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公开(公告)号：US20090176708A1
公开(公告)日：2009-07-09
申请号：US12339619
申请日：2008-12-19
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/644 , A61K38/00 , C12N9/96 , C12Y304/21022
摘要： The present invention discloses a chemically modified FIX, wherein the activation peptide region contains a covalently coupled water-soluble hydrophilic polymer.
摘要翻译： 本发明公开了一种化学修饰的FIX，其中活化肽区含有共价偶联的水溶性亲水性聚合物。
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公开(公告)号：US20080176287A1
公开(公告)日：2008-07-24
申请号：US12058473
申请日：2008-03-28
IPC分类号： C12P21/04
CPC分类号： C12N9/644 , A61K38/36 , C12Y304/21022
摘要： The present invention relates to a purified recombinant blood coagulation factor IX (rFIX) preparation, wherein at least 25% of the rFIX in the preparation is fully phosphorylated and sulfated, a cell culture expressing a rFIX resulting in said preparation, a pharmaceutical composition for treating a bleeding disorder comprising said preparation, and a method for treating a bleeding disorder comprising the step of administering said preparation to a patient in need thereof.
摘要翻译： 本发明涉及纯化的重组凝血因子IX（rFIX）制剂，其中至少25％的制剂中的rFIX被完全磷酸化和硫酸化，表达产生所述制备的rFIX的细胞培养物，用于治疗的药物组合物 包括所述制剂的出血病症和治疗出血性疾病的方法，包括将所述制剂给予需要的患者的步骤。
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57.发明授权公开(公告)号：US07297336B2
公开(公告)日：2007-11-20
申请号：US10661366
申请日：2003-09-12
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/40
摘要： Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating patients afflicted with blood coagulation with such ligands, and a nucleic acid that encodes, or a cell that expresses such ligands, are provided.
摘要翻译： 配体，例如可以结合因子IX /因子IXa并增加因子IXa（FIXa）的促凝血活性的抗体，含有这种配体的药物组合物，用这种配体治疗患有凝血的患者的方法，以及编码或 提供表达这种配体的细胞。
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公开(公告)号：US20070244036A1
公开(公告)日：2007-10-18
申请号：US11683362
申请日：2007-03-07
CPC分类号： C12N9/644 , A61K38/36 , C12Y304/21022
摘要： The present invention relates to a purified recombinant blood coagulation factor IX (rFIX) preparation, wherein at least 25% of the rFIX in the preparation is fully phosphorylated and sulfated, a cell culture expressing a rFIX resulting in said preparation, a pharmaceutical composition for treating a bleeding disorder comprising said preparation, and a method for treating a bleeding disorder comprising the step of administering said preparation to a patient in need thereof.
摘要翻译： 本发明涉及纯化的重组凝血因子IX（rFIX）制剂，其中至少25％的制剂中的rFIX被完全磷酸化和硫酸化，表达产生所述制备的rFIX的细胞培养物，用于治疗的药物组合物 包括所述制剂的出血病症和治疗出血性疾病的方法，包括将所述制剂给予需要的患者的步骤。
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59.发明授权公开(公告)号：US07033590B1
公开(公告)日：2006-04-25
申请号：US09661992
申请日：2000-09-14
申请人： Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
发明人： Friedrich Scheiflinger , Randolf Kerschbaumer , Falko-Guenter Falkner , Friedrich Dorner , Hans-Peter Schwarz
IPC分类号： A61K39/395 , A61K38/04 , C12N5/20 , C07K16/00 , C07K16/34
CPC分类号： C07K16/40 , A61K2039/505
摘要： An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa.
摘要翻译： 针对因子IX /活化因子IX（FIXa）的抗体或抗体衍生物，其增加FIXa的促凝血活性。
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60.发明授权Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV 有权表现出von Willebrand因子（vWF）蛋白酶活性的组合物，其包含具有氨基酸序列AAGGILHLELLV的多肽链公开(公告)号：US06926894B2
公开(公告)日：2005-08-09
申请号：US09833328
申请日：2001-04-12
申请人： Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
发明人： Bernhard Laemmle , Helena Elisabeth Gerritsen , Miha Furlan , Peter Turecek , Hans-Peter Schwarz , Friedrich Scheiflinger , Gerhard Antoine , Randolf Kerschbaumer , Luigina Tagliavacca , Klaus Zimmermann
CPC分类号： A61K38/4886 , A61K38/00 , C07K14/755 , C07K16/36 , C12N9/6416 , C12N9/6489 , C12Y304/24087
摘要： The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.
摘要翻译： 本发明涉及分子量为180kD，170kD，160kD，120kD或110kD的VWF切割实体以及AAGGILHLELLV（SEQ ID NO：1）的N-末端氨基酸序列，vWF切割复合物和用于 他们的生产。
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