公开(公告)号：US06681788B2

公开(公告)日：2004-01-27

申请号：US10056219

申请日：2002-01-24

申请人： J. Wallace Parce ,  Andrea W. Chow

发明人： J. Wallace Parce ,  Andrea W. Chow

IPC分类号： F15C118

CPC分类号： F15C1/04 ,  B01L3/02 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/06 ,  Y10T137/0396 ,  Y10T137/2076 ,  Y10T137/2142 ,  Y10T137/218 ,  Y10T137/2191 ,  Y10T137/2273

摘要： Methods devices and systems that employ non-mechanical valve modules for controllably directing fluid and other material movement through integrated microscale channel networks. These non-mechanical valve modules apply forces that counter the driving forces existing through a given channel segment, via fluidly connected channel segments, so as to selectively arrest flow of material within the given channel segment.

摘要翻译： 方法使用非机械阀模块的装置和系统，用于可控地引导流体和其他材料运动通过集成的微型通道网络。 这些非机械阀模块通过流体连接的通道段施加抵抗通过给定通道段存在的驱动力的力，以便选择性地阻止给定通道段内的材料流。

公开(公告)号：US06669831B2

公开(公告)日：2003-12-30

申请号：US09854141

申请日：2001-05-10

申请人： Andrea W. Chow ,  Carlton Brooks

发明人： Andrea W. Chow ,  Carlton Brooks

IPC分类号： B01D5702

CPC分类号： B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00891 ,  B01J2219/00961 ,  B01J2219/00966 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01L3/502746 ,  B01L2200/06 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0415 ,  G01N27/44704 ,  G01N27/44747 ,  G01N27/44791 ,  Y10T137/2065 ,  Y10T436/25 ,  Y10T436/25625

摘要： Methods and devices for inducing high bulk hydrodynamic resistance and/or for inducing low electrical resistance in microscale systems including bulk viscosity enhancers, surfactants, and electrolytes. High bulk hydrodynamic resistance is optionally utilized to regulate the effects of spontaneous injection and/or dispersion. Induced high hydrodynamic resistance in conjunction with induced low electrical resistance are optionally utilized to provide and regulate electrical fields within microfluidic devices. Integrated systems incorporating the methods of the invention are also provided.

公开(公告)号：US09683994B2

公开(公告)日：2017-06-20

申请号：US13544006

申请日：2012-07-09

申请人： Andrea W. Chow ,  John C. Owicki ,  J. Wallace Parce

发明人： Andrea W. Chow ,  John C. Owicki ,  J. Wallace Parce

IPC分类号： G01N27/447 ,  G01N33/557 ,  B01L3/00 ,  G01N33/53 ,  B01L7/00

CPC分类号： G01N33/557 ,  B01L3/50273 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1822 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0487 ,  G01N27/44791 ,  G01N33/5306

摘要： The present invention provides novel methods for performing pulsed field mobility shift assays in microfluidic devices. In particular, the methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and thus analyze the reaction.

公开(公告)号：US07150814B1

公开(公告)日：2006-12-19

申请号：US10214961

申请日：2002-08-08

申请人： J. Wallace Parce ,  Andrea W. Chow

发明人： J. Wallace Parce ,  Andrea W. Chow

IPC分类号： G01N27/453 ,  G01N30/02

CPC分类号： B08B17/00 ,  B01L3/50273 ,  B01L2300/0816 ,  B01L2300/1833 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N27/44704 ,  G01N27/44752

摘要： Methods and apparatus for reducing adsorption in microscale devices are provided. In the methods and apparatus, an electrical current such as an alternating current is applied to materials under pressure-induced flow. Integrated systems for simultaneous control of current and pressure in a channel are also provided.

公开(公告)号：US07001716B2

公开(公告)日：2006-02-21

申请号：US10442006

申请日：2003-05-20

申请人： Samuel D. H. Chan ,  Ring-Ling Chien ,  Andrea W. Chow ,  Benjamin N. Wang

发明人： Samuel D. H. Chan ,  Ring-Ling Chien ,  Andrea W. Chow ,  Benjamin N. Wang

IPC分类号： C12Q1/00

CPC分类号： G01N21/64 ,  B01J19/0093 ,  B01L3/5027 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0415 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N21/6428 ,  G01N21/75 ,  G01N30/02 ,  G01N2021/6482 ,  B01D15/3857

摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.

摘要翻译： 用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。 通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。

公开(公告)号：US5573738A

公开(公告)日：1996-11-12

申请号：US272193

申请日：1994-07-08

申请人： Jonathan K. Ma ,  Andrea W. Chow ,  Scott A. Ranger ,  David W. Peters ,  Ronald F. May

发明人： Jonathan K. Ma ,  Andrea W. Chow ,  Scott A. Ranger ,  David W. Peters ,  Ronald F. May

IPC分类号： B09C1/02 ,  C22B60/02 ,  C01G43/00

CPC分类号： B09C1/02 ,  C22B60/0234 ,  C22B60/0252

摘要： Soil, contaminated with radioactive material such as uranium, is treated to remove the radioactive contaminant. The soil is first pre-processed to remove and clean oversized particles for release back to the environment as recovered soil. Pre-processing also includes removal of metallic uranium from the soil by gravimetric separation for off-site disposal. An aqueous slurry is formed from the pre-processed feed which is fed to a mechanical separation device. Particles greater than 10 mesh are crushed to provide a uniform feed slurry. The slurry is processed in an aqueous leaching solution of sulfuric acid, hydrogen peroxide and iron to remove uranium. Particulate matter is removed from the acidic slurry; the remaining fine particulate matter is then submitted to a second-stage leaching to remove residual uranium. Uranium is recovered from the combined leaching solutions by either a two-stage precipitation process or by passage over an ion-exchange material. The process utilizes a closed loop system for process water which is reclaimed, clarified, and recirculated for reuse.

摘要翻译： 被污染的放射性物质如铀的土壤被处理以去除放射性污染物。 首先对土壤进行预处理，以去除和清洁过大的颗粒，作为回收土壤释放回环境。 预处理还包括通过重力分离从土壤中去除金属铀，用于非现场处理。 由预处理的进料形成含水浆料，该原料进料到机械分离装置。 大于10目的颗粒被粉碎以提供均匀的进料浆料。 在硫酸，过氧化氢和铁的水性浸出溶液中处理浆料以除去铀。 颗粒物质从酸性浆液中除去; 然后将剩余的细颗粒物质进行第二阶段浸出以除去残留的铀。 通过两步沉淀法或通过离子交换材料，从合并的浸出溶液中回收铀。 该方法利用回收系统，用于回收，澄清和再循环用于再利用的工艺用水。