公开(公告)号：US20140039358A1

公开(公告)日：2014-02-06

申请号：US13956407

申请日：2013-08-01

申请人： Muffin Incorporated

发明人： Yun Zhou ,  Peter S. McKinnis ,  Sarah Robbins ,  Neal E. Fearnot

IPC分类号： A61N7/02

CPC分类号： A61N7/022 ,  A61B17/2202 ,  A61B2017/22001 ,  A61B2017/22021 ,  A61B2017/22054 ,  A61B2017/22062 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61B2018/00023 ,  A61M25/1006 ,  A61M25/1011 ,  A61M37/0092 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1086

摘要： Systems and methods for treating a blood clot positioned within a blood vessel are disclosed. In one embodiment, a balloon member is positioned on a distal end region of a catheter and an ultrasound emitting element is positioned within the balloon member and arranged for actively emitting ultrasound. In some exemplary embodiments, the disclosure provides a multi-wall balloon member and a multi-lumen catheter with at least one and/or all cavities of the balloon member arranged for heat transfer with the ultrasound emitting element. The disclosure also provides catheter arrangements with an ultrasound emitting element arranged to heat tissue adjacent to the balloon member. Additionally, in some embodiments, at least one and/or all walls of the balloon member have apertures arranged to release a therapeutic agent such as a thrombolytic drug.

摘要翻译： 公开了一种用于治疗位于血管内的血块的系统和方法。 在一个实施例中，球囊构件定位在导管的远端区域上，并且超声发射元件位于球囊构件内并被布置用于主动发射超声波。 在一些示例性实施例中，本公开提供了一种多壁球囊构件和多腔导管，其具有布置成与超声发射元件传热的气囊构件的至少一个和/或所有空腔。 本公开还提供具有布置成加热邻近气囊构件的组织的超声发射元件的导管装置。 另外，在一些实施例中，球囊构件的至少一个和/或所有壁具有布置成释放治疗剂如孔溶解药物的孔。

公开(公告)号：US11071521B2

公开(公告)日：2021-07-27

申请号：US14854163

申请日：2015-09-15

申请人： Muffin Incorporated

发明人： William J. Havel ,  Sarah Robbins ,  Peter S. McKinnis ,  Yun Zhou ,  Neal E. Fearnot

IPC分类号： A61B8/00 ,  A61B8/12 ,  A61B1/00

摘要： There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.

公开(公告)号：US20210093452A1

公开(公告)日：2021-04-01

申请号：US17032283

申请日：2020-09-25

申请人： Muffin Incorporated

发明人： William J. Havel ,  Neal E. Fearnot ,  Jeremy T. Newkirk ,  Shaun Davis Gittard ,  John C. Sigmon, JR. ,  Gregory James Hardy ,  Rita Hadley

IPC分类号： A61F2/24

摘要： Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening. Embodiments of tensioning members, protective members, and devices and methods for open-surgical placement (e.g. around a heart for annuloplasty) are also disclosed.

公开(公告)号：US20190247043A1

公开(公告)日：2019-08-15

申请号：US16394192

申请日：2019-04-25

申请人： Muffin Incorporated

发明人： Shaun Davis Gittard ,  John C. Sigmon, JR. ,  Gregory James Hardy ,  Michelle Martinez ,  Vihar C. Surti ,  Jeremy T. Newkirk ,  William J. Havel ,  Neal E. Fearnot

IPC分类号： A61B17/04

CPC分类号： A61B17/0487 ,  A61B2017/00367 ,  A61B2017/0496

摘要： Among other things, there are shown embodiments of locking mechanisms for holding sutures in tension. Such devices may be used with implants that use or require sutures, and are easily locked remotely. In particular embodiments, a lock includes a housing member, a pin member at least partially within the housing member, and a spring biasing the pin member into the housing member. The pin member includes a gripping portion, and has a retracted condition and a locked condition. When retracted, a suture can move through the housing member and around the gripping portion of the pin member. When locked, the gripping portion of the pin member engages the suture and presses it against the interior of the housing member.

公开(公告)号：US20190247035A1

公开(公告)日：2019-08-15

申请号：US16394182

申请日：2019-04-25

申请人： Muffin Incorporated

发明人： Shaun Davis Gittard ,  Gregory James Hardy ,  John C. Sigmon, JR. ,  Jeremy T. Newkirk ,  William J. Havel ,  Neal E. Fearnot

IPC分类号： A61B17/02 ,  A61B90/00

CPC分类号： A61B17/0218 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/00557 ,  A61B2017/00845 ,  A61B2017/00955 ,  A61B2017/0225 ,  A61B2017/0237 ,  A61B2017/3486 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61M25/0041 ,  A61M25/0045 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/0108 ,  A61M25/0662 ,  A61M25/10 ,  A61M2025/0047 ,  A61M2025/1079 ,  A61M2025/1093

摘要： Among other things, there is disclosed structure and methods for maintaining access to a location in the body while reducing or eliminating the potential for pulling an access device (e.g. a catheter) back through an opening. An introducer sheath includes a distal indented portion and a balloon, so that once placed in a desired location through tissue, the balloon can be inflated to anchor the sheath against retraction. In particular embodiments, structure and methods for accessing the pericardial cavity via the right atrial appendage are shown.

公开(公告)号：US20190151092A1

公开(公告)日：2019-05-23

申请号：US16174779

申请日：2018-10-30

申请人： Muffin Incorporated

发明人： Shaun Davis Gittard ,  John C. Sigmon, JR. ,  Gregory James Hardy ,  Jeremy T. Newkirk ,  Neal E. Fearnot ,  William J. Havel ,  Rita Hadley ,  Yun Zhou

IPC分类号： A61F2/24 ,  A61B17/04 ,  A61B5/00

摘要： Among other things, there are disclosed embodiments of belts or bands that can be used in treatments for tricuspid valve regurgitation. In some embodiments, such belts may be heat-set in a particular configuration to effectively decrease tricuspid annulus when deployed around the atrioventricular groove. Embodiments include one or more tensioning sutures for applying cinching or tightening to belts when deployed, and structure for effectively distributing force during such tightening.

公开(公告)号：US20180338763A1

公开(公告)日：2018-11-29

申请号：US15602457

申请日：2017-05-23

申请人： Muffin Incorporated

发明人： Gregory James Hardy ,  Shaun Davis Gittard ,  John C. Sigmon, JR. ,  William J. Havel ,  Jeremy T. Newkirk ,  Neal E. Fearnot ,  Rita Hadley

IPC分类号： A61B17/08 ,  A61B17/10

摘要： There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.

公开(公告)号：US10077423B2

公开(公告)日：2018-09-18

申请号：US14614491

申请日：2015-02-05

申请人： Muffin Incorporated

发明人： Neal E. Fearnot

IPC分类号： C12N5/071 ,  B01L7/00 ,  A01N1/02

CPC分类号： C12N5/0602 ,  A01N1/0231 ,  A01N1/0263 ,  B01L7/50 ,  B01L2300/069

摘要： Described are medical products, methods, and cryogenic bags or other containers suitable for storing and/or transporting and/or processing cellular compositions and other related materials. In certain aspects, the contents of such cryogenic bags may be warmed, mixed, and applied to a patient. Medical products described herein find particular use in treating diseased and/or damaged tissue such as in wound repair and/or bone repair. Related methods of manufacture are also described.

公开(公告)号：US10034655B2

公开(公告)日：2018-07-31

申请号：US14170705

申请日：2014-02-03

申请人： Muffin Incorporated

发明人： Peter S. McKinnis ,  Yun Zhou ,  Neal E. Fearnot

IPC分类号： A61B90/00 ,  A61B8/08 ,  A61B5/06

CPC分类号： A61B8/481 ,  A61B5/065 ,  A61B8/0841 ,  A61B8/488 ,  A61B90/39 ,  A61B2090/3925

摘要： Devices and methods for enhancing observability under ultrasound imaging of medical devices include temporal markers which are dynamic, producing a variable ultrasound image over time. Included are rotating markers which produce a Doppler shift visible through ultrasound imaging in a Doppler mode and which enhance visibility of the marker. Other devices and methods include alternating streams of fluid contrast agents and saline as well as destroying a fluid contrast agent stream with a high intensity ultrasound pulse.

公开(公告)号：US20180049731A1

公开(公告)日：2018-02-22

申请号：US15800437

申请日：2017-11-01

申请人： Muffin Incorporated

发明人： Gregory James Hardy ,  Shaun Davis Gittard ,  John C. Sigmon, JR. ,  William J. Havel ,  Jeremy T. Newkirk ,  Neal E. Fearnot ,  Rita Hadley ,  Danny A. Sherwinter ,  Vihar C. Surti ,  Tyler E. McLawhorn

IPC分类号： A61B17/00 ,  A61F2/00 ,  A61B17/04

CPC分类号： A61B17/0057 ,  A61B17/0487 ,  A61B2017/00004 ,  A61B2017/00407 ,  A61B2017/00526 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00606 ,  A61B2017/00615 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00637 ,  A61B2017/00641 ,  A61B2017/00659 ,  A61B2017/00676 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/0496 ,  A61F2/0063 ,  A61F2002/0072 ,  A61F2220/0033 ,  A61F2230/0067 ,  A61F2230/0069

摘要： There are shown and described embodiments of closure devices and systems for closing holes in tissue such as those caused unintentionally (e.g. hernia) or intentionally (e.g. openings in the right atrial appendage to access cardiac tissue). Such devices and systems include one or more mesh elements or anchors. In particular embodiments, a closure device includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for such closure devices are also described.