中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

66 records (took 0.028 seconds)

    THERMOSTABLE PHYTASE VARIANTS
    52.
    发明申请
    THERMOSTABLE PHYTASE VARIANTS 审中-公开
    热稳定的植物变种

    公开(公告)号：US20150159149A1

    公开(公告)日：2015-06-11

    申请号：US14627584

    申请日：2015-02-20

    Applicant: NOVOZYMES A/S

    Inventor： Lars Kobberoee Skov ,  Leonardo De Maria ,  Tomoko Matsui

    IPC: C12N9/96 ,  A23K1/00 ,  C12P7/14 ,  A23L1/305

    CPC classification number: C12N9/96 ,  A23K10/16 ,  A23L33/195 ,  A61K38/46 ,  C12N9/16 ,  C12N15/8243 ,  C12P7/00 ,  C12P7/14 ,  C12P21/00 ,  C12Y301/03008 ,  C12Y301/03026 ,  C12Y301/03072

    Abstract: The present invention relates to a method for producing phytase variants which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least two additional disulfide bonds as compared to this phytase. These phytase variants have modified, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensitiliby, and/or an modified glycosylation pattern. The invention also relates to the variants produced, DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.

    Abstract translation: 本发明涉及一种生产植酸酶变体的方法，所述植酸酶变体与来自柠檬酸杆菌（Citrobacter braakii）的植酸酶具有至少74％的同一性，并且与该植酸酶相比包含至少两个另外的二硫键。 这些植酸酶变体具有修饰的，优选改进的性质，例如热稳定性，温度曲线，pH曲线，比活性，动物饲料中的性能，降低的蛋白酶敏感性和/或修饰的糖基化模式。 本发明还涉及产生的变体，编码这些植酸酶的DNA，其生产方法，以及其用途，例如在动物饲料和动物饲料添加剂中。

    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    55.
    发明申请
    SERINE PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 有权

    公开(公告)号：US20220090041A1

    公开(公告)日：2022-03-24

    申请号：US17547098

    申请日：2021-12-09

    Applicant: Novozymes A/S

    Inventor： Keiichi Ayabe ,  Tomoko Matsui ,  Aki Tomiki-Hashizume ,  Yuma Kurakata ,  Esben Peter Friis ,  Jens Erik Nielsen ,  Roland Alexander Pache

    IPC: C12N9/58 ,  C12P7/06

    Abstract: The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus. The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

    Serine protease variants and polynucleotides encoding same
    58.
    发明授权
    Serine protease variants and polynucleotides encoding same 有权

    公开(公告)号：US10927361B2

    公开(公告)日：2021-02-23

    申请号：US16318496

    申请日：2017-07-14

    Applicant: NOVOZYMES A/S

    Inventor： Keiichi Ayabe ,  Tomoko Matsui ,  Aki Tomiki ,  Yuma Kurakata ,  Esben P. Friis ,  Jens E. Nielsen ,  Roland Alexander Pache

    IPC: C12N9/58 ,  C12P7/06

    Abstract: The present invention relates to protease variants, having improved properties compared to the parent protease, in particular variants of a serine protease belonging to family 53 derived from a strain of Meripilus giganteus. The variants according to the invention have in particular increased thermo-stability, e.g., increased residual activity after 30 min at a temperature in the range from 55 to 60° C. and/or increased thermal denaturation temperature, compared to the parent Meripilus giganteus protease. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Patent Agency Ranking