公开(公告)号：US20100136214A1

公开(公告)日：2010-06-03

申请号：US12697847

申请日：2010-02-01

申请人： Mukesh Kumar

发明人： Mukesh Kumar

IPC分类号： A61L27/32

CPC分类号： A61L27/306

摘要： A method for forming an acetabular shell includes providing a working surface such as a mandrel, and spraying the working surface with a first layer of material having a first composition such as aluminum oxide. After a suitable thickness is generated, the spray composition is gradually changed to other compositions having desired particle sizes and distribution. In one example, the composition is changed to a mixture of aluminum oxide and titanium oxide and/or titanium. As thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all titanium and titanium oxide. After a desired thickness is generated, the acetabular shell is extracted off the mandrel.

摘要翻译： 用于形成髋臼壳的方法包括提供诸如心轴的工作表面，以及用第一组合物如氧化铝的第一层材料喷涂工作表面。 在产生合适的厚度之后，将喷雾组合物逐渐变为具有所需粒度和分布的其它组合物。 在一个实例中，将组合物改变为氧化铝和氧化钛和/或钛的混合物。 随着厚度的增加，氧化铝的相对量降低，使得组合物全部为钛和氧化钛。 在产生期望的厚度之后，将髋臼壳从芯轴上取出。

公开(公告)号：US20100076909A1

公开(公告)日：2010-03-25

申请号：US12233637

申请日：2008-09-19

申请人： Syam S. Suri ,  Mukesh Kumar ,  Ravi S. Guduru

发明人： Syam S. Suri ,  Mukesh Kumar ,  Ravi S. Guduru

IPC分类号： G06N5/02 ,  G06F15/16

CPC分类号： H04L41/5061 ,  G06Q10/10 ,  H04L41/5074

摘要： An approach provides interactive troubleshooting. A robotic chat application receives a service inquiry over a chat session from a chat-enabled device, wherein the service inquiry is associated with a service provider network. A troubleshooting engine collects information from a user of the chat-enabled device regarding the service inquiry. The robotic chat application retrieves a flow definition and an associated query corresponding to the service inquiry based upon the collected information. The troubleshooting engine generates a command, based on the query, for resolving the service inquiry.

摘要翻译： 一种方法提供交互式故障排除。 机器人聊天应用程序通过来自启用聊天的设备的聊天会话接收服务查询，其中服务询问与服务提供商网络相关联。 故障排除引擎从具有聊天功能的设备的用户收集有关服务查询的信息。 机器人聊天应用程序基于所收集的信息检索对应于服务询问的流定义和相关联的查询。 故障排除引擎根据查询生成一个用于解析服务查询的命令。

公开(公告)号：US07595303B1

公开(公告)日：2009-09-29

申请号：US10655873

申请日：2003-09-05

申请人： Shyam S. Mohapatra ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Mukesh Kumar

IPC分类号： A61K48/00 ,  A01N63/00

CPC分类号： A61K38/217 ,  A61K38/208 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538

摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells generally modified with a nucleotide sequence encoding IL-12 and IFN-γ.

摘要翻译： 本发明涉及用于调节免疫应答的方法和药物组合物。 本发明的方法涉及向需要这种治疗的患者施用有效量的编码白细胞介素-12（IL-12），干扰素-γ（IFN-γ）或其组合的核酸分子。 本发明的药物组合物含有编码IL-12和/或IFN-γ的核酸分子和可操作地连接的启动子序列。 另一方面，本发明涉及含有编码IL-12和IFN-γ的核苷酸序列和可操作地连接的启动子序列的表达载体。 另一方面，本发明涉及用编码IL-12和IFN-γ的核苷酸序列遗传修饰的细胞。

公开(公告)号：US20090204367A1

公开(公告)日：2009-08-13

申请号：US12030462

申请日：2008-02-13

申请人： Jeffrey G. Hemmett ,  Mukesh Kumar ,  Wayne H. Woods, JR. ,  Cole E. Zemke

发明人： Jeffrey G. Hemmett ,  Mukesh Kumar ,  Wayne H. Woods, JR. ,  Cole E. Zemke

IPC分类号： G06F17/18

CPC分类号： G06F17/18

摘要： Methods for distributing a random variable by spatial interpolation with statistical corrections. The method includes assigning a numerical value of the random variable at each vertex of an array of equilateral triangles formed in a planar coordinate frame and defining a plurality of test points at respective spatial locations in the planar coordinate frame that are bounded by the array of equilateral triangles. A numerical value of the random variable is distributed at each of the test points by spatial interpolation from one or more of the numerical values of the random variable assigned at each vertex of the array of equilateral triangles. The method further includes adjusting the numerical value of the random variable distributed at each of the test points with a respective correction factor.

摘要翻译： 通过统计校正的空间插值分布随机变量的方法。 该方法包括在平面坐标系中形成的等边三角形阵列的每个顶点处分配随机变量的数值，并且在平面坐标系中的由等边阵列限定的相应空间位置处限定多个测试点 三角形。 随机变量的数值通过从等边三角形阵列的每个顶点处分配的随机变量的一个或多个数值中的空间插值分布在每个测试点。 该方法还包括用相应的校正因子来调整在每个测试点分布的随机变量的数值。

公开(公告)号：US20070137674A1

公开(公告)日：2007-06-21

申请号：US11604160

申请日：2006-11-25

申请人： George Shih ,  William Schwartz ,  Chendong Huang ,  Mukesh Kumar ,  Byung Kim ,  Sherry Mueller ,  Vijay Garg

发明人： George Shih ,  William Schwartz ,  Chendong Huang ,  Mukesh Kumar ,  Byung Kim ,  Sherry Mueller ,  Vijay Garg

IPC分类号： B08B9/00

CPC分类号： H01M8/04029 ,  H01M8/04044

摘要： A flush and fill process is used to ready a fuel cell cooling circuit for initial use. An external flushing system relasably connected to the cooling circuit circulates flushing coolant through the cooling circuit to remove contaminants from the wetted surfaces of the cooling circuit before the fuel cell is put into use. The flushing system includes a pump for circulating the flushing coolant through the cooling circuit, filters for removing contaminants from the coolant and a heater for elevating the temperature of the coolant. Following the flushing process to remove contaminants, the flushing system is disconnected from the cooling circuit and the cooling circuit is filled with fresh coolant.

摘要翻译： 使用冲洗和填充过程来准备燃料电池冷却回路以便初始使用。 可靠地连接到冷却回路的外部冲洗系统使冲洗冷却剂循环通过冷却回路，以在燃料电池投入使用之前从冷却回路的润湿表面去除污染物。 冲洗系统包括用于使冲洗冷却剂循环通过冷却回路的泵，用于从冷却剂中除去污染物的过滤器和用于升高冷却剂温度的加热器。 在冲洗过程中除去污染物后，冲洗系统与冷却回路断开，冷却回路充满新鲜的冷却液。

公开(公告)号：US20050274676A1

公开(公告)日：2005-12-15

申请号：US10865137

申请日：2004-06-10

申请人： Mukesh Kumar ,  George Shih ,  Stephen Fan

发明人： Mukesh Kumar ,  George Shih ,  Stephen Fan

IPC分类号： B01J47/04 ,  B01J47/14 ,  C02F1/42 ,  H01M8/04 ,  H01M8/10

CPC分类号： H01M8/04044 ,  B01J47/04 ,  B01J47/14 ,  B60K2001/005 ,  H01M2008/1095

摘要： A novel deionization filter for removing ions from a coolant in an electric fuel cell vehicle cooling system is disclosed. The deionization filter includes a filter housing having a coolant inlet port, through which the coolant enters the filter housing; and a coolant outlet port, through which the coolant exits the filter housing. An ion exchange bed having positively-charged and negatively-charged ion exchange resin beads is provided in the filter housing for removing negative and positive ions, respectively, from the coolant. At least one filter assembly is typically provided in the filter housing for filtering particles from the coolant.

摘要翻译： 公开了一种用于从电燃料电池车辆冷却系统中的冷却剂中去除离子的新型去离子过滤器。 去离子过滤器包括具有冷却剂入口的过滤器壳体，冷却剂通过该过滤器壳体进入过滤器壳体; 和冷却剂出口，冷却剂通过该出口端口离开过滤器壳体。 具有带正电荷和带负电荷的离子交换树脂珠粒的离子交换床分别设置在过滤器壳体中以分别从冷却剂中除去负离子和正离子。 至少一个过滤器组件通常设置在过滤器壳体中用于从冷却剂中过滤颗粒。

公开(公告)号：US06900299B1

公开(公告)日：2005-05-31

申请号：US10440000

申请日：2003-05-16

申请人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

IPC分类号： A61K39/42 ,  A61K48/00 ,  C07H21/02 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1138 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/32

摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.

摘要翻译： 提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。 还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。 通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。 还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。 提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。 提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。 还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

公开(公告)号：US06896095B2

公开(公告)日：2005-05-24

申请号：US10063151

申请日：2002-03-26

申请人： Hemant S. Shah ,  John Stuart Hollingshead ,  John Wang ,  Prakash Tuljaram Thawani ,  Richard Charles Kosik ,  Mukesh Kumar

发明人： Hemant S. Shah ,  John Stuart Hollingshead ,  John Wang ,  Prakash Tuljaram Thawani ,  Richard Charles Kosik ,  Mukesh Kumar

IPC分类号： F01P5/06 ,  F04D29/58 ,  F04D29/66 ,  F15D1/02 ,  A47B81/06

CPC分类号： F01P5/06 ,  F04D29/665 ,  F15D1/02

摘要： The present invention is a system and method to significantly reduce noise associated with air-moving devices such as an axial flow fan using a fan shroud and barrel combination with built in silencers such as Helmholtz resonators. The invention can be applied to a variety of applications such as a thermal management system for a fuel cell powered vehicle. The resonator can be a hollow cavity in networks attached to an outer or inner barrel or shroud and tuned to reduce noise at predetermined noise frequency ranges within the airflow. The invention can also attach stator members on the inner surface of the outer barrel to further reduce noise. Additional sound absorbing material, such as steel wool, can be disposed within the resonator cavity.

摘要翻译： 本发明是一种系统和方法，该系统和方法使用具有诸如亥姆霍兹共振器的内置消音器的风扇罩和桶组合来显着降低与诸如轴流风扇等空气移动装置相关联的噪声。 本发明可以应用于各种应用，例如燃料电池动力车辆的热管理系统。 谐振器可以是连接到外筒或护罩上的网络中的空腔，并且被调谐以在气流中以预定的噪声频率范围减小噪声。 本发明还可以将定子构件附接在外筒的内表面上以进一步降低噪音。 附加的吸音材料，例如钢丝绒，可以设置在谐振腔内。

公开(公告)号：US20050103033A1

公开(公告)日：2005-05-19

申请号：US10685197

申请日：2003-10-14

申请人： William Schwartz ,  Mukesh Kumar ,  Gene Cox

发明人： William Schwartz ,  Mukesh Kumar ,  Gene Cox

IPC分类号： F04B49/20 ,  F04D15/00 ,  F25B49/00 ,  F25D17/02 ,  F25B1/00 ,  G05D15/00 ,  G05D16/00 ,  G05D23/00

CPC分类号： F04D15/0066 ,  F04B49/20 ,  F04B2205/05 ,  F04B2205/06 ,  F25B49/00 ,  F25D17/02

摘要： A novel pump pressure limiting method for preventing coolant in a cooling system from reaching pressures that exceed predetermined system coolant pressure limits. The method includes reducing the system coolant pressure, as needed to prevent system over-pressurization, by reducing the operational speed of a coolant pump used to pump the coolant through the system. In one embodiment, the system coolant pressure is determined directly, by measurement of the pressure of the coolant in the system typically using pressure sensors. The operational speed of the coolant pump is then reduced until the system coolant pressure decreases to within the predetermined pressure limits. In another embodiment, the system pressure is determined indirectly, by obtaining pressure-indicating data such as coolant temperature. The coolant system pressure is then correlated with the coolant temperature or other data and then the operational speed of the coolant pump is reduced accordingly.

摘要翻译： 一种用于防止冷却系统中的冷却剂达到超过预定系统冷却剂压力极限的压力的新型泵压力限制方法。 该方法包括通过降低用于泵送冷却剂通过系统的冷却剂泵的操作速度，根据需要降低系统冷却剂压力以防止系统过压。 在一个实施例中，通过使用压力传感器测量系统中的冷却剂的压力来直接确定系统冷却剂压力。 然后冷却剂泵的操作速度降低，直到系统冷却剂压力降低到预定压力极限内。 在另一个实施例中，通过获得诸如冷却剂温度的压力指示数据来间接确定系统压力。 然后将冷却剂系统压力与冷却剂温度或其他数据相关联，然后相应地减小冷却剂泵的操作速度。

公开(公告)号：US06606729B2

公开(公告)日：2003-08-12

申请号：US09682613

申请日：2001-09-27

申请人： Blaine J. Gross ,  Mukesh Kumar

发明人： Blaine J. Gross ,  Mukesh Kumar

IPC分类号： G06F1750

CPC分类号： G06F17/5036

摘要： A method and system for creating a worst case scenario model for a given integrated circuit. The method comprises the steps of sorting skew parameters of each device into groups; and assigning a positive or negative value for each one of the groups to represent the effect of the corresponding skew parameters on the functionality of the integrated circuit. The preferred embodiment of the invention provides some of the benefits of both conventional corner simulation and Monte Carlo simulation. This approach can be implemented with only a few additional simulation iterations, which mitigates the disadvantage of Monte Carlo simulations requiring many simulation iterations. Also, this approach allows a greater degree of flexibility with respect to determining a specific corner file definition, allowing the designer to explore a greater area of model parameter space to insure that the circuit will meet performance requirements over extremes of process technology variation.