公开(公告)号：US20090280143A1

公开(公告)日：2009-11-12

申请号：US12476896

申请日：2009-06-02

申请人： Shyam S. Mohapatra ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Mukesh Kumar

IPC分类号： A61K39/385 ,  A61K39/00 ,  A61K35/00 ,  C12N5/00 ,  C12N15/63 ,  A61K31/7052 ,  A61P37/04

CPC分类号： A61K38/217 ,  A61K38/208 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538

摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ.

摘要翻译： 本发明涉及用于调节免疫应答的方法和药物组合物。 本发明的方法涉及向需要这种治疗的患者施用有效量的编码白细胞介素-12（IL-12），干扰素-γ（IFN-γ）或其组合的核酸分子。 本发明的药物组合物含有编码IL-12和/或IFN-γ的核酸分子和可操作地连接的启动子序列。 另一方面，本发明涉及含有编码IL-12和IFN-γ的核苷酸序列和可操作地连接的启动子序列的表达载体。 另一方面，本发明涉及用编码IL-12和IFN-γ的核苷酸序列遗传修饰的细胞。

公开(公告)号：US20110052601A1

公开(公告)日：2011-03-03

申请号：US12390246

申请日：2009-02-20

申请人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

IPC分类号： A61K39/42 ,  A61P11/00 ,  A61P31/12

CPC分类号： C12N15/1138 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/32

摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.

摘要翻译： 提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。 还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。 通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。 还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。 提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。 提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。 还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

公开(公告)号：US06489306B2

公开(公告)日：2002-12-03

申请号：US09259411

申请日：1999-02-23

申请人： Shyam S. Mohapatra ,  Hiroto Matsuse ,  Aruna K. Behera ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Hiroto Matsuse ,  Aruna K. Behera ,  Mukesh Kumar

IPC分类号： A61K4800

CPC分类号： A61K38/217 ,  A61K48/00 ,  Y10S977/924

摘要： A method of preventing a respiratory infection by administering DNA which encodes IFN is provided. Also provided is a therapy for the prevention of a respiratory infection containing DNA which encodes IFN.

摘要翻译： 提供了通过施用编码IFN的DNA来预防呼吸道感染的方法。 还提供了用于预防含有编码IFN的DNA的呼吸道感染的治疗方法。

公开(公告)号：US07595303B1

公开(公告)日：2009-09-29

申请号：US10655873

申请日：2003-09-05

申请人： Shyam S. Mohapatra ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Mukesh Kumar

IPC分类号： A61K48/00 ,  A01N63/00

CPC分类号： A61K38/217 ,  A61K38/208 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538

摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells generally modified with a nucleotide sequence encoding IL-12 and IFN-γ.

摘要翻译： 本发明涉及用于调节免疫应答的方法和药物组合物。 本发明的方法涉及向需要这种治疗的患者施用有效量的编码白细胞介素-12（IL-12），干扰素-γ（IFN-γ）或其组合的核酸分子。 本发明的药物组合物含有编码IL-12和/或IFN-γ的核酸分子和可操作地连接的启动子序列。 另一方面，本发明涉及含有编码IL-12和IFN-γ的核苷酸序列和可操作地连接的启动子序列的表达载体。 另一方面，本发明涉及用编码IL-12和IFN-γ的核苷酸序列遗传修饰的细胞。

公开(公告)号：US06900299B1

公开(公告)日：2005-05-31

申请号：US10440000

申请日：2003-05-16

申请人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Aruna Behera ,  Hiroto Matsuse ,  Mukesh Kumar

IPC分类号： A61K39/42 ,  A61K48/00 ,  C07H21/02 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1138 ,  C12N15/111 ,  C12N2310/11 ,  C12N2320/32

摘要： There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV infection by administering an effective amount of an agent that interferes with the binding of RSV to ICAM-1. A method of preventing RSV infection by administering an effective amount of an agent that down regulates the expression of ICAM-1, thereby decreasing RSV binding to ICAM-1 is also provided. There is provided a method of treating RSV infection by administering an effective amount of an agent for down regulating ICAM-1 expression. A method of blocking RSV-ICAM-1 interaction by administering an effective amount of agents for blocking ICAM sites of binding is provided. Also provided is a compound for blocking RSV-ICAM-1 interaction including an agent for blocking ICAM sites of binding.

摘要翻译： 提供了一种通过施用有效量的用于调节ICAM-1表达的试剂来预防呼吸道感染的方法。 还提供了用于预防呼吸道感染的组合物，包括调节ICAM表达的药剂。 通过施用有效量的妨碍RSV与ICAM-1的结合的试剂来预防RSV感染的方法。 还提供了通过施用有效量的下调ICAM-1的表达的试剂，从而降低RSV与ICAM-1的结合来预防RSV感染的方法。 提供了通过施用有效量的用于下调ICAM-1表达的试剂来治疗RSV感染的方法。 提供了通过施用有效量的阻断ICAM结合位点的试剂阻断RSV-ICAM-1相互作用的方法。 还提供了用于阻断RSV-ICAM-1相互作用的化合物，其包括用于阻断结合的ICAM位点的试剂。

公开(公告)号：US08603458B2

公开(公告)日：2013-12-10

申请号：US12476896

申请日：2009-06-02

申请人： Shyam S. Mohapatra ,  Mukesh Kumar

发明人： Shyam S. Mohapatra ,  Mukesh Kumar

IPC分类号： A61K48/00 ,  A61K39/385

CPC分类号： A61K38/217 ,  A61K38/208 ,  A61K39/35 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/55538

摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells genetically modified with a nucleotide sequence encoding IL-12 and IFN-γ.

公开(公告)号：US07118888B2

公开(公告)日：2006-10-10

申请号：US10073065

申请日：2002-02-12

申请人： Shyam S. Mohapatra ,  Mukesh Kumar ,  Shua-ku Huang ,  Kam Leong

发明人： Shyam S. Mohapatra ,  Mukesh Kumar ,  Shua-ku Huang ,  Kam Leong

IPC分类号： C12P21/06

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/53 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/55583 ,  C12N2760/18522 ,  C12N2760/18534

摘要： An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA antibodies, cytotoxic T lymphocytes, and IFN-γ production in the lung and splenocytes. A single dose of GXV induces a drastic reduction of viral titers.

公开(公告)号：US09102215B2

公开(公告)日：2015-08-11

申请号：US13274729

申请日：2011-10-17

申请人： Mukesh Kumar ,  Paul B. Hoke ,  Martha E. Nefcy ,  David Wong

发明人： Mukesh Kumar ,  Paul B. Hoke ,  Martha E. Nefcy ,  David Wong

IPC分类号： B60H1/00 ,  F28F27/00 ,  F24F11/00

CPC分类号： B60H1/00842 ,  B60H1/00021 ,  B60H1/00735 ,  B60H1/00742 ,  B60H2001/002 ,  F24F11/30 ,  F24F2110/00 ,  F24F2110/10 ,  F24F2120/10

摘要： A comfort system is provided for a motor vehicle. A seat occupancy sensor determines whether a third row zone is occupied. At least one flow controller is provided in the floor duct for controllably supplying the conditioned airflow to at least the third row outlet. If the third row zone is occupied, then a second row outlet and the third row outlet are turned on to supply a conditioned airflow to a front seat zone, a second row zone, and the third row zone. If the third row zone is not occupied, then the third row outlet is closed off. If the second row zone is not occupied, then the second and third row outlets are closed off. If occupied, then the second row outlet is turned on until a desired comfort level is achieved in the second row zone.

摘要翻译： 为汽车提供舒适系统。 座椅占用传感器确定第三行区域是否被占用。 至少一个流量控制器设置在地板管道中，用于可控地将经调节的气流提供给至少第三排出口。 如果第三排区域被占用，则第二排出口和第三排出口被打开以向前排座位区域，第二排区域和第三行区域提供经调节的气流。 如果第三排区域未被占用，则第三行出口被关闭。 如果第二行区域未被占用，则第二和第三行出口被关闭。 如果被占用，则第二排出口被打开，直到在第二行区域中达到期望的舒适度。

公开(公告)号：US08641134B2

公开(公告)日：2014-02-04

申请号：US13437423

申请日：2012-04-02

申请人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

发明人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

IPC分类号： B60H1/24

CPC分类号： B60H1/00564 ,  B60H1/245 ,  B60H1/246

摘要： An air duct for an automotive vehicle is blow molded with an elongated, hollow structural member to be used as a portion of a body of the vehicle. The structural member has an inner wall defining an elongated cavity communicating with first and second access holes at respective longitudinal positions along the structural member. A parison comprised of a thermally insulating material is inserted into the internal cavity. A source of inflation gas is connected to a mouth portion or the parison. The parison is heated and inflated within the internal cavity to an expanded shape to form the air duct disposed against the inner wall and spanning the first and second access holes. The air duct at one of the access holes is configured as an air inlet. The air duct at the other one of the access holes is configured as an air outlet.

摘要翻译： 用于机动车辆的空气管道是吹塑成型的，具有细长的中空结构件，用作车身的一部分。 结构构件具有限定在沿着结构构件的各个纵向位置处与第一和第二进入孔连通的细长腔的内壁。 将由隔热材料构成的型坯插入内部空腔。 膨胀气体源连接到口部或型坯。 型坯在内腔内被加热膨胀成扩张形状，以形成靠在内壁上并横跨第一和第二进入孔的空气通道。 一个进入孔的空气管道被构造为空气入口。 在另一个进入孔的空气管道被配置为空气出口。

公开(公告)号：US20130257106A1

公开(公告)日：2013-10-03

申请号：US13437423

申请日：2012-04-02

申请人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

发明人： Robert S. Sawyer ,  Mukesh Kumar ,  Martha E. Nefcy

IPC分类号： B60H1/26 ,  B29C49/22

CPC分类号： B60H1/00564 ,  B60H1/245 ,  B60H1/246

摘要： An air duct for an automotive vehicle is blow molded with an elongated, hollow structural member to be used as a portion of a body of the vehicle. The structural member has an inner wall defining an elongated cavity communicating with first and second access holes at respective longitudinal positions along the structural member. A parison comprised of a thermally insulating material is inserted into the internal cavity. A source of inflation gas is connected to a mouth portion or the parison. The parison is heated and inflated within the internal cavity to an expanded shape to form the air duct disposed against the inner wall and spanning the first and second access holes. The air duct at one of the access holes is configured as an air inlet. The air duct at the other one of the access holes is configured as an air outlet.

摘要翻译： 用于机动车辆的空气管道是吹塑成型的，具有细长的中空结构件，用作车身的一部分。 结构构件具有限定在沿着结构构件的各个纵向位置处与第一和第二进入孔连通的细长腔的内壁。 将由隔热材料构成的型坯插入内部空腔。 膨胀气体源连接到口部或型坯。 型坯在内腔内被加热膨胀成扩张形状，以形成靠在内壁上并横跨第一和第二进入孔的空气通道。 一个进入孔的空气管道被构造为空气入口。 在另一个进入孔的空气管道被配置为空气出口。