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    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON
    53.
    发明申请
    HYDROGEL CONTACT LENSES WITH LUBRICIOUS COATING THEREON 审中-公开

    公开(公告)号：US20200001555A1

    公开(公告)日：2020-01-02

    申请号：US16565977

    申请日：2019-09-10

    Applicant: Novartis AG

    Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Jared Nelson

    IPC: B29D11/00 ,  C08F20/00 ,  G02B1/04

    Abstract: The invention is generally related to soft contact lenses which comprise a non-silicone hydrogel lens body and a hydrogel coating thereon. The non-silicone hydrogel lens body is composed of a hydrogel material which is free of silicone and comprises at least 50% by mole of repeating units of at least one hydroxyl-containing vinylic monomer. The hydrogel coating comprises a first polymeric material having first reactive functional groups and a hydrogel layer derived from a second polymeric material having second reactive functional groups, and the hydrogel layer is covalently attached onto the anchor layer through linkages each formed between one first reactive functional group and one second reactive functional group. The soft contact lens has a surface lubricity better than the lubricity of the non-silicone hydrogel lens body and has a friction rating of about 2 or lower after 7 cycles of manual rubbing, a water content of from about 10% to about 85% by weight and an elastic modulus of from about 0.2 MPa to about 1.5 MPa when being fully hydrated at room temperature.

    PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS
    57.
    发明申请
    PHOSPHORYLCHOLINE-CONTAINING POLY(METH)ACRYLAMIDE-BASED COPOLYMERS 审中-公开

    公开(公告)号：US20190023891A1

    公开(公告)日：2019-01-24

    申请号：US16036983

    申请日：2018-07-17

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

    IPC: C08L33/26 ,  C08K5/523

    Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymer comprising dangling (i.e., pendant) phosphorylcholine groups and dangling (i.e., pendant) reactive groups or chains each of which comprises one carboxyl group, one thiol group, or one primary or secondary amino group. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

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