公开(公告)号：US20050010042A1

公开(公告)日：2005-01-13

申请号：US10919272

申请日：2004-08-17

申请人： Steven Ruben ,  Charles Birse ,  Roxanne Duan ,  Daniel Soppet ,  Craig Rosen ,  Yanggu Shi ,  David LaFleur ,  Henrik Olsen ,  Reinhard Ebner ,  Kimberly Florence ,  Jian Ni ,  Paul Young

发明人： Steven Ruben ,  Charles Birse ,  Roxanne Duan ,  Daniel Soppet ,  Craig Rosen ,  Yanggu Shi ,  David LaFleur ,  Henrik Olsen ,  Reinhard Ebner ,  Kimberly Florence ,  Jian Ni ,  Paul Young

IPC分类号： G01N33/50 ,  A61K31/711 ,  A61K38/00 ,  A61P1/04 ,  A61P7/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  G01N33/15 ,  G01N33/53 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US20070238664A1

公开(公告)日：2007-10-11

申请号：US11751886

申请日：2007-05-22

申请人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

发明人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

IPC分类号： C07K14/47 ,  A61K38/00 ,  C07H21/04 ,  C12N15/63 ,  G01N33/53 ,  G01N33/48 ,  C07K16/00 ,  C07K1/00

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20070172830A1

公开(公告)日：2007-07-26

申请号：US10849979

申请日：2004-05-21

申请人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

发明人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

IPC分类号： C12Q1/68 ,  A61K48/00 ,  A61K38/17 ,  C07K14/47 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070154910A1

公开(公告)日：2007-07-05

申请号：US11565909

申请日：2006-12-01

申请人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

发明人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050215775A1

公开(公告)日：2005-09-29

申请号：US10979111

申请日：2004-11-02

申请人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

发明人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N9/00 ,  C12P21/06 ,  C12Q1/68

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：US20050208622A1

公开(公告)日：2005-09-22

申请号：US10970493

申请日：2004-10-22

申请人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

发明人： Paul Moore ,  Steven Ruben ,  David LaFleur ,  Yanggu Shi ,  Craig Rosen ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090068201A1

公开(公告)日：2009-03-12

申请号：US12170333

申请日：2008-07-09

申请人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K39/395 ,  A61K38/00 ,  C12N5/06 ,  A61P31/00

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US06403770B1

公开(公告)日：2002-06-11

申请号：US09589287

申请日：2000-06-08

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： C07K1600

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

公开(公告)号：US20090169565A1

公开(公告)日：2009-07-02

申请号：US12393693

申请日：2009-02-26

申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53 ,  A61P37/00

CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.

摘要翻译： 本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。 本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。 还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。

公开(公告)号：US20100196360A9

公开(公告)日：2010-08-05

申请号：US12210134

申请日：2008-09-12

申请人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen ,  Stephen Ullrich

发明人： GUO-LIANG YU ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen ,  Stephen Ullrich

IPC分类号： A61K39/395 ,  C12Q1/00 ,  A61P35/00 ,  A61K39/00 ,  G01N33/536 ,  A61K31/519

CPC分类号： G01N33/56972 ,  A61K31/519 ,  A61K38/00 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/70575 ,  C07K14/715 ,  C07K16/24 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N2333/52 ,  G01N2800/24

摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。