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114 条记录 (耗时 0.048 秒)

    Tissue separating device with reinforced support for anchoring mechanisms
    52.
    发明授权
    Tissue separating device with reinforced support for anchoring mechanisms 有权
    组织分离装置，具有用于锚固机构的加强支撑

    公开(公告)号：US09592324B2

    公开(公告)日：2017-03-14

    申请号：US11980155

    申请日：2007-10-30

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61L31/14 ,  A61L31/08

    CPC分类号： A61L31/14 ,  A61F2/0063 ,  A61L31/08

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Barrier layer with underlying medical device and one or more reinforcing support structures
    53.
    发明授权
    Barrier layer with underlying medical device and one or more reinforcing support structures 有权
    具有底层医疗装置和一个或多个加强支撑结构的阻隔层

    公开(公告)号：US09492596B2

    公开(公告)日：2016-11-15

    申请号：US11701799

    申请日：2007-02-02

    申请人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    发明人： Steve A. Herweck ,  Joseph Ferraro ,  Paul Martakos ,  Theodore Karwoski ,  Anthony Richard Horton

    IPC分类号： A61F2/02 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/145 ,  A61F2/0063 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/606

    摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with anchoring reinforcements to aid with the fastening of the barrier device for implantation purposes and reinforcing truss sections or portions that prohibit or substantially reduce the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.

    摘要翻译： 阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。 如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。 底层结构可以是手术网的形式。 隔离装置还设置有锚固加强件，以帮助阻挡装置的固定用于植入目的，并且加强桁架部分或部分，其禁止或基本上减少过度拉伸和撕裂的发生。 阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

    Expandable fluoropolymer device for delivery of therapeutic agents and method of making
    56.
    发明授权
    Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
    用于递送治疗剂的可扩展含氟聚合物装置和制备方法

    公开(公告)号：US07740793B2

    公开(公告)日：2010-06-22

    申请号：US11068680

    申请日：2005-02-28

    申请人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/041 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1075 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  C08L27/18

    摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.

    摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。