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151 条记录 (耗时 0.072 秒)

    Human Tumor Necrosis Factor TR20 and Methods Based Thereon
    52.
    发明申请
    Human Tumor Necrosis Factor TR20 and Methods Based Thereon 审中-公开
    人类肿瘤坏死因子TR20及其方法

    公开(公告)号：US20070160595A1

    公开(公告)日：2007-07-12

    申请号：US11610981

    申请日：2006-12-14

    申请人： Steven Ruben ,  Kevin Baker ,  Jian Ni

    发明人： Steven Ruben ,  Kevin Baker ,  Jian Ni

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/42

    CPC分类号： C07K14/525 ,  C07K14/70575

    摘要： The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.

    摘要翻译： 本发明涉及TR20多肽。 特别地，提供编码人TR20蛋白的分离的核酸分子。 还提供TR20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR20活性的激动剂和拮抗剂的筛选方法。

    Antibodies to Chemokine Alpha-5
    53.
    发明申请
    Antibodies to Chemokine Alpha-5 失效
    趋化因子α-5抗体

    公开(公告)号：US20060008882A1

    公开(公告)日：2006-01-12

    申请号：US11224076

    申请日：2005-09-13

    申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52 ,  C07K16/24

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

    摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。 特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。 还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。 本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    19 human secreted proteins
    56.
    发明申请
    19 human secreted proteins 审中-公开
    19种人体分泌的蛋白质

    公开(公告)号：US20060188962A1

    公开(公告)日：2006-08-24

    申请号：US11404843

    申请日：2006-04-17

    申请人： Kenneth Carter ,  Ping Feng ,  Craig Rosen ,  Steven Ruben ,  Gregory Endress

    发明人： Kenneth Carter ,  Ping Feng ,  Craig Rosen ,  Steven Ruben ,  Gregory Endress

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Follistatin-3
    58.
    发明申请
    Follistatin-3 有权

    公开(公告)号：US20070275895A1

    公开(公告)日：2007-11-29

    申请号：US11738846

    申请日：2007-04-23

    申请人： D. Duan ,  Steven Ruben

    发明人： D. Duan ,  Steven Ruben

    IPC分类号： C07K14/435 ,  A61K38/17 ,  A61P15/00 ,  A61P19/00 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10 ,  C07K16/18 ,  A61P35/00 ,  C07H21/04

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021 ,  C12N2799/026

    摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

    摘要翻译： 本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。 特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。 还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。

    Human secreted proteins
    59.
    发明申请
    Human secreted proteins 审中-公开
    人体分泌的蛋白质

    公开(公告)号：US20070048818A1

    公开(公告)日：2007-03-01

    申请号：US10868184

    申请日：2004-06-16

    申请人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

    发明人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

    IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/47

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Human Oncogene Induced Secreted Protein I
    60.
    发明申请
    Human Oncogene Induced Secreted Protein I 审中-公开
    人类癌基因诱导的分泌蛋白I

    公开(公告)号：US20070020277A1

    公开(公告)日：2007-01-25

    申请号：US11532050

    申请日：2006-09-14

    申请人： Henrik Olsen ,  Steven Ruben

    发明人： Henrik Olsen ,  Steven Ruben

    IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Antibodies to human HOIPS I are also provided, as are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.

    摘要翻译： 本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。 特别地，提供编码人HOIPS I蛋白的分离的核酸分子。 还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。 还提供了人HOIPS I的抗体，以及用于检测异常细胞增殖和分化障碍的诊断方法以及用于治疗它们的治疗方法。